FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147069417> ?p ?o ?g. }

• W2147069417 endingPage "1577" @default.
• W2147069417 startingPage "1567" @default.
• W2147069417 abstract "ABSTRACT It has been suggested by many studies that Ca2+ signaling plays an important role in regulating key steps in cell division. In order to study the down stream components of calcium signaling, we have fused the gene of calmodulin (CaM) with that of green fluorescent protein (GFP) and expressed it in HeLa cells. The GFP-CaM protein was found to have similar biochemical properties as the wildtype CaM, and its distribution was also similar to that of the endogenous CaM. Using this GFP-tagged CaM as a probe, we have conducted a detailed examination of the spatialand temporal-dependent redistribution of calmodulin in living mammalian cells during cell division. Our major findings are: (1) high density of CaM was found to distribute in two sub-cellular locations during mitosis; one fraction was concentrated in the spindle poles, while the other was concentrated in the sub-membrane region around the cell. (2) The sub-membrane fraction of CaM became aggregated at the equatorial region where the cleavage furrow was about to form. The timing of this localized aggregation of CaM was closely associated with the onset of cytokinesis. (3) Using a TA-CaM probe, we found that the sub-membrane fraction of CaM near the cleavage furrow was selectively activated during cell division. (4) When we injected a CaM-specific inhibitory peptide into early anaphase cells, cytokinesis was either blocked or severely delayed. These findings suggest that, in addition to Ca2+ ion, CaM may represent a second signal that can also play an active role in determining the positioning and timing of the cleavage furrow formation." @default.
• W2147069417 created "2016-06-24" @default.
• W2147069417 creator A5014315445 @default.
• W2147069417 creator A5021388534 @default.
• W2147069417 creator A5027773946 @default.
• W2147069417 creator A5032495506 @default.
• W2147069417 creator A5069492111 @default.
• W2147069417 creator A5085939432 @default.
• W2147069417 date "1999-05-15" @default.
• W2147069417 modified "2023-10-12" @default.
• W2147069417 title "Dynamic redistribution of calmodulin in HeLa cells during cell division as revealed by a GFP-calmodulin fusion protein technique" @default.
• W2147069417 cites W1513592846 @default.
• W2147069417 cites W1542263802 @default.
• W2147069417 cites W1544043865 @default.
• W2147069417 cites W180174806 @default.
• W2147069417 cites W1807534989 @default.
• W2147069417 cites W1980073547 @default.
• W2147069417 cites W1982301053 @default.
• W2147069417 cites W1982649654 @default.
• W2147069417 cites W1986597110 @default.
• W2147069417 cites W1990402608 @default.
• W2147069417 cites W1992979145 @default.
• W2147069417 cites W1993885918 @default.
• W2147069417 cites W1996961377 @default.
• W2147069417 cites W2003114036 @default.
• W2147069417 cites W2004580933 @default.
• W2147069417 cites W2009329050 @default.
• W2147069417 cites W2014293907 @default.
• W2147069417 cites W2017992257 @default.
• W2147069417 cites W2020293149 @default.
• W2147069417 cites W2022703044 @default.
• W2147069417 cites W2024554691 @default.
• W2147069417 cites W2025796534 @default.
• W2147069417 cites W2026359987 @default.
• W2147069417 cites W2026714762 @default.
• W2147069417 cites W2026790505 @default.
• W2147069417 cites W2032579724 @default.
• W2147069417 cites W2036742051 @default.
• W2147069417 cites W2037683235 @default.
• W2147069417 cites W2047364183 @default.
• W2147069417 cites W2056768008 @default.
• W2147069417 cites W2059020530 @default.
• W2147069417 cites W2061104342 @default.
• W2147069417 cites W2063551001 @default.
• W2147069417 cites W2074785380 @default.
• W2147069417 cites W2077835601 @default.
• W2147069417 cites W2078346131 @default.
• W2147069417 cites W2081113123 @default.
• W2147069417 cites W2081136116 @default.
• W2147069417 cites W2082547186 @default.
• W2147069417 cites W2088233139 @default.
• W2147069417 cites W2116647800 @default.
• W2147069417 cites W2120385383 @default.
• W2147069417 cites W2120772267 @default.
• W2147069417 cites W2121523680 @default.
• W2147069417 cites W2124431471 @default.
• W2147069417 cites W2127275339 @default.
• W2147069417 cites W2133622268 @default.
• W2147069417 cites W2140600255 @default.
• W2147069417 cites W2145049033 @default.
• W2147069417 cites W2162355689 @default.
• W2147069417 cites W2170181290 @default.
• W2147069417 cites W2170784620 @default.
• W2147069417 cites W2291220015 @default.
• W2147069417 cites W2463904825 @default.
• W2147069417 cites W4242292690 @default.
• W2147069417 doi "https://doi.org/10.1242/jcs.112.10.1567" @default.
• W2147069417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10212150" @default.
• W2147069417 hasPublicationYear "1999" @default.
• W2147069417 type Work @default.
• W2147069417 sameAs 2147069417 @default.
• W2147069417 citedByCount "90" @default.
• W2147069417 countsByYear W21470694172012 @default.
• W2147069417 countsByYear W21470694172013 @default.
• W2147069417 countsByYear W21470694172014 @default.
• W2147069417 countsByYear W21470694172015 @default.
• W2147069417 countsByYear W21470694172016 @default.
• W2147069417 countsByYear W21470694172017 @default.
• W2147069417 countsByYear W21470694172018 @default.
• W2147069417 countsByYear W21470694172019 @default.
• W2147069417 countsByYear W21470694172020 @default.
• W2147069417 countsByYear W21470694172021 @default.
• W2147069417 countsByYear W21470694172022 @default.
• W2147069417 countsByYear W21470694172023 @default.
• W2147069417 crossrefType "journal-article" @default.
• W2147069417 hasAuthorship W2147069417A5014315445 @default.
• W2147069417 hasAuthorship W2147069417A5021388534 @default.
• W2147069417 hasAuthorship W2147069417A5027773946 @default.
• W2147069417 hasAuthorship W2147069417A5032495506 @default.
• W2147069417 hasAuthorship W2147069417A5069492111 @default.
• W2147069417 hasAuthorship W2147069417A5085939432 @default.
• W2147069417 hasBestOaLocation W21470694172 @default.
• W2147069417 hasConcept C104317684 @default.
• W2147069417 hasConcept C134867827 @default.
• W2147069417 hasConcept C142613039 @default.
• W2147069417 hasConcept C1491633281 @default.
• W2147069417 hasConcept C151730666 @default.
• W2147069417 hasConcept C175156509 @default.

• next