FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147028982> ?p ?o ?g. }

• W2147028982 endingPage "G914" @default.
• W2147028982 startingPage "G909" @default.
• W2147028982 abstract "The present study assesses the effects of the phosphodiesterase inhibitor IBMX on norepinephrine (NE)-induced constriction of small mesenteric arteries. Arteries (∼150 μm) were dissected from rats and mounted on a wire myograph for isometric force measurement. NE concentration effect curves were generated after exposure to 500 μM IBMX for 60 min. IBMX significantly reduced NE-induced tension development. Studies were also conducted following sarcoplasmic reticulum (SR) depletion (ryanodine, 10 μM) or L-type Ca 2+ channel blockade [(+)-BAY K 8644, 10 μM] in the presence and absence of IBMX. Both SR depletion and L-channel blockade reduced NE-induced tension generation, consistent with incomplete Ca 2+ mobilization. IBMX significantly attenuated NE responses in ryanodine and (+)-BAY K 8644-treated vessels. Finally, treatment of NE-stimulated vessels with IBMX (500 μM) caused a reduction in vascular tension that was greater than the concomitant reduction in cytosolic Ca 2+ concentration ([Ca 2+ ] i ), indicating that a portion of the IBMX-mediated relaxation is Ca 2+ -independent. These data suggest that IBMX attenuation of NE responsiveness not only involves a reduction in [Ca 2+ ] i but also a significant decrease in Ca 2+ sensitivity." @default.
• W2147028982 created "2016-06-24" @default.
• W2147028982 creator A5032704557 @default.
• W2147028982 creator A5054700319 @default.
• W2147028982 creator A5063293908 @default.
• W2147028982 creator A5073021091 @default.
• W2147028982 date "1999-04-01" @default.
• W2147028982 modified "2023-10-18" @default.
• W2147028982 title "Effects of IBMX on norepinephrine-induced vasoconstriction in small mesenteric arteries" @default.
• W2147028982 cites W1492308129 @default.
• W2147028982 cites W1509564023 @default.
• W2147028982 cites W1558224598 @default.
• W2147028982 cites W1753089048 @default.
• W2147028982 cites W1874327812 @default.
• W2147028982 cites W1970445852 @default.
• W2147028982 cites W1981889097 @default.
• W2147028982 cites W1986338378 @default.
• W2147028982 cites W1990176374 @default.
• W2147028982 cites W2009263467 @default.
• W2147028982 cites W2018961290 @default.
• W2147028982 cites W2028368672 @default.
• W2147028982 cites W2036246796 @default.
• W2147028982 cites W2037404641 @default.
• W2147028982 cites W2043782147 @default.
• W2147028982 cites W2045547130 @default.
• W2147028982 cites W2061014404 @default.
• W2147028982 cites W2068287788 @default.
• W2147028982 cites W2081321976 @default.
• W2147028982 cites W2089742414 @default.
• W2147028982 cites W2090260029 @default.
• W2147028982 cites W2112881946 @default.
• W2147028982 cites W2124453548 @default.
• W2147028982 cites W2148499749 @default.
• W2147028982 cites W2172944768 @default.
• W2147028982 cites W2176647628 @default.
• W2147028982 cites W2342078210 @default.
• W2147028982 cites W2485048152 @default.
• W2147028982 cites W261751860 @default.
• W2147028982 cites W43633648 @default.
• W2147028982 cites W95567247 @default.
• W2147028982 doi "https://doi.org/10.1152/ajpgi.1999.276.4.g909" @default.
• W2147028982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10198334" @default.
• W2147028982 hasPublicationYear "1999" @default.
• W2147028982 type Work @default.
• W2147028982 sameAs 2147028982 @default.
• W2147028982 citedByCount "8" @default.
• W2147028982 countsByYear W21470289822017 @default.
• W2147028982 countsByYear W21470289822018 @default.
• W2147028982 countsByYear W21470289822023 @default.
• W2147028982 crossrefType "journal-article" @default.
• W2147028982 hasAuthorship W2147028982A5032704557 @default.
• W2147028982 hasAuthorship W2147028982A5054700319 @default.
• W2147028982 hasAuthorship W2147028982A5063293908 @default.
• W2147028982 hasAuthorship W2147028982A5073021091 @default.
• W2147028982 hasConcept C103486182 @default.
• W2147028982 hasConcept C120770815 @default.
• W2147028982 hasConcept C126322002 @default.
• W2147028982 hasConcept C134018914 @default.
• W2147028982 hasConcept C185592680 @default.
• W2147028982 hasConcept C24998067 @default.
• W2147028982 hasConcept C2776820930 @default.
• W2147028982 hasConcept C2779276759 @default.
• W2147028982 hasConcept C2779941686 @default.
• W2147028982 hasConcept C2779961880 @default.
• W2147028982 hasConcept C2780771799 @default.
• W2147028982 hasConcept C2781298581 @default.
• W2147028982 hasConcept C71924100 @default.
• W2147028982 hasConceptScore W2147028982C103486182 @default.
• W2147028982 hasConceptScore W2147028982C120770815 @default.
• W2147028982 hasConceptScore W2147028982C126322002 @default.
• W2147028982 hasConceptScore W2147028982C134018914 @default.
• W2147028982 hasConceptScore W2147028982C185592680 @default.
• W2147028982 hasConceptScore W2147028982C24998067 @default.
• W2147028982 hasConceptScore W2147028982C2776820930 @default.
• W2147028982 hasConceptScore W2147028982C2779276759 @default.
• W2147028982 hasConceptScore W2147028982C2779941686 @default.
• W2147028982 hasConceptScore W2147028982C2779961880 @default.
• W2147028982 hasConceptScore W2147028982C2780771799 @default.
• W2147028982 hasConceptScore W2147028982C2781298581 @default.
• W2147028982 hasConceptScore W2147028982C71924100 @default.
• W2147028982 hasIssue "4" @default.
• W2147028982 hasLocation W21470289821 @default.
• W2147028982 hasLocation W21470289822 @default.
• W2147028982 hasOpenAccess W2147028982 @default.
• W2147028982 hasPrimaryLocation W21470289821 @default.
• W2147028982 hasRelatedWork W1966140016 @default.
• W2147028982 hasRelatedWork W2042694887 @default.
• W2147028982 hasRelatedWork W2051904051 @default.
• W2147028982 hasRelatedWork W2149630312 @default.
• W2147028982 hasRelatedWork W2290222886 @default.
• W2147028982 hasRelatedWork W2332248880 @default.
• W2147028982 hasRelatedWork W2743090782 @default.
• W2147028982 hasRelatedWork W3006114350 @default.
• W2147028982 hasRelatedWork W3129120246 @default.
• W2147028982 hasRelatedWork W1832823702 @default.
• W2147028982 hasVolume "276" @default.
• W2147028982 isParatext "false" @default.
• W2147028982 isRetracted "false" @default.

• next