Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147124328> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2147124328 endingPage "546" @default.
- W2147124328 startingPage "543" @default.
- W2147124328 abstract "Allograft rejection (AR) and graft-versus-host disease (GvHD) are serious complications following transplantation. Micro-RNAs (miRNAs) have recently been identified as key players in the regulation of these disorders. Because intravenous immunoglobulin (IVIg) has shown therapeutic potential for the prophylaxis and post-transplant reduction of AR and GvHD, we hypothesized that the effect of IVIg could result from the modulation of specific miRNA expression. To identify such miRNA, we performed mixed lymphocyte reactions (MLRs) as an in vitro model of AR and GvHD, with or without IVIg. We herein show that IVIg strongly inhibits the MLRs. This inhibition is associated with a modulation in the expression of miRNAs implicated in the regulation of pro-inflammatory cytokine (IL-2, IL-6, IFN-γ) and costimulatory molecule (CD80) expression. We propose that these identified miRNAs could represent potential therapeutic targets for the prevention and therapy of AR and GvHD." @default.
- W2147124328 created "2016-06-24" @default.
- W2147124328 creator A5014425684 @default.
- W2147124328 creator A5057947476 @default.
- W2147124328 creator A5060138583 @default.
- W2147124328 date "2015-04-23" @default.
- W2147124328 modified "2023-10-04" @default.
- W2147124328 title "Use of IVIg to identify potential miRNA targets for allograft rejection and GvHD therapy" @default.
- W2147124328 cites W1519739419 @default.
- W2147124328 cites W1687726755 @default.
- W2147124328 cites W1750499197 @default.
- W2147124328 cites W1923016962 @default.
- W2147124328 cites W2014869583 @default.
- W2147124328 cites W2025302700 @default.
- W2147124328 cites W2027996995 @default.
- W2147124328 cites W2040093370 @default.
- W2147124328 cites W2074995759 @default.
- W2147124328 cites W2100381854 @default.
- W2147124328 cites W2135778528 @default.
- W2147124328 cites W2152541651 @default.
- W2147124328 cites W2158476280 @default.
- W2147124328 cites W2159327612 @default.
- W2147124328 cites W2166277046 @default.
- W2147124328 cites W2167966317 @default.
- W2147124328 cites W2616639792 @default.
- W2147124328 doi "https://doi.org/10.1111/ctr.12549" @default.
- W2147124328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25832981" @default.
- W2147124328 hasPublicationYear "2015" @default.
- W2147124328 type Work @default.
- W2147124328 sameAs 2147124328 @default.
- W2147124328 citedByCount "2" @default.
- W2147124328 countsByYear W21471243282020 @default.
- W2147124328 countsByYear W21471243282023 @default.
- W2147124328 crossrefType "journal-article" @default.
- W2147124328 hasAuthorship W2147124328A5014425684 @default.
- W2147124328 hasAuthorship W2147124328A5057947476 @default.
- W2147124328 hasAuthorship W2147124328A5060138583 @default.
- W2147124328 hasConcept C104317684 @default.
- W2147124328 hasConcept C126322002 @default.
- W2147124328 hasConcept C145059251 @default.
- W2147124328 hasConcept C154317977 @default.
- W2147124328 hasConcept C202751555 @default.
- W2147124328 hasConcept C203014093 @default.
- W2147124328 hasConcept C2778297628 @default.
- W2147124328 hasConcept C2778690821 @default.
- W2147124328 hasConcept C2779972918 @default.
- W2147124328 hasConcept C2911091166 @default.
- W2147124328 hasConcept C39347974 @default.
- W2147124328 hasConcept C502942594 @default.
- W2147124328 hasConcept C55493867 @default.
- W2147124328 hasConcept C71924100 @default.
- W2147124328 hasConcept C86803240 @default.
- W2147124328 hasConceptScore W2147124328C104317684 @default.
- W2147124328 hasConceptScore W2147124328C126322002 @default.
- W2147124328 hasConceptScore W2147124328C145059251 @default.
- W2147124328 hasConceptScore W2147124328C154317977 @default.
- W2147124328 hasConceptScore W2147124328C202751555 @default.
- W2147124328 hasConceptScore W2147124328C203014093 @default.
- W2147124328 hasConceptScore W2147124328C2778297628 @default.
- W2147124328 hasConceptScore W2147124328C2778690821 @default.
- W2147124328 hasConceptScore W2147124328C2779972918 @default.
- W2147124328 hasConceptScore W2147124328C2911091166 @default.
- W2147124328 hasConceptScore W2147124328C39347974 @default.
- W2147124328 hasConceptScore W2147124328C502942594 @default.
- W2147124328 hasConceptScore W2147124328C55493867 @default.
- W2147124328 hasConceptScore W2147124328C71924100 @default.
- W2147124328 hasConceptScore W2147124328C86803240 @default.
- W2147124328 hasIssue "6" @default.
- W2147124328 hasLocation W21471243281 @default.
- W2147124328 hasLocation W21471243282 @default.
- W2147124328 hasOpenAccess W2147124328 @default.
- W2147124328 hasPrimaryLocation W21471243281 @default.
- W2147124328 hasRelatedWork W1513271561 @default.
- W2147124328 hasRelatedWork W1984832962 @default.
- W2147124328 hasRelatedWork W2023834531 @default.
- W2147124328 hasRelatedWork W2154294188 @default.
- W2147124328 hasRelatedWork W2164926189 @default.
- W2147124328 hasRelatedWork W2360390751 @default.
- W2147124328 hasRelatedWork W2535807463 @default.
- W2147124328 hasRelatedWork W2998343095 @default.
- W2147124328 hasRelatedWork W2998722864 @default.
- W2147124328 hasRelatedWork W4232592029 @default.
- W2147124328 hasVolume "29" @default.
- W2147124328 isParatext "false" @default.
- W2147124328 isRetracted "false" @default.
- W2147124328 magId "2147124328" @default.
- W2147124328 workType "article" @default.