Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147014710> ?p ?o ?g. }
- W2147014710 endingPage "580" @default.
- W2147014710 startingPage "563" @default.
- W2147014710 abstract "Cardiovascular diseases are still the most important cause of morbidity and mortality in western countries and antithrombotic treatment is nowadays widely used. Drugs able to reduce coagulation activation are the treatment of choice for a number of arterial and/or venous thromboembolic conditions. Some of the drugs currently used for this purpose, such as heparins (UFH or LMWH) and VKA, have limitations consisting of a narrow therapeutic window and an unpredictable response with the need of laboratory monitoring in order to assess their efficacy and safety. These drawbacks have stimulated an active research aimed to develop new drugs able to act on single factors involved in the coagulation network, with predictable response. Intense experimental and clinical work on new drugs has focused on synthetic agents, which could preferably be administered orally and at fixed doses. The most advanced clinical development with new anticoagulants has been achieved for those inhibiting FXa and some of them, like fondaparinux, are already currently used in clinical practice. Other agents, such as rivaroxaban, apixaban, otamixaban and edoxaban are under development and have already been studied or are currently under investigation in large scale phase III clinical trials for prevention and treatment of venous thromboembolism, atrial fibrillation and acute coronary syndromes. Some of them have proved to be more effective than conventional therapy. Data on some agents inhibiting FVa are still preliminary and some of these drugs have so far been considered only in patients with disseminated intravascular coagulation secondary to sepsis." @default.
- W2147014710 created "2016-06-24" @default.
- W2147014710 creator A5037378269 @default.
- W2147014710 creator A5038753812 @default.
- W2147014710 date "2011-09-09" @default.
- W2147014710 modified "2023-09-25" @default.
- W2147014710 title "Inhibitors of propagation of coagulation: factors V and X" @default.
- W2147014710 cites W104010772 @default.
- W2147014710 cites W1509564652 @default.
- W2147014710 cites W1564690174 @default.
- W2147014710 cites W1566182873 @default.
- W2147014710 cites W1574970897 @default.
- W2147014710 cites W1964688878 @default.
- W2147014710 cites W1972117348 @default.
- W2147014710 cites W1972235071 @default.
- W2147014710 cites W1973233314 @default.
- W2147014710 cites W1975247464 @default.
- W2147014710 cites W1976815461 @default.
- W2147014710 cites W1978092152 @default.
- W2147014710 cites W1979304423 @default.
- W2147014710 cites W1983727955 @default.
- W2147014710 cites W1983829357 @default.
- W2147014710 cites W1985842169 @default.
- W2147014710 cites W1986131884 @default.
- W2147014710 cites W1991799973 @default.
- W2147014710 cites W1992794479 @default.
- W2147014710 cites W2000025003 @default.
- W2147014710 cites W2000389681 @default.
- W2147014710 cites W2002723489 @default.
- W2147014710 cites W2003726612 @default.
- W2147014710 cites W2004111625 @default.
- W2147014710 cites W2008587961 @default.
- W2147014710 cites W2008790685 @default.
- W2147014710 cites W2012355067 @default.
- W2147014710 cites W2014396085 @default.
- W2147014710 cites W2014491911 @default.
- W2147014710 cites W2022932023 @default.
- W2147014710 cites W2028762958 @default.
- W2147014710 cites W2029833181 @default.
- W2147014710 cites W2034197529 @default.
- W2147014710 cites W2036506340 @default.
- W2147014710 cites W2041726150 @default.
- W2147014710 cites W2045987573 @default.
- W2147014710 cites W2047935802 @default.
- W2147014710 cites W2057065644 @default.
- W2147014710 cites W2064627639 @default.
- W2147014710 cites W2066676409 @default.
- W2147014710 cites W2066736865 @default.
- W2147014710 cites W2067118403 @default.
- W2147014710 cites W2068476516 @default.
- W2147014710 cites W2071869524 @default.
- W2147014710 cites W2075196907 @default.
- W2147014710 cites W2075304792 @default.
- W2147014710 cites W2075359369 @default.
- W2147014710 cites W2079974368 @default.
- W2147014710 cites W2085021241 @default.
- W2147014710 cites W2088494721 @default.
- W2147014710 cites W2090413727 @default.
- W2147014710 cites W2095901832 @default.
- W2147014710 cites W2098108939 @default.
- W2147014710 cites W2099467398 @default.
- W2147014710 cites W2100365169 @default.
- W2147014710 cites W2103247642 @default.
- W2147014710 cites W2112564023 @default.
- W2147014710 cites W2114189419 @default.
- W2147014710 cites W2115501014 @default.
- W2147014710 cites W2115513773 @default.
- W2147014710 cites W2115787552 @default.
- W2147014710 cites W2123448465 @default.
- W2147014710 cites W2127090290 @default.
- W2147014710 cites W2133326664 @default.
- W2147014710 cites W2133686162 @default.
- W2147014710 cites W2134908914 @default.
- W2147014710 cites W2137801654 @default.
- W2147014710 cites W2143281433 @default.
- W2147014710 cites W2144508450 @default.
- W2147014710 cites W2149388786 @default.
- W2147014710 cites W2150567120 @default.
- W2147014710 cites W2151252098 @default.
- W2147014710 cites W2159553511 @default.
- W2147014710 cites W2169843156 @default.
- W2147014710 cites W2170189969 @default.
- W2147014710 cites W2170493914 @default.
- W2147014710 cites W2189476799 @default.
- W2147014710 cites W2322121630 @default.
- W2147014710 cites W2328631833 @default.
- W2147014710 cites W2335822722 @default.
- W2147014710 cites W2403689317 @default.
- W2147014710 cites W2554875937 @default.
- W2147014710 cites W2558305316 @default.
- W2147014710 cites W2559274756 @default.
- W2147014710 cites W2559957202 @default.
- W2147014710 cites W2586385595 @default.
- W2147014710 cites W2979592470 @default.
- W2147014710 cites W4205312708 @default.
- W2147014710 cites W4211188108 @default.
- W2147014710 cites W4236825038 @default.
- W2147014710 cites W4245765453 @default.