Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147103638> ?p ?o ?g. }
- W2147103638 endingPage "5617" @default.
- W2147103638 startingPage "5610" @default.
- W2147103638 abstract "Abstract Ovarian cancer is the most lethal gynecologic malignancy, often diagnosed at advanced stage leading to poor prognosis. In the study reported here, magnetic resonance imaging and near-infrared reflectance imaging were applied for in vivo analysis of two competing endocytic pathways affecting retention of bifunctional daidzein-bovine serum albumin (BSA)–based contrast media by human epithelial ovarian carcinoma cells. Suppression of caveolae-mediated uptake using nystatin or by BSA competition significantly enhanced daidzein-BSA-GdDTPA/CyTE777 uptake by tumor cells in vitro. In vivo, perivascular myofibroblasts generated an effective perivascular barrier excluding delivery of BSA-GdDTPA/CyTE777 to tumor cells. The ability to manipulate caveolae-mediated sequestration of albumin by perivascular tumor myofibroblasts allowed us to effectively overcome this tumor-stroma barrier, increasing delivery of daidzein-BSA-GdDTPA/CyTE777 to the tumor cells in tumor xenografts. Thus, both in vitro and in vivo, endocytosis of daidzein-BSA-GdDTPA/CyTE777 by ovarian carcinoma cells was augmented by albumin or by nystatin. In view of the cardinal role of albumin in affecting the availability and pharmacokinetics of drugs, this approach could potentially also facilitate the delivery of therapeutics and contrast media to tumor cells. [Cancer Res 2009;69(13):5610–7]" @default.
- W2147103638 created "2016-06-24" @default.
- W2147103638 creator A5007851455 @default.
- W2147103638 creator A5037852773 @default.
- W2147103638 creator A5057486827 @default.
- W2147103638 creator A5071887646 @default.
- W2147103638 creator A5078171504 @default.
- W2147103638 creator A5083944898 @default.
- W2147103638 date "2009-07-01" @default.
- W2147103638 modified "2023-09-24" @default.
- W2147103638 title "Harnessing Competing Endocytic Pathways for Overcoming the Tumor-Blood Barrier: Magnetic Resonance Imaging and Near-Infrared Imaging of Bifunctional Contrast Media" @default.
- W2147103638 cites W1797116645 @default.
- W2147103638 cites W1965702146 @default.
- W2147103638 cites W1979598229 @default.
- W2147103638 cites W1980650234 @default.
- W2147103638 cites W1987902845 @default.
- W2147103638 cites W1990585331 @default.
- W2147103638 cites W1995492424 @default.
- W2147103638 cites W2002950604 @default.
- W2147103638 cites W2004442010 @default.
- W2147103638 cites W2019405466 @default.
- W2147103638 cites W2024073471 @default.
- W2147103638 cites W2025126790 @default.
- W2147103638 cites W2030837679 @default.
- W2147103638 cites W2030864157 @default.
- W2147103638 cites W2034109465 @default.
- W2147103638 cites W2041066582 @default.
- W2147103638 cites W2048640572 @default.
- W2147103638 cites W2062809449 @default.
- W2147103638 cites W2069514245 @default.
- W2147103638 cites W2081579465 @default.
- W2147103638 cites W2082421654 @default.
- W2147103638 cites W2087399689 @default.
- W2147103638 cites W2088261391 @default.
- W2147103638 cites W2088547883 @default.
- W2147103638 cites W2088812802 @default.
- W2147103638 cites W2097818582 @default.
- W2147103638 cites W2099853494 @default.
- W2147103638 cites W2101037339 @default.
- W2147103638 cites W2105438153 @default.
- W2147103638 cites W2109515530 @default.
- W2147103638 cites W2113247975 @default.
- W2147103638 cites W2116765336 @default.
- W2147103638 cites W2116843275 @default.
- W2147103638 cites W2127373755 @default.
- W2147103638 cites W2131909847 @default.
- W2147103638 cites W2140342568 @default.
- W2147103638 cites W2144536924 @default.
- W2147103638 cites W2148258472 @default.
- W2147103638 cites W2149032995 @default.
- W2147103638 cites W2152175544 @default.
- W2147103638 cites W2156934935 @default.
- W2147103638 cites W2162542545 @default.
- W2147103638 cites W2169039001 @default.
- W2147103638 cites W2171128761 @default.
- W2147103638 doi "https://doi.org/10.1158/0008-5472.can-08-4967" @default.
- W2147103638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2730440" @default.
- W2147103638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19509228" @default.
- W2147103638 hasPublicationYear "2009" @default.
- W2147103638 type Work @default.
- W2147103638 sameAs 2147103638 @default.
- W2147103638 citedByCount "10" @default.
- W2147103638 countsByYear W21471036382013 @default.
- W2147103638 countsByYear W21471036382014 @default.
- W2147103638 countsByYear W21471036382017 @default.
- W2147103638 countsByYear W21471036382020 @default.
- W2147103638 countsByYear W21471036382022 @default.
- W2147103638 crossrefType "journal-article" @default.
- W2147103638 hasAuthorship W2147103638A5007851455 @default.
- W2147103638 hasAuthorship W2147103638A5037852773 @default.
- W2147103638 hasAuthorship W2147103638A5057486827 @default.
- W2147103638 hasAuthorship W2147103638A5071887646 @default.
- W2147103638 hasAuthorship W2147103638A5078171504 @default.
- W2147103638 hasAuthorship W2147103638A5083944898 @default.
- W2147103638 hasBestOaLocation W21471036381 @default.
- W2147103638 hasConcept C121608353 @default.
- W2147103638 hasConcept C126322002 @default.
- W2147103638 hasConcept C142724271 @default.
- W2147103638 hasConcept C1491633281 @default.
- W2147103638 hasConcept C150903083 @default.
- W2147103638 hasConcept C185592680 @default.
- W2147103638 hasConcept C202751555 @default.
- W2147103638 hasConcept C207001950 @default.
- W2147103638 hasConcept C2776125364 @default.
- W2147103638 hasConcept C2779540182 @default.
- W2147103638 hasConcept C2780427987 @default.
- W2147103638 hasConcept C28005876 @default.
- W2147103638 hasConcept C502942594 @default.
- W2147103638 hasConcept C55493867 @default.
- W2147103638 hasConcept C71924100 @default.
- W2147103638 hasConcept C79747257 @default.
- W2147103638 hasConcept C86803240 @default.
- W2147103638 hasConcept C86807702 @default.
- W2147103638 hasConceptScore W2147103638C121608353 @default.
- W2147103638 hasConceptScore W2147103638C126322002 @default.
- W2147103638 hasConceptScore W2147103638C142724271 @default.
- W2147103638 hasConceptScore W2147103638C1491633281 @default.
- W2147103638 hasConceptScore W2147103638C150903083 @default.