FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147130888> ?p ?o ?g. }

• W2147130888 endingPage "1521" @default.
• W2147130888 startingPage "1512" @default.
• W2147130888 abstract "Formin family proteins act as processive cappers of actin filaments, and determine the dynamics of a number of intracellular processes that are based on actin polymerization. The rate of filament growth upon processive capping varies within a broad range depending on the formin type and presence of profilin. While FH2 domains of various formins slow down polymerization by different extents, the FH1-FH2 domains in conjunction with profilin accelerate the reaction. Study of the physical mechanism of processive capping is vital for understanding the intracellular actin dynamics. We propose a model predicting that variation of a single physical parameter—the effective elastic energy of the formin-capped barbed end—results in the observed diversity of the polymerization rates. The model accounts for the whole range of the experimental results including the drastic slowing down of polymerization by FH2 of Cdc12 formin and the 4.5-fold acceleration of the reaction by FH1-FH2 of mDai1 formin in the presence of profilin. Fitting the theoretical predictions to the experimental curves provides the values of the effective elastic energies of different formin-barbed end complexes." @default.
• W2147130888 created "2016-06-24" @default.
• W2147130888 creator A5006020430 @default.
• W2147130888 creator A5062465955 @default.
• W2147130888 date "2007-03-01" @default.
• W2147130888 modified "2023-09-30" @default.
• W2147130888 title "Actin Polymerization upon Processive Capping by Formin: A Model for Slowing and Acceleration" @default.
• W2147130888 cites W1557401044 @default.
• W2147130888 cites W1966935815 @default.
• W2147130888 cites W1968603501 @default.
• W2147130888 cites W1997419253 @default.
• W2147130888 cites W2008282204 @default.
• W2147130888 cites W2009392340 @default.
• W2147130888 cites W2010946210 @default.
• W2147130888 cites W2011343310 @default.
• W2147130888 cites W2016727199 @default.
• W2147130888 cites W2018659688 @default.
• W2147130888 cites W2019559746 @default.
• W2147130888 cites W2022034668 @default.
• W2147130888 cites W2024095351 @default.
• W2147130888 cites W2029042183 @default.
• W2147130888 cites W2030768863 @default.
• W2147130888 cites W2040991028 @default.
• W2147130888 cites W2047014275 @default.
• W2147130888 cites W2047853156 @default.
• W2147130888 cites W2051964014 @default.
• W2147130888 cites W2052115941 @default.
• W2147130888 cites W2055466007 @default.
• W2147130888 cites W2056902230 @default.
• W2147130888 cites W2064071063 @default.
• W2147130888 cites W2070119451 @default.
• W2147130888 cites W2085603990 @default.
• W2147130888 cites W2096358322 @default.
• W2147130888 cites W2103966138 @default.
• W2147130888 cites W2108167818 @default.
• W2147130888 cites W2126496496 @default.
• W2147130888 cites W2129890878 @default.
• W2147130888 cites W2141075109 @default.
• W2147130888 cites W2153290005 @default.
• W2147130888 cites W4245110828 @default.
• W2147130888 doi "https://doi.org/10.1529/biophysj.106.098459" @default.
• W2147130888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1796842" @default.
• W2147130888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17158576" @default.
• W2147130888 hasPublicationYear "2007" @default.
• W2147130888 type Work @default.
• W2147130888 sameAs 2147130888 @default.
• W2147130888 citedByCount "26" @default.
• W2147130888 countsByYear W21471308882012 @default.
• W2147130888 countsByYear W21471308882013 @default.
• W2147130888 countsByYear W21471308882015 @default.
• W2147130888 countsByYear W21471308882016 @default.
• W2147130888 countsByYear W21471308882017 @default.
• W2147130888 countsByYear W21471308882018 @default.
• W2147130888 countsByYear W21471308882019 @default.
• W2147130888 countsByYear W21471308882020 @default.
• W2147130888 countsByYear W21471308882022 @default.
• W2147130888 countsByYear W21471308882023 @default.
• W2147130888 crossrefType "journal-article" @default.
• W2147130888 hasAuthorship W2147130888A5006020430 @default.
• W2147130888 hasAuthorship W2147130888A5062465955 @default.
• W2147130888 hasBestOaLocation W21471308881 @default.
• W2147130888 hasConcept C121332964 @default.
• W2147130888 hasConcept C12554922 @default.
• W2147130888 hasConcept C125705527 @default.
• W2147130888 hasConcept C14228908 @default.
• W2147130888 hasConcept C142669718 @default.
• W2147130888 hasConcept C1491633281 @default.
• W2147130888 hasConcept C178790620 @default.
• W2147130888 hasConcept C185592680 @default.
• W2147130888 hasConcept C192144188 @default.
• W2147130888 hasConcept C203253989 @default.
• W2147130888 hasConcept C2993400109 @default.
• W2147130888 hasConcept C44228677 @default.
• W2147130888 hasConcept C521977710 @default.
• W2147130888 hasConcept C53195969 @default.
• W2147130888 hasConcept C55493867 @default.
• W2147130888 hasConcept C59999672 @default.
• W2147130888 hasConcept C62520636 @default.
• W2147130888 hasConcept C86803240 @default.
• W2147130888 hasConcept C95444343 @default.
• W2147130888 hasConceptScore W2147130888C121332964 @default.
• W2147130888 hasConceptScore W2147130888C12554922 @default.
• W2147130888 hasConceptScore W2147130888C125705527 @default.
• W2147130888 hasConceptScore W2147130888C14228908 @default.
• W2147130888 hasConceptScore W2147130888C142669718 @default.
• W2147130888 hasConceptScore W2147130888C1491633281 @default.
• W2147130888 hasConceptScore W2147130888C178790620 @default.
• W2147130888 hasConceptScore W2147130888C185592680 @default.
• W2147130888 hasConceptScore W2147130888C192144188 @default.
• W2147130888 hasConceptScore W2147130888C203253989 @default.
• W2147130888 hasConceptScore W2147130888C2993400109 @default.
• W2147130888 hasConceptScore W2147130888C44228677 @default.
• W2147130888 hasConceptScore W2147130888C521977710 @default.
• W2147130888 hasConceptScore W2147130888C53195969 @default.
• W2147130888 hasConceptScore W2147130888C55493867 @default.
• W2147130888 hasConceptScore W2147130888C59999672 @default.
• W2147130888 hasConceptScore W2147130888C62520636 @default.
• W2147130888 hasConceptScore W2147130888C86803240 @default.

• next