Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147043229> ?p ?o ?g. }
- W2147043229 endingPage "2294" @default.
- W2147043229 startingPage "2283" @default.
- W2147043229 abstract "Depressions of regional cerebral metabolism beyond the epileptogenic zone have been demonstrated in patients with intractable temporal lobe epilepsy. However, their clinical relevance, and the causes of prefrontal metabolic asymmetries are less well understood. We investigated 96 temporal lobe epilepsy patients by FDG-PET and neuropsychological assessment who had a corresponding unilateral temporal hypometabolism, left hemisphere speech dominance, full scale IQ of > 70 and no extratemporal lesion in MRIs. The regional glucose metabolism was determined in each patient in homologous regions including prefrontal cortex, and normalized to whole brain metabolism. Regional differences of > 10% were regarded as asymmetrical. Prefrontal metabolic asymmetries were more frequent in patients with left temporal lobe epilepsy (21 left, six right) and a history of secondarily generalized seizures. A multivariate analysis of variance revealed a main effect for prefrontal metabolic asymmetry on neuropsychological 'frontal lobe measures', including verbal and performance intelligence measures. Prefrontal metabolic asymmetry was not related to 'measures of episodic memory', presence of psychiatric symptoms or frontal interictal epileptiform discharges. We conclude that prefrontal metabolic asymmetry is associated with cognitive impairment. Patients with temporal lobe epilepsy of the left speech dominant hemisphere and a history of secondarily generalized seizures are at considerable risk of developing prefrontal metabolic asymmetry." @default.
- W2147043229 created "2016-06-24" @default.
- W2147043229 creator A5074052560 @default.
- W2147043229 date "1997-12-01" @default.
- W2147043229 modified "2023-10-15" @default.
- W2147043229 title "Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy" @default.
- W2147043229 cites W1536683769 @default.
- W2147043229 cites W1883094066 @default.
- W2147043229 cites W1964218052 @default.
- W2147043229 cites W1966161855 @default.
- W2147043229 cites W1969567982 @default.
- W2147043229 cites W1974320313 @default.
- W2147043229 cites W1975466720 @default.
- W2147043229 cites W1977695592 @default.
- W2147043229 cites W1979476832 @default.
- W2147043229 cites W1987373100 @default.
- W2147043229 cites W1988137020 @default.
- W2147043229 cites W1989087306 @default.
- W2147043229 cites W1991431676 @default.
- W2147043229 cites W2002062618 @default.
- W2147043229 cites W2006743533 @default.
- W2147043229 cites W2015919669 @default.
- W2147043229 cites W2023365414 @default.
- W2147043229 cites W2039186518 @default.
- W2147043229 cites W2050823038 @default.
- W2147043229 cites W2053267868 @default.
- W2147043229 cites W2055170091 @default.
- W2147043229 cites W2057049846 @default.
- W2147043229 cites W2065946966 @default.
- W2147043229 cites W2066483015 @default.
- W2147043229 cites W2069961421 @default.
- W2147043229 cites W2071489210 @default.
- W2147043229 cites W2072003268 @default.
- W2147043229 cites W2072762935 @default.
- W2147043229 cites W2080790127 @default.
- W2147043229 cites W2085000083 @default.
- W2147043229 cites W2090203522 @default.
- W2147043229 cites W2093083608 @default.
- W2147043229 cites W2134423692 @default.
- W2147043229 cites W2138210540 @default.
- W2147043229 cites W2140577650 @default.
- W2147043229 cites W2147596767 @default.
- W2147043229 cites W2150448030 @default.
- W2147043229 cites W2155030828 @default.
- W2147043229 cites W2157271972 @default.
- W2147043229 cites W2167134408 @default.
- W2147043229 cites W2227856689 @default.
- W2147043229 cites W224070021 @default.
- W2147043229 cites W2263035612 @default.
- W2147043229 cites W2326482977 @default.
- W2147043229 cites W2773467741 @default.
- W2147043229 cites W2951578238 @default.
- W2147043229 cites W597766098 @default.
- W2147043229 cites W2189044291 @default.
- W2147043229 cites W2401190212 @default.
- W2147043229 doi "https://doi.org/10.1093/brain/120.12.2283" @default.
- W2147043229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9448582" @default.
- W2147043229 hasPublicationYear "1997" @default.
- W2147043229 type Work @default.
- W2147043229 sameAs 2147043229 @default.
- W2147043229 citedByCount "169" @default.
- W2147043229 countsByYear W21470432292012 @default.
- W2147043229 countsByYear W21470432292013 @default.
- W2147043229 countsByYear W21470432292014 @default.
- W2147043229 countsByYear W21470432292015 @default.
- W2147043229 countsByYear W21470432292016 @default.
- W2147043229 countsByYear W21470432292017 @default.
- W2147043229 countsByYear W21470432292018 @default.
- W2147043229 countsByYear W21470432292019 @default.
- W2147043229 countsByYear W21470432292020 @default.
- W2147043229 countsByYear W21470432292021 @default.
- W2147043229 countsByYear W21470432292022 @default.
- W2147043229 countsByYear W21470432292023 @default.
- W2147043229 crossrefType "journal-article" @default.
- W2147043229 hasAuthorship W2147043229A5074052560 @default.
- W2147043229 hasBestOaLocation W21470432291 @default.
- W2147043229 hasConcept C105641010 @default.
- W2147043229 hasConcept C14216870 @default.
- W2147043229 hasConcept C15744967 @default.
- W2147043229 hasConcept C169760540 @default.
- W2147043229 hasConcept C169900460 @default.
- W2147043229 hasConcept C17755696 @default.
- W2147043229 hasConcept C2778186239 @default.
- W2147043229 hasConcept C2781099131 @default.
- W2147043229 hasConcept C2781195155 @default.
- W2147043229 hasConcept C548259974 @default.
- W2147043229 hasConcept C71924100 @default.
- W2147043229 hasConceptScore W2147043229C105641010 @default.
- W2147043229 hasConceptScore W2147043229C14216870 @default.
- W2147043229 hasConceptScore W2147043229C15744967 @default.
- W2147043229 hasConceptScore W2147043229C169760540 @default.
- W2147043229 hasConceptScore W2147043229C169900460 @default.
- W2147043229 hasConceptScore W2147043229C17755696 @default.
- W2147043229 hasConceptScore W2147043229C2778186239 @default.
- W2147043229 hasConceptScore W2147043229C2781099131 @default.
- W2147043229 hasConceptScore W2147043229C2781195155 @default.
- W2147043229 hasConceptScore W2147043229C548259974 @default.
- W2147043229 hasConceptScore W2147043229C71924100 @default.