FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147111434> ?p ?o ?g. }

• W2147111434 endingPage "866" @default.
• W2147111434 startingPage "859" @default.
• W2147111434 abstract "Because of the frequent use of L-tryptophan (L-Trp) in dietary supplements, determination of the no-observed-adverse-effect-level is desirable for public health purposes. We therefore assessed the no-observed-adverse-effect-level for L-Trp and attempted to identify a surrogate biomarker for excess L-Trp in healthy humans. A randomized, double-blind, placebo-controlled, crossover intervention study was performed in 17 apparently healthy Japanese women aged 18-26 y with a BMI of ≈ 20 kg/m(2). The participants were randomly assigned to receive placebo (0 g/d) or 1.0, 2.0, 3.0, 4.0, or 5.0 g/d of L-Trp for 21 d each with a 5-wk washout period between trials. Food intake, body weight, general biomarkers in blood and urine, and amino acid composition in blood and urine were not affected by any dose of L-Trp. Administration of up to 5.0 g/d L-Trp had no effect on a profile of mood states category measurement. The urinary excretion of nicotinamide and its catabolites increased in proportion to the ingested amounts of L-Trp, indicating that participants could normally metabolize this amino acid. The urinary excretion of L-tryptophan metabolites, including kynurenine (Kyn), anthranilic acid, kynurenic acid, 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid, and quinolinic acid (QA), all of which are intermediates of the L-TRP→Kyn→QA pathway, was in proportion to L-Trp loading. The response of 3-HK was the most characteristic of these L-Trp metabolites. This finding suggests that the urinary excretion of 3-HK is a good surrogate biomarker for excess L-Trp ingestion." @default.
• W2147111434 created "2016-06-24" @default.
• W2147111434 creator A5009725511 @default.
• W2147111434 creator A5030547192 @default.
• W2147111434 creator A5039637864 @default.
• W2147111434 creator A5055313604 @default.
• W2147111434 creator A5056420978 @default.
• W2147111434 creator A5072287585 @default.
• W2147111434 date "2013-06-01" @default.
• W2147111434 modified "2023-10-01" @default.
• W2147111434 title "Supplementing Healthy Women with up to 5.0 g/d of L-Tryptophan Has No Adverse Effects" @default.
• W2147111434 cites W1016980201 @default.
• W2147111434 cites W1505887853 @default.
• W2147111434 cites W1571431689 @default.
• W2147111434 cites W1572549182 @default.
• W2147111434 cites W1681194655 @default.
• W2147111434 cites W1894298603 @default.
• W2147111434 cites W1900952937 @default.
• W2147111434 cites W1903640084 @default.
• W2147111434 cites W1912630203 @default.
• W2147111434 cites W1913837952 @default.
• W2147111434 cites W1921641295 @default.
• W2147111434 cites W1942982649 @default.
• W2147111434 cites W1952415475 @default.
• W2147111434 cites W1981682711 @default.
• W2147111434 cites W1983024303 @default.
• W2147111434 cites W1995533305 @default.
• W2147111434 cites W1998029141 @default.
• W2147111434 cites W2002953199 @default.
• W2147111434 cites W2006838793 @default.
• W2147111434 cites W2009278722 @default.
• W2147111434 cites W2016134350 @default.
• W2147111434 cites W2024413504 @default.
• W2147111434 cites W2026502933 @default.
• W2147111434 cites W2027884822 @default.
• W2147111434 cites W2032949603 @default.
• W2147111434 cites W2044065510 @default.
• W2147111434 cites W2051088649 @default.
• W2147111434 cites W2052564513 @default.
• W2147111434 cites W2053281425 @default.
• W2147111434 cites W2055014902 @default.
• W2147111434 cites W2058229873 @default.
• W2147111434 cites W2060556634 @default.
• W2147111434 cites W2064987952 @default.
• W2147111434 cites W2068037785 @default.
• W2147111434 cites W2069957341 @default.
• W2147111434 cites W2074238209 @default.
• W2147111434 cites W2075082413 @default.
• W2147111434 cites W2076857188 @default.
• W2147111434 cites W2079339637 @default.
• W2147111434 cites W2095324115 @default.
• W2147111434 cites W2139118065 @default.
• W2147111434 cites W2141679962 @default.
• W2147111434 cites W2149763740 @default.
• W2147111434 cites W2154877445 @default.
• W2147111434 cites W2164218441 @default.
• W2147111434 cites W2173679608 @default.
• W2147111434 cites W2399210661 @default.
• W2147111434 cites W2414482568 @default.
• W2147111434 cites W4298333102 @default.
• W2147111434 cites W58939410 @default.
• W2147111434 doi "https://doi.org/10.3945/jn.112.173823" @default.
• W2147111434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23616514" @default.
• W2147111434 hasPublicationYear "2013" @default.
• W2147111434 type Work @default.
• W2147111434 sameAs 2147111434 @default.
• W2147111434 citedByCount "45" @default.
• W2147111434 countsByYear W21471114342013 @default.
• W2147111434 countsByYear W21471114342014 @default.
• W2147111434 countsByYear W21471114342015 @default.
• W2147111434 countsByYear W21471114342016 @default.
• W2147111434 countsByYear W21471114342017 @default.
• W2147111434 countsByYear W21471114342018 @default.
• W2147111434 countsByYear W21471114342019 @default.
• W2147111434 countsByYear W21471114342020 @default.
• W2147111434 countsByYear W21471114342021 @default.
• W2147111434 countsByYear W21471114342022 @default.
• W2147111434 countsByYear W21471114342023 @default.
• W2147111434 crossrefType "journal-article" @default.
• W2147111434 hasAuthorship W2147111434A5009725511 @default.
• W2147111434 hasAuthorship W2147111434A5030547192 @default.
• W2147111434 hasAuthorship W2147111434A5039637864 @default.
• W2147111434 hasAuthorship W2147111434A5055313604 @default.
• W2147111434 hasAuthorship W2147111434A5056420978 @default.
• W2147111434 hasAuthorship W2147111434A5072287585 @default.
• W2147111434 hasBestOaLocation W21471114341 @default.
• W2147111434 hasConcept C10146269 @default.
• W2147111434 hasConcept C126322002 @default.
• W2147111434 hasConcept C134018914 @default.
• W2147111434 hasConcept C142724271 @default.
• W2147111434 hasConcept C185592680 @default.
• W2147111434 hasConcept C204787440 @default.
• W2147111434 hasConcept C27081682 @default.
• W2147111434 hasConcept C2776706248 @default.
• W2147111434 hasConcept C2776841986 @default.
• W2147111434 hasConcept C2777503454 @default.
• W2147111434 hasConcept C2777896816 @default.
• W2147111434 hasConcept C2779187253 @default.

• next