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• W2147128496 endingPage "R354" @default.
• W2147128496 startingPage "R343" @default.
• W2147128496 abstract "A reduction of heat loss to the environment through increased cutaneous vasoconstrictor (CVC) sympathetic outflow contributes to elevated body temperature during fever. We determined the role of neurons in the dorsomedial hypothalamus (DMH) in increases in CVC sympathetic tone evoked by PGE 2 into the preoptic area (POA) in chloralose/urethane-anesthetized rats. The frequency of axonal action potentials of CVC sympathetic ganglion cells recorded from the surface of the tail artery was increased by 1.8 Hz following nanoinjections of bicuculline (50 pmol) into the DMH. PGE 2 nanoinjection into the POA elicited a similar excitation of tail CVC neurons (+2.1 Hz). Subsequent to PGE 2 into the POA, muscimol (400 pmol/side) into the DMH did not alter the activity of tail CVC neurons. Inhibition of neurons in the rostral raphé pallidus (rRPa) eliminated the spontaneous discharge of tail CVC neurons but only reduced the PGE 2 -evoked activity. Residual activity was abolished by subsequent muscimol into the rostral ventrolateral medulla. Transections through the neuraxis caudal to the POA increased the activity of tail CVC neurons, which were sustained through transections caudal to DMH. We conclude that while activation of neurons in the DMH is sufficient to activate tail CVC neurons, it is not necessary for their PGE 2 -evoked activity. These results support a CVC component of increased core temperature elicited by PGE 2 in POA that arises from relief of a tonic inhibition from neurons in POA of CVC sympathetic premotor neurons in rRPa and is dependent on the excitation of CVC premotor neurons from a site caudal to DMH." @default.
• W2147128496 created "2016-06-24" @default.
• W2147128496 creator A5065859585 @default.
• W2147128496 creator A5068741363 @default.
• W2147128496 creator A5078989242 @default.
• W2147128496 date "2008-07-01" @default.
• W2147128496 modified "2023-10-15" @default.
• W2147128496 title "Central pathway for spontaneous and prostaglandin E₂-evoked cutaneous vasoconstriction" @default.
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• W2147128496 doi "https://doi.org/10.1152/ajpregu.00115.2008" @default.
• W2147128496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2494816" @default.
• W2147128496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18463193" @default.
• W2147128496 hasPublicationYear "2008" @default.
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