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- W2147005542 abstract "Objective) Discrimination between hypogonadotropic hypogonadism (HH) and constitutional delayed puberty (DP) is difficult in prepubertal patients. We retrospectively analyzed the usefulness of the gonadotropin-re- leasing hormone (GnRH) test using time-resolved fluoroimmunoassay (TR-FIA) for the measurement of gonadotro- pins and the human chorionic gonadotropin (hCG) test to discriminate between HH and DP during the prepubertal period. (Method) Gonadal function was evaluated by the hCG test and the GnRH test using TR-FIA in 16 prepubertal boys who were suspected of having HH, of whom after long-term observation 11 boys were finally diagnosed with HH and 5 boys with DP. (Results) In the GnRH test, peak LH levels were below the normal range in all HH patients and within the normal range in 4 of the 5 DP patients. Peak FSH levels were within the normal range in 4 of the 5 DP patients and below the normal range in 9 of the 11 HH patients. In the hCG test, testosterone levels after 3-day administration of hCG were below 50ng/ml in all HH patients except one 6-month-old infant and above 50ng/dl in all DP patients. (Conclusion) GnRH testing using the TR-FIA assay is useful for diagnosis of HH during the prepubertal period. The combination of GnRH and hCG tests might improve diagnostic accuracy." @default.
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- W2147005542 date "2003-01-01" @default.
- W2147005542 modified "2023-09-28" @default.
- W2147005542 title "The Usefulness of GnRH and hCG Testing for the DifferentiaI Diagnosis of Delayed Puberty and Hypogonadotropic Hypogonadism in Prepubertal Boys" @default.
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