Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147047346> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2147047346 endingPage "4232" @default.
- W2147047346 startingPage "4196" @default.
- W2147047346 abstract "Curcumin (1) is a secondary metabolite of turmeric, derived from Curcuma longa L. and was shown to have many biological activities. One of the most interesting properties of curcumin (1) is the antitumour activity allied with the ability to act as a multidrug resistance (MDR) modulator. Several curcumin derivatives have been synthesized with the purpose of discovering more information about the mechanisms of action, to establish structure-activity relationships (SAR), and to overcome pharmacokinetic problems. Over the past few decades, more potent and more stable curcumin derivatives have emerged with potential as drug candidates. Some important SAR studies pointed out that the unstable α,β-unsaturated diketone linker present in curcumin (1) may not be necessary for the antitumour activity; generally, shorter linkers result in more potent compounds than curcumin (1); the type of substituents and their substitution pattern are crucial regarding the biological activities of interest. Overall, the structure of curcumin (1) may represent an important basis for the development of more effective therapeutic agents, particularly in chemotherapy, as reflected by ongoing clinical trials. This article aims to review the synthesis and biological activities of curcumin (1) and derivatives, highlighting the MDR modulation properties of curcumin (1), since these effects makes this natural product a promising lead compound for the development of new anticancer drugs." @default.
- W2147047346 created "2016-06-24" @default.
- W2147047346 creator A5045651626 @default.
- W2147047346 creator A5060586851 @default.
- W2147047346 creator A5072794458 @default.
- W2147047346 creator A5086489095 @default.
- W2147047346 date "2015-12-04" @default.
- W2147047346 modified "2023-09-24" @default.
- W2147047346 title "Curcumin: A Natural Lead for Potential New Drug Candidates" @default.
- W2147047346 doi "https://doi.org/10.2174/0929867322666151029104611" @default.
- W2147047346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26511469" @default.
- W2147047346 hasPublicationYear "2015" @default.
- W2147047346 type Work @default.
- W2147047346 sameAs 2147047346 @default.
- W2147047346 citedByCount "62" @default.
- W2147047346 countsByYear W21470473462016 @default.
- W2147047346 countsByYear W21470473462017 @default.
- W2147047346 countsByYear W21470473462018 @default.
- W2147047346 countsByYear W21470473462019 @default.
- W2147047346 countsByYear W21470473462020 @default.
- W2147047346 countsByYear W21470473462021 @default.
- W2147047346 countsByYear W21470473462022 @default.
- W2147047346 countsByYear W21470473462023 @default.
- W2147047346 crossrefType "journal-article" @default.
- W2147047346 hasAuthorship W2147047346A5045651626 @default.
- W2147047346 hasAuthorship W2147047346A5060586851 @default.
- W2147047346 hasAuthorship W2147047346A5072794458 @default.
- W2147047346 hasAuthorship W2147047346A5086489095 @default.
- W2147047346 hasConcept C104317684 @default.
- W2147047346 hasConcept C185592680 @default.
- W2147047346 hasConcept C202751555 @default.
- W2147047346 hasConcept C2776120743 @default.
- W2147047346 hasConcept C2777230291 @default.
- W2147047346 hasConcept C2777347573 @default.
- W2147047346 hasConcept C2777477808 @default.
- W2147047346 hasConcept C2777752112 @default.
- W2147047346 hasConcept C2778250585 @default.
- W2147047346 hasConcept C2779396153 @default.
- W2147047346 hasConcept C2780035454 @default.
- W2147047346 hasConcept C55493867 @default.
- W2147047346 hasConcept C556039675 @default.
- W2147047346 hasConcept C70721500 @default.
- W2147047346 hasConcept C71924100 @default.
- W2147047346 hasConcept C86803240 @default.
- W2147047346 hasConcept C98274493 @default.
- W2147047346 hasConceptScore W2147047346C104317684 @default.
- W2147047346 hasConceptScore W2147047346C185592680 @default.
- W2147047346 hasConceptScore W2147047346C202751555 @default.
- W2147047346 hasConceptScore W2147047346C2776120743 @default.
- W2147047346 hasConceptScore W2147047346C2777230291 @default.
- W2147047346 hasConceptScore W2147047346C2777347573 @default.
- W2147047346 hasConceptScore W2147047346C2777477808 @default.
- W2147047346 hasConceptScore W2147047346C2777752112 @default.
- W2147047346 hasConceptScore W2147047346C2778250585 @default.
- W2147047346 hasConceptScore W2147047346C2779396153 @default.
- W2147047346 hasConceptScore W2147047346C2780035454 @default.
- W2147047346 hasConceptScore W2147047346C55493867 @default.
- W2147047346 hasConceptScore W2147047346C556039675 @default.
- W2147047346 hasConceptScore W2147047346C70721500 @default.
- W2147047346 hasConceptScore W2147047346C71924100 @default.
- W2147047346 hasConceptScore W2147047346C86803240 @default.
- W2147047346 hasConceptScore W2147047346C98274493 @default.
- W2147047346 hasIssue "36" @default.
- W2147047346 hasLocation W21470473461 @default.
- W2147047346 hasLocation W21470473462 @default.
- W2147047346 hasOpenAccess W2147047346 @default.
- W2147047346 hasPrimaryLocation W21470473461 @default.
- W2147047346 hasRelatedWork W2035308484 @default.
- W2147047346 hasRelatedWork W2147047346 @default.
- W2147047346 hasRelatedWork W2206846792 @default.
- W2147047346 hasRelatedWork W2495192370 @default.
- W2147047346 hasRelatedWork W2894728913 @default.
- W2147047346 hasRelatedWork W2902380624 @default.
- W2147047346 hasRelatedWork W2960698964 @default.
- W2147047346 hasRelatedWork W2999697560 @default.
- W2147047346 hasRelatedWork W3135727723 @default.
- W2147047346 hasRelatedWork W2166421510 @default.
- W2147047346 hasVolume "22" @default.
- W2147047346 isParatext "false" @default.
- W2147047346 isRetracted "false" @default.
- W2147047346 magId "2147047346" @default.
- W2147047346 workType "article" @default.