FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147060719> ?p ?o ?g. }

• W2147060719 endingPage "1042" @default.
• W2147060719 startingPage "1029" @default.
• W2147060719 abstract "Renal fibrosis leads to end-stage renal disease demanding renal replacement therapy because no adequate treatment exists. IFN-γ is an antifibrotic cytokine that may attenuate renal fibrosis. Systemically administered IFN-γ causes side effects that may be prevented by specific drug targeting. Interstitial myofibroblasts are the effector cells in renal fibrogenesis. Here, we tested the hypothesis that cell-specific delivery of IFN-γ to platelet-derived growth factor receptor β (PDGFRβ)-expressing myofibroblasts attenuates fibrosis in an obstructive nephropathy [unilateral ureteral obstruction (UUO)] mouse model. PEGylated IFN-γ conjugated to PDGFRβ-recognizing peptide [(PPB)-polyethylene glycol (PEG)-IFN-γ] was tested in vitro and in vivo for antifibrotic properties and compared with free IFN-γ. PDGFRβ expression was >3-fold increased (P < 0.05) in mouse fibrotic UUO kidneys and colocalized with α-smooth muscle actin-positive (SMA+) myofibroblasts. In vitro, PPB-PEG-IFN-γ significantly inhibited col1a1, col1a2, and α-SMA mRNA expression in TGF-β-activated NIH3T3 fibroblasts (P < 0.05). In vivo, PPB-PEG-IFN-γ specifically accumulated in PDGFRβ-positive myofibroblasts. PPB-PEG-IFN-γ treatment significantly reduced renal collagen I, fibronectin, and α-SMA mRNA and protein expression. Compared with vehicle treatment, PPB-PEG-IFN-γ preserved tubular morphology, reduced interstitial T-cell infiltration, and attenuated lymphangiogenesis (all P < 0.05) without affecting peritubular capillary density. PPB-PEGIFN-γ reduced IFN-γ-related side effects as manifested by reduced major histocompatibility complex class II expression in brain tissue (P < 0.05 vs. free IFN-γ). Our findings demonstrate that specific targeting of IFN-γ to PDGFRβ-expressing myofibroblasts attenuates renal fibrosis and reduces systemic adverse effects.—Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Post, E., Klok, P., vanden Born J. deBorst M.H. vanGoor H. Poelstra K. Hillebrands, J.-L. Selective delivery of IFN-γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis. FASEB J. 29, 1029–1042 (2015). www.fasebj.org" @default.
• W2147060719 created "2016-06-24" @default.
• W2147060719 creator A5003792811 @default.
• W2147060719 creator A5054895217 @default.
• W2147060719 creator A5061968051 @default.
• W2147060719 creator A5063681369 @default.
• W2147060719 creator A5067576914 @default.
• W2147060719 creator A5070728699 @default.
• W2147060719 creator A5072567024 @default.
• W2147060719 creator A5077241319 @default.
• W2147060719 creator A5077283308 @default.
• W2147060719 creator A5088490434 @default.
• W2147060719 creator A5090797998 @default.
• W2147060719 date "2014-12-02" @default.
• W2147060719 modified "2023-10-16" @default.
• W2147060719 title "Selective delivery of IFN‐γ to renal interstitial myofibroblasts: a novel strategy for the treatment of renal fibrosis" @default.
• W2147060719 cites W1490430764 @default.
• W2147060719 cites W1577103697 @default.
• W2147060719 cites W1683525647 @default.
• W2147060719 cites W1684625763 @default.
• W2147060719 cites W1965947268 @default.
• W2147060719 cites W1966538528 @default.
• W2147060719 cites W1976996489 @default.
• W2147060719 cites W1987056502 @default.
• W2147060719 cites W1994887713 @default.
• W2147060719 cites W1998357865 @default.
• W2147060719 cites W2002769663 @default.
• W2147060719 cites W2005449077 @default.
• W2147060719 cites W2011857154 @default.
• W2147060719 cites W2017851358 @default.
• W2147060719 cites W2021165859 @default.
• W2147060719 cites W2021997089 @default.
• W2147060719 cites W2022001248 @default.
• W2147060719 cites W2023750944 @default.
• W2147060719 cites W2023848963 @default.
• W2147060719 cites W2030909091 @default.
• W2147060719 cites W2033432921 @default.
• W2147060719 cites W2035391762 @default.
• W2147060719 cites W2037333379 @default.
• W2147060719 cites W2038153825 @default.
• W2147060719 cites W2043302297 @default.
• W2147060719 cites W2044982400 @default.
• W2147060719 cites W2050515508 @default.
• W2147060719 cites W2052092179 @default.
• W2147060719 cites W2055006636 @default.
• W2147060719 cites W2058250021 @default.
• W2147060719 cites W2063340397 @default.
• W2147060719 cites W2081267985 @default.
• W2147060719 cites W2082270361 @default.
• W2147060719 cites W2084382826 @default.
• W2147060719 cites W2089698754 @default.
• W2147060719 cites W2091846842 @default.
• W2147060719 cites W2101766543 @default.
• W2147060719 cites W2102094290 @default.
• W2147060719 cites W2103565638 @default.
• W2147060719 cites W2104170721 @default.
• W2147060719 cites W2106256269 @default.
• W2147060719 cites W2106469735 @default.
• W2147060719 cites W2108439198 @default.
• W2147060719 cites W2110121929 @default.
• W2147060719 cites W2110408951 @default.
• W2147060719 cites W2113762415 @default.
• W2147060719 cites W2114774093 @default.
• W2147060719 cites W2114920224 @default.
• W2147060719 cites W2116999259 @default.
• W2147060719 cites W2121339421 @default.
• W2147060719 cites W2123233663 @default.
• W2147060719 cites W2123860179 @default.
• W2147060719 cites W2124532149 @default.
• W2147060719 cites W2127336805 @default.
• W2147060719 cites W2130962126 @default.
• W2147060719 cites W2131029325 @default.
• W2147060719 cites W2132228009 @default.
• W2147060719 cites W2134197078 @default.
• W2147060719 cites W2134311399 @default.
• W2147060719 cites W2143349604 @default.
• W2147060719 cites W2155214429 @default.
• W2147060719 cites W2157142589 @default.
• W2147060719 cites W2159513503 @default.
• W2147060719 cites W2166575264 @default.
• W2147060719 cites W2188064034 @default.
• W2147060719 doi "https://doi.org/10.1096/fj.14-258459" @default.
• W2147060719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25466892" @default.
• W2147060719 hasPublicationYear "2014" @default.
• W2147060719 type Work @default.
• W2147060719 sameAs 2147060719 @default.
• W2147060719 citedByCount "65" @default.
• W2147060719 countsByYear W21470607192015 @default.
• W2147060719 countsByYear W21470607192016 @default.
• W2147060719 countsByYear W21470607192017 @default.
• W2147060719 countsByYear W21470607192018 @default.
• W2147060719 countsByYear W21470607192019 @default.
• W2147060719 countsByYear W21470607192020 @default.
• W2147060719 countsByYear W21470607192021 @default.
• W2147060719 countsByYear W21470607192022 @default.
• W2147060719 countsByYear W21470607192023 @default.
• W2147060719 crossrefType "journal-article" @default.
• W2147060719 hasAuthorship W2147060719A5003792811 @default.

• next