Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146998514> ?p ?o ?g. }
- W2146998514 endingPage "547" @default.
- W2146998514 startingPage "541" @default.
- W2146998514 abstract "Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox−) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4-aldoxime had the best profile: its kox− approached that of the therapeutic oxime P2S (310 vs. 120 l mol−1 min−1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pKa nearer to 8 and enhance their therapeutic potential." @default.
- W2146998514 created "2016-06-24" @default.
- W2146998514 creator A5017330006 @default.
- W2146998514 creator A5053748891 @default.
- W2146998514 creator A5057500075 @default.
- W2146998514 creator A5071643756 @default.
- W2146998514 date "2011-08-01" @default.
- W2146998514 modified "2023-09-30" @default.
- W2146998514 title "Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning" @default.
- W2146998514 cites W1965224657 @default.
- W2146998514 cites W1972416887 @default.
- W2146998514 cites W1975576469 @default.
- W2146998514 cites W1976826333 @default.
- W2146998514 cites W1982936710 @default.
- W2146998514 cites W1987635501 @default.
- W2146998514 cites W1993932020 @default.
- W2146998514 cites W1999952613 @default.
- W2146998514 cites W2001170121 @default.
- W2146998514 cites W2005995682 @default.
- W2146998514 cites W2007680471 @default.
- W2146998514 cites W2012071801 @default.
- W2146998514 cites W2017900878 @default.
- W2146998514 cites W2024784182 @default.
- W2146998514 cites W2033386176 @default.
- W2146998514 cites W2035203682 @default.
- W2146998514 cites W2048581466 @default.
- W2146998514 cites W2058919195 @default.
- W2146998514 cites W2073313942 @default.
- W2146998514 cites W2078321575 @default.
- W2146998514 cites W2080594218 @default.
- W2146998514 cites W2088040365 @default.
- W2146998514 cites W2110551149 @default.
- W2146998514 cites W2115475052 @default.
- W2146998514 cites W2141459230 @default.
- W2146998514 cites W2319571623 @default.
- W2146998514 cites W2320999760 @default.
- W2146998514 cites W2322799826 @default.
- W2146998514 cites W2322994589 @default.
- W2146998514 cites W2325291848 @default.
- W2146998514 cites W4240508851 @default.
- W2146998514 doi "https://doi.org/10.1016/j.jfluchem.2011.05.028" @default.
- W2146998514 hasPublicationYear "2011" @default.
- W2146998514 type Work @default.
- W2146998514 sameAs 2146998514 @default.
- W2146998514 citedByCount "21" @default.
- W2146998514 countsByYear W21469985142012 @default.
- W2146998514 countsByYear W21469985142014 @default.
- W2146998514 countsByYear W21469985142015 @default.
- W2146998514 countsByYear W21469985142016 @default.
- W2146998514 countsByYear W21469985142017 @default.
- W2146998514 countsByYear W21469985142018 @default.
- W2146998514 countsByYear W21469985142019 @default.
- W2146998514 countsByYear W21469985142020 @default.
- W2146998514 countsByYear W21469985142023 @default.
- W2146998514 crossrefType "journal-article" @default.
- W2146998514 hasAuthorship W2146998514A5017330006 @default.
- W2146998514 hasAuthorship W2146998514A5053748891 @default.
- W2146998514 hasAuthorship W2146998514A5057500075 @default.
- W2146998514 hasAuthorship W2146998514A5071643756 @default.
- W2146998514 hasConcept C102931765 @default.
- W2146998514 hasConcept C150903083 @default.
- W2146998514 hasConcept C155647269 @default.
- W2146998514 hasConcept C161790260 @default.
- W2146998514 hasConcept C164361826 @default.
- W2146998514 hasConcept C170493617 @default.
- W2146998514 hasConcept C178790620 @default.
- W2146998514 hasConcept C181199279 @default.
- W2146998514 hasConcept C185592680 @default.
- W2146998514 hasConcept C207001950 @default.
- W2146998514 hasConcept C21951064 @default.
- W2146998514 hasConcept C2778706303 @default.
- W2146998514 hasConcept C2778816929 @default.
- W2146998514 hasConcept C2779485729 @default.
- W2146998514 hasConcept C2779648554 @default.
- W2146998514 hasConcept C2780292010 @default.
- W2146998514 hasConcept C55493867 @default.
- W2146998514 hasConcept C74998103 @default.
- W2146998514 hasConcept C86803240 @default.
- W2146998514 hasConceptScore W2146998514C102931765 @default.
- W2146998514 hasConceptScore W2146998514C150903083 @default.
- W2146998514 hasConceptScore W2146998514C155647269 @default.
- W2146998514 hasConceptScore W2146998514C161790260 @default.
- W2146998514 hasConceptScore W2146998514C164361826 @default.
- W2146998514 hasConceptScore W2146998514C170493617 @default.
- W2146998514 hasConceptScore W2146998514C178790620 @default.
- W2146998514 hasConceptScore W2146998514C181199279 @default.
- W2146998514 hasConceptScore W2146998514C185592680 @default.
- W2146998514 hasConceptScore W2146998514C207001950 @default.
- W2146998514 hasConceptScore W2146998514C21951064 @default.
- W2146998514 hasConceptScore W2146998514C2778706303 @default.
- W2146998514 hasConceptScore W2146998514C2778816929 @default.
- W2146998514 hasConceptScore W2146998514C2779485729 @default.
- W2146998514 hasConceptScore W2146998514C2779648554 @default.
- W2146998514 hasConceptScore W2146998514C2780292010 @default.
- W2146998514 hasConceptScore W2146998514C55493867 @default.
- W2146998514 hasConceptScore W2146998514C74998103 @default.
- W2146998514 hasConceptScore W2146998514C86803240 @default.
- W2146998514 hasIssue "8" @default.