Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147149546> ?p ?o ?g. }
- W2147149546 endingPage "1145" @default.
- W2147149546 startingPage "1137" @default.
- W2147149546 abstract "Destruction of self-tissue by unwanted inflammation is central to the pathology of numerous diseases and disorders. The inflammatory response consists of a series of events, involving several cell types and biological signalling molecules. Potassium (K+) channels are also involved in this process and may be potential therapeutic targets. Three of the most promising K+ channel drug targets are the KATP, Kv1.3 and BKCa channels and thus will be reviewed in this article. These channels affect diverse aspects of inflammation and its associated disorders. KATP channels protect tissue against ischaemia/reperfusion (I/R) injury, Kv1.3 channels regulate T-cell activation and BKCa channels play a role in controlling cellular activities triggered by depolarisation. KATP and BKCa channel openers and Kv1.3 channel blockers have all been shown experimentally to exert anti-inflammatory effects. However, their efficacy in the clinical setting remains to be determined. The most recent patents regarding the use of K+ channel modulators to ameliorate inflammation induced tissue damage will be discussed in light of previous work examining the role of these channels in the inflammatory response." @default.
- W2147149546 created "2016-06-24" @default.
- W2147149546 creator A5008717277 @default.
- W2147149546 date "2001-07-01" @default.
- W2147149546 modified "2023-09-27" @default.
- W2147149546 title "Potassium channel modulators as anti-inflammatory agents" @default.
- W2147149546 cites W1516227220 @default.
- W2147149546 cites W1519345480 @default.
- W2147149546 cites W1854945595 @default.
- W2147149546 cites W1967892892 @default.
- W2147149546 cites W1969282918 @default.
- W2147149546 cites W1969978734 @default.
- W2147149546 cites W1973227515 @default.
- W2147149546 cites W1975558014 @default.
- W2147149546 cites W1983218780 @default.
- W2147149546 cites W1987664769 @default.
- W2147149546 cites W1989125682 @default.
- W2147149546 cites W1990322544 @default.
- W2147149546 cites W1991006430 @default.
- W2147149546 cites W1999333036 @default.
- W2147149546 cites W2002483785 @default.
- W2147149546 cites W2009574988 @default.
- W2147149546 cites W2012462160 @default.
- W2147149546 cites W2014856276 @default.
- W2147149546 cites W2024185063 @default.
- W2147149546 cites W2024608183 @default.
- W2147149546 cites W2036209063 @default.
- W2147149546 cites W2036385659 @default.
- W2147149546 cites W2039958625 @default.
- W2147149546 cites W2046433412 @default.
- W2147149546 cites W2046712654 @default.
- W2147149546 cites W2046716112 @default.
- W2147149546 cites W2047353740 @default.
- W2147149546 cites W2050823731 @default.
- W2147149546 cites W2054133363 @default.
- W2147149546 cites W2062401160 @default.
- W2147149546 cites W2067071865 @default.
- W2147149546 cites W2075474730 @default.
- W2147149546 cites W2084977187 @default.
- W2147149546 cites W2097550685 @default.
- W2147149546 cites W2100405364 @default.
- W2147149546 cites W2108824149 @default.
- W2147149546 cites W2131974729 @default.
- W2147149546 cites W2137083867 @default.
- W2147149546 cites W2146217294 @default.
- W2147149546 cites W2149880033 @default.
- W2147149546 cites W2156593674 @default.
- W2147149546 cites W2158633534 @default.
- W2147149546 cites W2171573307 @default.
- W2147149546 cites W2339154093 @default.
- W2147149546 doi "https://doi.org/10.1517/13543776.11.7.1137" @default.
- W2147149546 hasPublicationYear "2001" @default.
- W2147149546 type Work @default.
- W2147149546 sameAs 2147149546 @default.
- W2147149546 citedByCount "4" @default.
- W2147149546 countsByYear W21471495462019 @default.
- W2147149546 countsByYear W21471495462020 @default.
- W2147149546 crossrefType "journal-article" @default.
- W2147149546 hasAuthorship W2147149546A5008717277 @default.
- W2147149546 hasConcept C126322002 @default.
- W2147149546 hasConcept C169760540 @default.
- W2147149546 hasConcept C185592680 @default.
- W2147149546 hasConcept C203014093 @default.
- W2147149546 hasConcept C2776914184 @default.
- W2147149546 hasConcept C2778457506 @default.
- W2147149546 hasConcept C4141045 @default.
- W2147149546 hasConcept C71924100 @default.
- W2147149546 hasConcept C83743174 @default.
- W2147149546 hasConcept C86803240 @default.
- W2147149546 hasConcept C98274493 @default.
- W2147149546 hasConceptScore W2147149546C126322002 @default.
- W2147149546 hasConceptScore W2147149546C169760540 @default.
- W2147149546 hasConceptScore W2147149546C185592680 @default.
- W2147149546 hasConceptScore W2147149546C203014093 @default.
- W2147149546 hasConceptScore W2147149546C2776914184 @default.
- W2147149546 hasConceptScore W2147149546C2778457506 @default.
- W2147149546 hasConceptScore W2147149546C4141045 @default.
- W2147149546 hasConceptScore W2147149546C71924100 @default.
- W2147149546 hasConceptScore W2147149546C83743174 @default.
- W2147149546 hasConceptScore W2147149546C86803240 @default.
- W2147149546 hasConceptScore W2147149546C98274493 @default.
- W2147149546 hasIssue "7" @default.
- W2147149546 hasLocation W21471495461 @default.
- W2147149546 hasOpenAccess W2147149546 @default.
- W2147149546 hasPrimaryLocation W21471495461 @default.
- W2147149546 hasRelatedWork W1506837922 @default.
- W2147149546 hasRelatedWork W1825111584 @default.
- W2147149546 hasRelatedWork W2003598888 @default.
- W2147149546 hasRelatedWork W2007520808 @default.
- W2147149546 hasRelatedWork W2011345948 @default.
- W2147149546 hasRelatedWork W2049643635 @default.
- W2147149546 hasRelatedWork W2085249878 @default.
- W2147149546 hasRelatedWork W2108333597 @default.
- W2147149546 hasRelatedWork W2201189018 @default.
- W2147149546 hasRelatedWork W4251999110 @default.
- W2147149546 hasVolume "11" @default.
- W2147149546 isParatext "false" @default.
- W2147149546 isRetracted "false" @default.