FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147042014> ?p ?o ?g. }

• W2147042014 endingPage "584" @default.
• W2147042014 startingPage "577" @default.
• W2147042014 abstract "We have examined whether the two cysteine residues (Cys30 and Cys34) in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor are palmitoylated via thioesters and whether these residues influence the biologic function of the receptor. To do this, mouse L cells expressing wild-type and mutant receptors were analyzed by metabolic labeling with [3H]palmitate, immunoprecipitation, and SDS-PAGE. Both Cys30 and Cys34 were found to be sites of palmitoylation and together they accounted for the total palmitoylation of the receptor. The palmitate rapidly turned over with a half-life of approximately 2 h compared to a half-life of greater than 40 h for the protein. Mutation of Cys34 to Ala resulted in the gradual accumulation of the receptor in dense lysosomes and the total loss of cathepsin D sorting function in the Golgi. A Cys30 to Ala mutation had no biologic consequences, showing the importance of Cys34. Mutation of amino acids 35-39 to alanines impaired palmitoylation of Cys30 and Cys34 and resulted in abnormal receptor trafficking to lysosomes and loss of cathepsin D sorting. These data suggest that palmitoylation of Cys30 and Cys34 leads to anchoring of this region of the cytoplasmic tail to the lipid bilayer. Anchoring via Cys34 is essential for the normal trafficking and lysosomal enzyme sorting function of the receptor." @default.
• W2147042014 created "2016-06-24" @default.
• W2147042014 creator A5007864342 @default.
• W2147042014 creator A5009038540 @default.
• W2147042014 creator A5039396802 @default.
• W2147042014 date "1996-02-15" @default.
• W2147042014 modified "2023-10-16" @default.
• W2147042014 title "Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting." @default.
• W2147042014 cites W1481094350 @default.
• W2147042014 cites W1482239855 @default.
• W2147042014 cites W1517742055 @default.
• W2147042014 cites W1520282358 @default.
• W2147042014 cites W1525290983 @default.
• W2147042014 cites W1552158310 @default.
• W2147042014 cites W1554226168 @default.
• W2147042014 cites W1565504291 @default.
• W2147042014 cites W1566171899 @default.
• W2147042014 cites W1572595133 @default.
• W2147042014 cites W1587023798 @default.
• W2147042014 cites W1607595902 @default.
• W2147042014 cites W1609531590 @default.
• W2147042014 cites W1623804763 @default.
• W2147042014 cites W1925289812 @default.
• W2147042014 cites W1940796694 @default.
• W2147042014 cites W1979757599 @default.
• W2147042014 cites W1983926699 @default.
• W2147042014 cites W1987778328 @default.
• W2147042014 cites W1996103689 @default.
• W2147042014 cites W1999130956 @default.
• W2147042014 cites W2006006113 @default.
• W2147042014 cites W2018289835 @default.
• W2147042014 cites W2019714218 @default.
• W2147042014 cites W2025661319 @default.
• W2147042014 cites W2028051170 @default.
• W2147042014 cites W2031541160 @default.
• W2147042014 cites W2055920490 @default.
• W2147042014 cites W2060913542 @default.
• W2147042014 cites W2072800830 @default.
• W2147042014 cites W2083176073 @default.
• W2147042014 cites W2095017414 @default.
• W2147042014 cites W2101108802 @default.
• W2147042014 cites W2112439460 @default.
• W2147042014 cites W2128949141 @default.
• W2147042014 cites W2133362776 @default.
• W2147042014 cites W2135702611 @default.
• W2147042014 cites W2140596567 @default.
• W2147042014 cites W2160809286 @default.
• W2147042014 cites W2315642448 @default.
• W2147042014 cites W326103902 @default.
• W2147042014 doi "https://doi.org/10.1083/jcb.132.4.577" @default.
• W2147042014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199859" @default.
• W2147042014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8647889" @default.
• W2147042014 hasPublicationYear "1996" @default.
• W2147042014 type Work @default.
• W2147042014 sameAs 2147042014 @default.
• W2147042014 citedByCount "92" @default.
• W2147042014 countsByYear W21470420142012 @default.
• W2147042014 countsByYear W21470420142013 @default.
• W2147042014 countsByYear W21470420142014 @default.
• W2147042014 countsByYear W21470420142015 @default.
• W2147042014 countsByYear W21470420142016 @default.
• W2147042014 countsByYear W21470420142018 @default.
• W2147042014 countsByYear W21470420142019 @default.
• W2147042014 countsByYear W21470420142022 @default.
• W2147042014 crossrefType "journal-article" @default.
• W2147042014 hasAuthorship W2147042014A5007864342 @default.
• W2147042014 hasAuthorship W2147042014A5009038540 @default.
• W2147042014 hasAuthorship W2147042014A5039396802 @default.
• W2147042014 hasBestOaLocation W21470420142 @default.
• W2147042014 hasConcept C104317684 @default.
• W2147042014 hasConcept C120694314 @default.
• W2147042014 hasConcept C143065580 @default.
• W2147042014 hasConcept C146727910 @default.
• W2147042014 hasConcept C167844969 @default.
• W2147042014 hasConcept C170493617 @default.
• W2147042014 hasConcept C181199279 @default.
• W2147042014 hasConcept C190062978 @default.
• W2147042014 hasConcept C2775887612 @default.
• W2147042014 hasConcept C2775960820 @default.
• W2147042014 hasConcept C2778822930 @default.
• W2147042014 hasConcept C2779201268 @default.
• W2147042014 hasConcept C2780216420 @default.
• W2147042014 hasConcept C55493867 @default.
• W2147042014 hasConcept C86803240 @default.
• W2147042014 hasConcept C95444343 @default.
• W2147042014 hasConceptScore W2147042014C104317684 @default.
• W2147042014 hasConceptScore W2147042014C120694314 @default.
• W2147042014 hasConceptScore W2147042014C143065580 @default.
• W2147042014 hasConceptScore W2147042014C146727910 @default.
• W2147042014 hasConceptScore W2147042014C167844969 @default.
• W2147042014 hasConceptScore W2147042014C170493617 @default.
• W2147042014 hasConceptScore W2147042014C181199279 @default.
• W2147042014 hasConceptScore W2147042014C190062978 @default.
• W2147042014 hasConceptScore W2147042014C2775887612 @default.
• W2147042014 hasConceptScore W2147042014C2775960820 @default.
• W2147042014 hasConceptScore W2147042014C2778822930 @default.
• W2147042014 hasConceptScore W2147042014C2779201268 @default.
• W2147042014 hasConceptScore W2147042014C2780216420 @default.

• next