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- W2147103319 abstract "textabstractMultiple sclerosis (MS) is a chronic neurological disease thataffects the brain and spinal cord. It is thought that MS is anautoimmune disease, where a person’s immune system reacts toits own body, namely the myelin sheath that surrounds the nervecells. Disease symptoms include vision problems, imbalance andparalysis of the limbs. The exact cause of MS is still unknown, andtherapies without adverse effects are not available. Substantialevidence suggests that the disease arises as a result of a certaincombination of environmental, genetic and infectiouscircumstances. We hypothesize that herpesviruses create arepertoire of autoreactive T-cells, which play a crucial role in thedemyelination process. To unravel the contribution of theseautoreactive T-cells to the pathogenesis of MS, the commonmarmoset is used as an animal model for MS. The commonmarmoset is a relevant model with a close genetic andimmunological proximity to humans, and it resembles thedisease in its clinical and pathological presentation. This thesisdescribes how the common marmoset model for MS is refinedethically, mechanistically, and conceptually to better understandthe underlying pathogenic processes, as well as to develop andimprove new targets for MS therapy." @default.
- W2147103319 created "2016-06-24" @default.
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- W2147103319 date "2012-05-23" @default.
- W2147103319 modified "2023-09-27" @default.
- W2147103319 title "Mechanistic refinement of the common marmoset model for multiple sclerosis" @default.
- W2147103319 hasPublicationYear "2012" @default.
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