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- W2147083221 abstract "OBJECTIVE: The objective of this selective EBM review is to determine whether or not modafinil (Provigil ® ) is effective in improving cognitive function in adults with narcolepsy. STUDY DESIGN: Review of all English language primary randomized controlled trials from 1996 to 2010. DATA SOURCES: Double-blind, randomized controlled trials that compared modafinil (Provigil ® ) to a visually matched placebo were found using OVID, MEDLINE, and Cochrane Databases. OUTCOME(S) MEASURED: Each of the three trials assessed the effect of modafinil on cognitive and executive function by Low-Resolution Brain Electromagnetic Tomography (LORETA), and the following assessment tools: Epworth Sleepiness Scale (ESS), Multiple Sleep Latency Test (MSLT), Clinical Global Impression of Change (CGI-C), Maintenance of Wakefulness Test (MWT), Wisconsin Card Sort Test (WSCT) and Pauli Test. RESULTS: Two trials demonstrated a statistically significant improvement in cognitive performance achieved with treatment of modafinil versus placebo, which is related to medial prefrontal activity processes identified by LORETA. The third study demonstrated a significant improvement of executive function achieved with treatment of modafinil. CONCLUSIONS: Based on the three trials, modafinil (Provigil ® ) is effective in improving cognitive function in adults with narcolepsy." @default.
- W2147083221 created "2016-06-24" @default.
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- W2147083221 date "2013-01-01" @default.
- W2147083221 modified "2023-09-26" @default.
- W2147083221 title "Is Modafini l (Provigil®) Effec tive in Improving Cognitive Function in Adults with Narcolepsy?" @default.
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