FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147006435> ?p ?o ?g. }

• W2147006435 endingPage "7989" @default.
• W2147006435 startingPage "7982" @default.
• W2147006435 abstract "Strains of Escherichia coli which lack detectable guanosine 3',5'-bispyrophosphate (ppGpp) display a pleiotropic phenotype that in some respects resembles that of rpoS (katF) mutants. This led us to examine whether ppGpp is a positive regulator of sigma s synthesis. sigma s is a stationary-phase-specific sigma factor that is encoded by the rpoS gene. We found that a ppGpp-deficient strain is defective in sigma s synthesis as cells enter stationary phase in a rich medium, as judged by immunoblots. Under more-defined conditions we found that the stimulation of sigma s synthesis following glucose, phosphate, or amino acid starvation of wild-type strains is greatly reduced in a strain lacking ppGpp. The failure of ppGpp-deficient strains to synthesize sigma s in response to these starvation regimens could indicate a general defect in gene expression rather than a specific dependence of rpoS expression on ppGpp. We therefore tested the effect of artificially elevated ppGpp levels on sigma s synthesis either with mutations that impair ppGpp decay or by gratuitously inducing ppGpp synthesis with a Ptac::relA fusion. In both instances, we observed enhanced sigma s synthesis. Apparently, ppGpp can activate sigma s synthesis under conditions of nutrient sufficiency as well as during entry into stationary phase. This finding suggests that changes in ppGpp levels function both as a signal of imminent stationary phase and as a signal of perturbations in steady-state growth." @default.
• W2147006435 created "2016-06-24" @default.
• W2147006435 creator A5004114738 @default.
• W2147006435 creator A5029069211 @default.
• W2147006435 creator A5056878568 @default.
• W2147006435 creator A5070194026 @default.
• W2147006435 creator A5075824492 @default.
• W2147006435 date "1993-12-01" @default.
• W2147006435 modified "2023-10-10" @default.
• W2147006435 title "Synthesis of the stationary-phase sigma factor sigma s is positively regulated by ppGpp" @default.
• W2147006435 cites W1488674567 @default.
• W2147006435 cites W1492266534 @default.
• W2147006435 cites W1519243375 @default.
• W2147006435 cites W1554039407 @default.
• W2147006435 cites W1556986896 @default.
• W2147006435 cites W1572960817 @default.
• W2147006435 cites W1583996118 @default.
• W2147006435 cites W1587638614 @default.
• W2147006435 cites W1595587942 @default.
• W2147006435 cites W1616230851 @default.
• W2147006435 cites W1619808619 @default.
• W2147006435 cites W1781531090 @default.
• W2147006435 cites W1827965966 @default.
• W2147006435 cites W1890358491 @default.
• W2147006435 cites W1898197987 @default.
• W2147006435 cites W1922471182 @default.
• W2147006435 cites W1966062750 @default.
• W2147006435 cites W1995109131 @default.
• W2147006435 cites W2010175731 @default.
• W2147006435 cites W2011552096 @default.
• W2147006435 cites W2018289835 @default.
• W2147006435 cites W2035849178 @default.
• W2147006435 cites W2044236499 @default.
• W2147006435 cites W2065472522 @default.
• W2147006435 cites W2072580044 @default.
• W2147006435 cites W2072802762 @default.
• W2147006435 cites W2087175715 @default.
• W2147006435 cites W2089386865 @default.
• W2147006435 cites W2092668948 @default.
• W2147006435 cites W2101108802 @default.
• W2147006435 cites W2123582115 @default.
• W2147006435 cites W2124786260 @default.
• W2147006435 cites W2141767930 @default.
• W2147006435 cites W2161737754 @default.
• W2147006435 cites W2302327121 @default.
• W2147006435 cites W290865292 @default.
• W2147006435 doi "https://doi.org/10.1128/jb.175.24.7982-7989.1993" @default.
• W2147006435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/206978" @default.
• W2147006435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8253685" @default.
• W2147006435 hasPublicationYear "1993" @default.
• W2147006435 type Work @default.
• W2147006435 sameAs 2147006435 @default.
• W2147006435 citedByCount "431" @default.
• W2147006435 countsByYear W21470064352012 @default.
• W2147006435 countsByYear W21470064352013 @default.
• W2147006435 countsByYear W21470064352014 @default.
• W2147006435 countsByYear W21470064352015 @default.
• W2147006435 countsByYear W21470064352016 @default.
• W2147006435 countsByYear W21470064352017 @default.
• W2147006435 countsByYear W21470064352018 @default.
• W2147006435 countsByYear W21470064352019 @default.
• W2147006435 countsByYear W21470064352020 @default.
• W2147006435 countsByYear W21470064352021 @default.
• W2147006435 countsByYear W21470064352022 @default.
• W2147006435 countsByYear W21470064352023 @default.
• W2147006435 crossrefType "journal-article" @default.
• W2147006435 hasAuthorship W2147006435A5004114738 @default.
• W2147006435 hasAuthorship W2147006435A5029069211 @default.
• W2147006435 hasAuthorship W2147006435A5056878568 @default.
• W2147006435 hasAuthorship W2147006435A5070194026 @default.
• W2147006435 hasAuthorship W2147006435A5075824492 @default.
• W2147006435 hasBestOaLocation W21470064351 @default.
• W2147006435 hasConcept C101762097 @default.
• W2147006435 hasConcept C104317684 @default.
• W2147006435 hasConcept C121332964 @default.
• W2147006435 hasConcept C143065580 @default.
• W2147006435 hasConcept C150194340 @default.
• W2147006435 hasConcept C26628138 @default.
• W2147006435 hasConcept C2776449523 @default.
• W2147006435 hasConcept C2777712861 @default.
• W2147006435 hasConcept C2777995097 @default.
• W2147006435 hasConcept C2778049214 @default.
• W2147006435 hasConcept C47319516 @default.
• W2147006435 hasConcept C547475151 @default.
• W2147006435 hasConcept C55493867 @default.
• W2147006435 hasConcept C62520636 @default.
• W2147006435 hasConcept C86803240 @default.
• W2147006435 hasConceptScore W2147006435C101762097 @default.
• W2147006435 hasConceptScore W2147006435C104317684 @default.
• W2147006435 hasConceptScore W2147006435C121332964 @default.
• W2147006435 hasConceptScore W2147006435C143065580 @default.
• W2147006435 hasConceptScore W2147006435C150194340 @default.
• W2147006435 hasConceptScore W2147006435C26628138 @default.
• W2147006435 hasConceptScore W2147006435C2776449523 @default.
• W2147006435 hasConceptScore W2147006435C2777712861 @default.
• W2147006435 hasConceptScore W2147006435C2777995097 @default.
• W2147006435 hasConceptScore W2147006435C2778049214 @default.
• W2147006435 hasConceptScore W2147006435C47319516 @default.

• next