Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147099224> ?p ?o ?g. }
- W2147099224 endingPage "1876" @default.
- W2147099224 startingPage "1864" @default.
- W2147099224 abstract "X chromosome inactivation (XCI) achieves dosage balance in mammals by repressing one of two X chromosomes in females. During XCI, the long noncoding Xist RNA and Polycomb proteins spread along the inactive X (Xi) to initiate chromosome-wide silencing. Although inactivation is known to commence at the X-inactivation center (Xic), how it propagates remains unknown. Here, we examine allele-specific binding of Polycomb repressive complex 2 (PRC2) and chromatin composition during XCI and generate a chromosome-wide profile of Xi and Xa (active X) at nucleosome-resolution. Initially, Polycomb proteins are localized to ∼150 strong sites along the X and concentrated predominantly within bivalent domains coinciding with CpG islands (canonical sites). As XCI proceeds, ∼4000 noncanonical sites are recruited, most of which are intergenic, nonbivalent, and lack CpG islands. Polycomb sites are depleted of LINE repeats but enriched for SINEs and simple repeats. Noncanonical sites cluster around the ∼150 strong sites, and their H3K27me3 levels reflect a graded concentration originating from strong sites. This suggests that PRC2 and H3K27 methylation spread along a gradient unique to XCI. We propose that XCI is governed by a hierarchy of defined Polycomb stations that spread H3K27 methylation in cis." @default.
- W2147099224 created "2016-06-24" @default.
- W2147099224 creator A5001741248 @default.
- W2147099224 creator A5003288507 @default.
- W2147099224 creator A5007941136 @default.
- W2147099224 creator A5014184589 @default.
- W2147099224 creator A5024856047 @default.
- W2147099224 creator A5027738191 @default.
- W2147099224 creator A5085506660 @default.
- W2147099224 date "2012-09-04" @default.
- W2147099224 modified "2023-10-17" @default.
- W2147099224 title "Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations" @default.
- W2147099224 cites W1535914077 @default.
- W2147099224 cites W1968931043 @default.
- W2147099224 cites W1973279069 @default.
- W2147099224 cites W1977943782 @default.
- W2147099224 cites W1994943629 @default.
- W2147099224 cites W1995325727 @default.
- W2147099224 cites W2000949700 @default.
- W2147099224 cites W2004916637 @default.
- W2147099224 cites W2005501593 @default.
- W2147099224 cites W2007941919 @default.
- W2147099224 cites W2011181841 @default.
- W2147099224 cites W2015416439 @default.
- W2147099224 cites W2017840637 @default.
- W2147099224 cites W2020958409 @default.
- W2147099224 cites W2034518808 @default.
- W2147099224 cites W2037917566 @default.
- W2147099224 cites W2043317822 @default.
- W2147099224 cites W2047333953 @default.
- W2147099224 cites W2057950655 @default.
- W2147099224 cites W2060199527 @default.
- W2147099224 cites W2062313490 @default.
- W2147099224 cites W2073048705 @default.
- W2147099224 cites W2074041443 @default.
- W2147099224 cites W2074324848 @default.
- W2147099224 cites W2091260004 @default.
- W2147099224 cites W2101378716 @default.
- W2147099224 cites W2103419911 @default.
- W2147099224 cites W2111473969 @default.
- W2147099224 cites W2118239133 @default.
- W2147099224 cites W2118812779 @default.
- W2147099224 cites W2118998259 @default.
- W2147099224 cites W2130135559 @default.
- W2147099224 cites W2131455394 @default.
- W2147099224 cites W2140847047 @default.
- W2147099224 cites W2145091349 @default.
- W2147099224 cites W2145598239 @default.
- W2147099224 cites W2147568705 @default.
- W2147099224 cites W2157701113 @default.
- W2147099224 cites W2158610627 @default.
- W2147099224 cites W2169910722 @default.
- W2147099224 cites W3024125022 @default.
- W2147099224 cites W59123347 @default.
- W2147099224 doi "https://doi.org/10.1101/gr.133751.111" @default.
- W2147099224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3460182" @default.
- W2147099224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22948768" @default.
- W2147099224 hasPublicationYear "2012" @default.
- W2147099224 type Work @default.
- W2147099224 sameAs 2147099224 @default.
- W2147099224 citedByCount "142" @default.
- W2147099224 countsByYear W21470992242013 @default.
- W2147099224 countsByYear W21470992242014 @default.
- W2147099224 countsByYear W21470992242015 @default.
- W2147099224 countsByYear W21470992242016 @default.
- W2147099224 countsByYear W21470992242017 @default.
- W2147099224 countsByYear W21470992242018 @default.
- W2147099224 countsByYear W21470992242019 @default.
- W2147099224 countsByYear W21470992242020 @default.
- W2147099224 countsByYear W21470992242021 @default.
- W2147099224 countsByYear W21470992242022 @default.
- W2147099224 crossrefType "journal-article" @default.
- W2147099224 hasAuthorship W2147099224A5001741248 @default.
- W2147099224 hasAuthorship W2147099224A5003288507 @default.
- W2147099224 hasAuthorship W2147099224A5007941136 @default.
- W2147099224 hasAuthorship W2147099224A5014184589 @default.
- W2147099224 hasAuthorship W2147099224A5024856047 @default.
- W2147099224 hasAuthorship W2147099224A5027738191 @default.
- W2147099224 hasAuthorship W2147099224A5085506660 @default.
- W2147099224 hasBestOaLocation W21470992241 @default.
- W2147099224 hasConcept C104317684 @default.
- W2147099224 hasConcept C110411900 @default.
- W2147099224 hasConcept C150194340 @default.
- W2147099224 hasConcept C158448853 @default.
- W2147099224 hasConcept C190727270 @default.
- W2147099224 hasConcept C2776915012 @default.
- W2147099224 hasConcept C2777116130 @default.
- W2147099224 hasConcept C30481170 @default.
- W2147099224 hasConcept C35158069 @default.
- W2147099224 hasConcept C4323932 @default.
- W2147099224 hasConcept C50171091 @default.
- W2147099224 hasConcept C54355233 @default.
- W2147099224 hasConcept C552990157 @default.
- W2147099224 hasConcept C83640560 @default.
- W2147099224 hasConcept C84772758 @default.
- W2147099224 hasConcept C86339819 @default.
- W2147099224 hasConcept C86803240 @default.
- W2147099224 hasConcept C95444343 @default.