Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147020187> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2147020187 endingPage "8" @default.
- W2147020187 startingPage "272" @default.
- W2147020187 abstract "The potential structural similarity of technetium-99m-labeled glucaric acid (99mTc-glucarate) to that of fructose suggests that this agent may enter cells by a sugar transport system. Studies with LLC-PK1 cells demonstrated inhibition of 99mTc-glucarate uptake by fructose, confirming this potential relationship. Since anaerobic metabolism can use either glucose or fructose, we hypothesized that 99mTc-glucarate may concentrate in areas of acute ischemic injury. To test this hypothesis, 63 adult rats with middle cerebral artery (MCA) occlusion followed by reperfusion were injected with 99mTc-glucarate and in vivo and ex vivo images were acquired. Seven animals were also studied with 18FDG and high resolution PET imaging. The radionuclide images were compared to the results of triphenyl tetrazolium chloride (TTC) staining and conventional histopathology. Thirty-five rats had significant accumulation of 99mTc-glucarate and no TTC staining (indicating infarction) in the involved hemisphere. Of the remaining 28 rats with TTC staining (suggesting viability) of the involved hemisphere, 16 (57%) had 99mTc-glucarate accumulation. In the seven rats that were studied with both 99mTc-glucarate and 18FDG, 99mTc-glucarate accumulated at the center of the occluded MCA territory while 18FDG activity was decreased in this region. These results suggest that 99mTc-glucarate is a sensitive marker of acute severe cerebral injury, but its mechanism of localization is probably different from that of 18FDG." @default.
- W2147020187 created "2016-06-24" @default.
- W2147020187 creator A5011811008 @default.
- W2147020187 creator A5011940844 @default.
- W2147020187 creator A5016040891 @default.
- W2147020187 creator A5025214577 @default.
- W2147020187 creator A5032498512 @default.
- W2147020187 creator A5046668695 @default.
- W2147020187 creator A5053443174 @default.
- W2147020187 creator A5053450104 @default.
- W2147020187 date "1991-02-01" @default.
- W2147020187 modified "2023-09-26" @default.
- W2147020187 title "Localization of technetium-99m-glucarate in zones of acute cerebral injury." @default.
- W2147020187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1704054" @default.
- W2147020187 hasPublicationYear "1991" @default.
- W2147020187 type Work @default.
- W2147020187 sameAs 2147020187 @default.
- W2147020187 citedByCount "15" @default.
- W2147020187 countsByYear W21470201872012 @default.
- W2147020187 countsByYear W21470201872015 @default.
- W2147020187 countsByYear W21470201872018 @default.
- W2147020187 countsByYear W21470201872019 @default.
- W2147020187 crossrefType "journal-article" @default.
- W2147020187 hasAuthorship W2147020187A5011811008 @default.
- W2147020187 hasAuthorship W2147020187A5011940844 @default.
- W2147020187 hasAuthorship W2147020187A5016040891 @default.
- W2147020187 hasAuthorship W2147020187A5025214577 @default.
- W2147020187 hasAuthorship W2147020187A5032498512 @default.
- W2147020187 hasAuthorship W2147020187A5046668695 @default.
- W2147020187 hasAuthorship W2147020187A5053443174 @default.
- W2147020187 hasAuthorship W2147020187A5053450104 @default.
- W2147020187 hasConcept C126322002 @default.
- W2147020187 hasConcept C142724271 @default.
- W2147020187 hasConcept C150903083 @default.
- W2147020187 hasConcept C185592680 @default.
- W2147020187 hasConcept C202751555 @default.
- W2147020187 hasConcept C207001950 @default.
- W2147020187 hasConcept C26291073 @default.
- W2147020187 hasConcept C2776390042 @default.
- W2147020187 hasConcept C2989005 @default.
- W2147020187 hasConcept C522557706 @default.
- W2147020187 hasConcept C541997718 @default.
- W2147020187 hasConcept C544855455 @default.
- W2147020187 hasConcept C55493867 @default.
- W2147020187 hasConcept C71924100 @default.
- W2147020187 hasConcept C74864618 @default.
- W2147020187 hasConcept C86803240 @default.
- W2147020187 hasConceptScore W2147020187C126322002 @default.
- W2147020187 hasConceptScore W2147020187C142724271 @default.
- W2147020187 hasConceptScore W2147020187C150903083 @default.
- W2147020187 hasConceptScore W2147020187C185592680 @default.
- W2147020187 hasConceptScore W2147020187C202751555 @default.
- W2147020187 hasConceptScore W2147020187C207001950 @default.
- W2147020187 hasConceptScore W2147020187C26291073 @default.
- W2147020187 hasConceptScore W2147020187C2776390042 @default.
- W2147020187 hasConceptScore W2147020187C2989005 @default.
- W2147020187 hasConceptScore W2147020187C522557706 @default.
- W2147020187 hasConceptScore W2147020187C541997718 @default.
- W2147020187 hasConceptScore W2147020187C544855455 @default.
- W2147020187 hasConceptScore W2147020187C55493867 @default.
- W2147020187 hasConceptScore W2147020187C71924100 @default.
- W2147020187 hasConceptScore W2147020187C74864618 @default.
- W2147020187 hasConceptScore W2147020187C86803240 @default.
- W2147020187 hasIssue "2" @default.
- W2147020187 hasLocation W21470201871 @default.
- W2147020187 hasOpenAccess W2147020187 @default.
- W2147020187 hasPrimaryLocation W21470201871 @default.
- W2147020187 hasRelatedWork W1972952460 @default.
- W2147020187 hasRelatedWork W2006464131 @default.
- W2147020187 hasRelatedWork W2057572195 @default.
- W2147020187 hasRelatedWork W2071323736 @default.
- W2147020187 hasRelatedWork W2073464570 @default.
- W2147020187 hasRelatedWork W2189581189 @default.
- W2147020187 hasRelatedWork W2356912377 @default.
- W2147020187 hasRelatedWork W2506800161 @default.
- W2147020187 hasRelatedWork W2589933419 @default.
- W2147020187 hasRelatedWork W2793947261 @default.
- W2147020187 hasVolume "32" @default.
- W2147020187 isParatext "false" @default.
- W2147020187 isRetracted "false" @default.
- W2147020187 magId "2147020187" @default.
- W2147020187 workType "article" @default.