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- W2147147762 abstract "Ramos-Baron 1 concluded an editorial on basic asthma research in this journal by affirming that, in science, asking the right questions is often harder and more important than finding the answers. It is hard to disagree with this statement but, if we reflect on childhood asthma in relation to the advances over the last couple of decades in terms of pathogenesis, pathophysiology, and diagnosis, and their therapeutic implications, we are in a somewhat similar situation to that of whoever wrote “when we found out the answers, they withdrew the questions.” This suggests that new questions should be sought to find suitable answers, 2,3 in this case for better management of childhood asthma, the goal of which is complete control of the disease. 4 The traditional approach was to equate (identify) asthma with atopy and eosinophilic inflammation, and to exclude from this definition other recurrent respiratory conditions that did not present such findings. However, the signs and symptoms seen in asthmatic children are common to other processes, a substantial component of which also respond to conventional asthma drugs, namely, inhaled corticosteroids. This has prompted us to extend the concept of asthma to include numerous obstructive diseases of the small airways, particularly in infants (infant asthma), although the subsequent disease course may be heterogenous. Early transient wheezing, persistent nonatopic wheezing, and atopic wheezing in infants represent 3 different childhood asthma phenotypes, 5 both in epidemiological terms 6 and in terms of function 7 and disease course. 8 In this heterogenous group of infants with recurrent wheezing or risk of asthma, response to conventional treatment with inhaled corticosteroids is not clear-cut. In general terms, these infants respond satisfactorily to the intervention itself, but the natural course of the disease is not modified, as confirmed in 3 recent clinical trials (PAC, 9 PEAK, 10 and IFWIN 11 studies) with different inclusion criteria and" @default.
- W2147147762 created "2016-06-24" @default.
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- W2147147762 date "2007-01-01" @default.
- W2147147762 modified "2023-10-18" @default.
- W2147147762 title "Childhood Asthma: Do the Answers Coincide With the Questions?" @default.
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- W2147147762 doi "https://doi.org/10.1016/s1579-2129(07)60149-9" @default.
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