Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147096811> ?p ?o ?g. }
- W2147096811 endingPage "3125" @default.
- W2147096811 startingPage "3114" @default.
- W2147096811 abstract "Histone deacetylases (HDACs) are targets for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor approved by the U.S. Food and Drug Administration for the treatment of cutaneous T-cell lymphoma. To obtain a better mechanistic understanding of the Sin3/HDAC complex in cancer, we extended its protein-protein interaction network and identified a mutually exclusive pair within the complex. We then assessed the effects of SAHA on the disruption of the complex network through six homologous baits. SAHA perturbs multiple protein interactions and therefore compromises the composition of large parts of the Sin3/HDAC network. A comparison of the effect of SAHA treatment on gene expression in breast cancer cells to a knockdown of the ING2 subunit indicated that a portion of the anticancer effects of SAHA may be attributed to the disruption of ING2's association with the complex. Our dynamic protein interaction network resource provides novel insights into the molecular mechanism of SAHA action and demonstrates the potential for drugs to rewire networks." @default.
- W2147096811 created "2016-06-24" @default.
- W2147096811 creator A5004397208 @default.
- W2147096811 creator A5007277893 @default.
- W2147096811 creator A5025842894 @default.
- W2147096811 creator A5026913912 @default.
- W2147096811 creator A5034566006 @default.
- W2147096811 creator A5057901298 @default.
- W2147096811 creator A5058560687 @default.
- W2147096811 creator A5059586165 @default.
- W2147096811 creator A5067041776 @default.
- W2147096811 creator A5078115158 @default.
- W2147096811 creator A5079392980 @default.
- W2147096811 date "2014-11-01" @default.
- W2147096811 modified "2023-10-18" @default.
- W2147096811 title "Suberoylanilide Hydroxamic Acid (SAHA)-Induced Dynamics of a Human Histone Deacetylase Protein Interaction Network" @default.
- W2147096811 cites W12952247 @default.
- W2147096811 cites W1964372470 @default.
- W2147096811 cites W1964951942 @default.
- W2147096811 cites W1966258042 @default.
- W2147096811 cites W1968327387 @default.
- W2147096811 cites W1972821149 @default.
- W2147096811 cites W1974090542 @default.
- W2147096811 cites W1976470813 @default.
- W2147096811 cites W1990299806 @default.
- W2147096811 cites W1993943756 @default.
- W2147096811 cites W2000255462 @default.
- W2147096811 cites W2000548132 @default.
- W2147096811 cites W2001465534 @default.
- W2147096811 cites W2007139310 @default.
- W2147096811 cites W2007824099 @default.
- W2147096811 cites W2014364284 @default.
- W2147096811 cites W2022522821 @default.
- W2147096811 cites W2026465178 @default.
- W2147096811 cites W2029553332 @default.
- W2147096811 cites W2045868295 @default.
- W2147096811 cites W2046696981 @default.
- W2147096811 cites W2047918711 @default.
- W2147096811 cites W2073225651 @default.
- W2147096811 cites W2075428343 @default.
- W2147096811 cites W2078138443 @default.
- W2147096811 cites W2099060358 @default.
- W2147096811 cites W2099415899 @default.
- W2147096811 cites W2104535331 @default.
- W2147096811 cites W2112238103 @default.
- W2147096811 cites W2113833115 @default.
- W2147096811 cites W2116807043 @default.
- W2147096811 cites W2118862408 @default.
- W2147096811 cites W2127967682 @default.
- W2147096811 cites W2130638154 @default.
- W2147096811 cites W2135306073 @default.
- W2147096811 cites W2135830745 @default.
- W2147096811 cites W2146432662 @default.
- W2147096811 cites W2149066102 @default.
- W2147096811 cites W2153247544 @default.
- W2147096811 cites W2155563035 @default.
- W2147096811 cites W2161345806 @default.
- W2147096811 cites W2170989872 @default.
- W2147096811 cites W2414432447 @default.
- W2147096811 doi "https://doi.org/10.1074/mcp.m113.037127" @default.
- W2147096811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4223495" @default.
- W2147096811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25073741" @default.
- W2147096811 hasPublicationYear "2014" @default.
- W2147096811 type Work @default.
- W2147096811 sameAs 2147096811 @default.
- W2147096811 citedByCount "24" @default.
- W2147096811 countsByYear W21470968112015 @default.
- W2147096811 countsByYear W21470968112016 @default.
- W2147096811 countsByYear W21470968112017 @default.
- W2147096811 countsByYear W21470968112018 @default.
- W2147096811 countsByYear W21470968112019 @default.
- W2147096811 countsByYear W21470968112020 @default.
- W2147096811 countsByYear W21470968112021 @default.
- W2147096811 countsByYear W21470968112022 @default.
- W2147096811 countsByYear W21470968112023 @default.
- W2147096811 crossrefType "journal-article" @default.
- W2147096811 hasAuthorship W2147096811A5004397208 @default.
- W2147096811 hasAuthorship W2147096811A5007277893 @default.
- W2147096811 hasAuthorship W2147096811A5025842894 @default.
- W2147096811 hasAuthorship W2147096811A5026913912 @default.
- W2147096811 hasAuthorship W2147096811A5034566006 @default.
- W2147096811 hasAuthorship W2147096811A5057901298 @default.
- W2147096811 hasAuthorship W2147096811A5058560687 @default.
- W2147096811 hasAuthorship W2147096811A5059586165 @default.
- W2147096811 hasAuthorship W2147096811A5067041776 @default.
- W2147096811 hasAuthorship W2147096811A5078115158 @default.
- W2147096811 hasAuthorship W2147096811A5079392980 @default.
- W2147096811 hasBestOaLocation W21470968111 @default.
- W2147096811 hasConcept C104292427 @default.
- W2147096811 hasConcept C104317684 @default.
- W2147096811 hasConcept C11804247 @default.
- W2147096811 hasConcept C173396325 @default.
- W2147096811 hasConcept C185592680 @default.
- W2147096811 hasConcept C2776202225 @default.
- W2147096811 hasConcept C2776262904 @default.
- W2147096811 hasConcept C2776281265 @default.
- W2147096811 hasConcept C2778305200 @default.
- W2147096811 hasConcept C502942594 @default.