Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147005440> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2147005440 abstract "Repeated administration of ochratoxin A (OTA) caused renal morphological dose-related changes, that were associated with proximal tubular and glomerular damage the latter showing oedema and prominent PAS staining suggestive of glomerular basement membrane thickening. On the other hand, the combined administration of repeated doses of OTA and aflatoxin B[1] (2. 5 mg and 100 ug per kg, respectively), appeared to have a synergistic effect, characterized by severe disruption of proximal tubules and general morphological derrangement of the glomerulus, involving intense and faint staining nuclei (suggestive of cell necrosis) and cytoplasmic vacuolation, which was not seen with either toxin alone. When clinical biochemical parameters were measured after repeated administration of a low dose of OTA, enzymuria, glucosuria, polyuria and proteinuria were observed, with glucose and alkaline phosphatase as the most sensitive parameters. Metabolic studies performed in vitro showed that isolated pig and rat glomeruli incorporate different amino acids linearly for several hours at different rates and perform oxidative metabolism of glucose and fatty acids to CO[2] also linearly. For pig glomeruli the order of amino acid incorporation was LEU >> PRO = HIS > LYS > GLY and for rat glomeruli it was TRP >> PHE > TYR = LEU > PRO > HIS. The same amino acids were incorporated in a similar way in rat tubules, but the incorporation rate is 10-fold lower. When de novo synthesis of protein by pig glomeruli exposed to different chemicals was assessed, using proline (PRO) as the precursor, adriamycin (ADR) and ethacrynic acid (ETA) inhibited protein synthesis more than 2-bromoethanamine (BEA) and streptomycin (STR), and much more than puromycin aminonucleoside (PAN). When isolated rat glomeruli were exposed to low concentrations of OTA, there was a generalized inhibition on de novo synthesis of protein from the six amino acids tested and the aromatic amino acids (TRP, TYR and PHE) were more sensitive to OTA effect than PRO. Low concentrations of OTA (10 - 100 uM) enhanced glomerular and tubular glucose metabolism to CO[2] and only high concentrations of the mycotoxin (1000 uM) caused significant inhibition of glomerular and proximal tubular linolenic acid metabolism." @default.
- W2147005440 created "2016-06-24" @default.
- W2147005440 creator A5032967420 @default.
- W2147005440 date "1988-01-01" @default.
- W2147005440 modified "2023-09-28" @default.
- W2147005440 title "The effect of natural toxicants and other chemicals on the kidney." @default.
- W2147005440 hasPublicationYear "1988" @default.
- W2147005440 type Work @default.
- W2147005440 sameAs 2147005440 @default.
- W2147005440 citedByCount "0" @default.
- W2147005440 crossrefType "dissertation" @default.
- W2147005440 hasAuthorship W2147005440A5032967420 @default.
- W2147005440 hasConcept C126189478 @default.
- W2147005440 hasConcept C126322002 @default.
- W2147005440 hasConcept C134018914 @default.
- W2147005440 hasConcept C185592680 @default.
- W2147005440 hasConcept C2778305430 @default.
- W2147005440 hasConcept C2780091579 @default.
- W2147005440 hasConcept C515207424 @default.
- W2147005440 hasConcept C54355233 @default.
- W2147005440 hasConcept C55493867 @default.
- W2147005440 hasConcept C71924100 @default.
- W2147005440 hasConcept C74864618 @default.
- W2147005440 hasConcept C86803240 @default.
- W2147005440 hasConceptScore W2147005440C126189478 @default.
- W2147005440 hasConceptScore W2147005440C126322002 @default.
- W2147005440 hasConceptScore W2147005440C134018914 @default.
- W2147005440 hasConceptScore W2147005440C185592680 @default.
- W2147005440 hasConceptScore W2147005440C2778305430 @default.
- W2147005440 hasConceptScore W2147005440C2780091579 @default.
- W2147005440 hasConceptScore W2147005440C515207424 @default.
- W2147005440 hasConceptScore W2147005440C54355233 @default.
- W2147005440 hasConceptScore W2147005440C55493867 @default.
- W2147005440 hasConceptScore W2147005440C71924100 @default.
- W2147005440 hasConceptScore W2147005440C74864618 @default.
- W2147005440 hasConceptScore W2147005440C86803240 @default.
- W2147005440 hasLocation W21470054401 @default.
- W2147005440 hasOpenAccess W2147005440 @default.
- W2147005440 hasPrimaryLocation W21470054401 @default.
- W2147005440 hasRelatedWork W1587720892 @default.
- W2147005440 hasRelatedWork W159918262 @default.
- W2147005440 hasRelatedWork W1917703807 @default.
- W2147005440 hasRelatedWork W1975260998 @default.
- W2147005440 hasRelatedWork W1975556353 @default.
- W2147005440 hasRelatedWork W2019399338 @default.
- W2147005440 hasRelatedWork W2037359977 @default.
- W2147005440 hasRelatedWork W2047910216 @default.
- W2147005440 hasRelatedWork W2052306287 @default.
- W2147005440 hasRelatedWork W2065234099 @default.
- W2147005440 hasRelatedWork W2085925936 @default.
- W2147005440 hasRelatedWork W2092048595 @default.
- W2147005440 hasRelatedWork W2134230348 @default.
- W2147005440 hasRelatedWork W2198875004 @default.
- W2147005440 hasRelatedWork W2405847436 @default.
- W2147005440 hasRelatedWork W2442855101 @default.
- W2147005440 hasRelatedWork W294025396 @default.
- W2147005440 hasRelatedWork W3137204 @default.
- W2147005440 hasRelatedWork W99332757 @default.
- W2147005440 hasRelatedWork W2125851573 @default.
- W2147005440 isParatext "false" @default.
- W2147005440 isRetracted "false" @default.
- W2147005440 magId "2147005440" @default.
- W2147005440 workType "dissertation" @default.