FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147149882> ?p ?o ?g. }

• W2147149882 endingPage "32" @default.
• W2147149882 startingPage "11" @default.
• W2147149882 abstract "Several enzymes that were originally characterized to have one defined function in intermediatory metabolism are now shown to participate in a number of other cellular processes. Multifunctional proteins may be crucial for building of the highly complex networks that maintain the function and structure in the eukaryotic cell possessing a relatively low number of protein-encoding genes. One facet of this phenomenon, on which I will focus in this review, is the interaction of metabolic enzymes with RNA. The list of such enzymes known to be associated with RNA is constantly expanding, but the most intriguing question remains unanswered: are the metabolic enzyme-RNA interactions relevant in the regulation of cell metabolism? It has been proposed that metabolic RNA-binding enzymes participate in general regulatory circuits linking a metabolic function to a regulatory mechanism, similar to the situation of the metabolic enzyme aconitase, which also functions as iron-responsive RNA-binding regulatory element. However, some authors have cautioned that some of such enzymes may merely represent molecular fossils of the transition from an RNA to a protein world and that the RNA-binding properties may not have a functional significance. Here I will describe enzymes that have been shown to interact with RNA (in several cases a newly discovered RNA-binding protein has been identified as a well-known metabolic enzyme) and particularly point out those whose ability to interact with RNA seems to have a proven physiological significance. I will also try to depict the molecular switch between an enzyme's metabolic and regulatory functions in cases where such a mechanism has been elucidated. For most of these enzymes relations between their enzymatic functions and RNA metabolism are unclear or seem not to exist. All these enzymes are ancient, as judged by their wide distribution, and participate in fundamental biochemical pathways." @default.
• W2147149882 created "2016-06-24" @default.
• W2147149882 creator A5062072359 @default.
• W2147149882 date "2006-01-12" @default.
• W2147149882 modified "2023-10-12" @default.
• W2147149882 title "Metabolic enzymes that bind RNA: yet another level of cellular regulatory network?" @default.
• W2147149882 cites W105838460 @default.
• W2147149882 cites W1127888983 @default.
• W2147149882 cites W122080432 @default.
• W2147149882 cites W138209033 @default.
• W2147149882 cites W1480540532 @default.
• W2147149882 cites W149801576 @default.
• W2147149882 cites W1500978251 @default.
• W2147149882 cites W1501735810 @default.
• W2147149882 cites W1514067978 @default.
• W2147149882 cites W1516205541 @default.
• W2147149882 cites W1530519259 @default.
• W2147149882 cites W1535475592 @default.
• W2147149882 cites W1540176830 @default.
• W2147149882 cites W1540415460 @default.
• W2147149882 cites W1547848353 @default.
• W2147149882 cites W1551862901 @default.
• W2147149882 cites W1572589552 @default.
• W2147149882 cites W1575376210 @default.
• W2147149882 cites W1576283072 @default.
• W2147149882 cites W1581740874 @default.
• W2147149882 cites W1588641521 @default.
• W2147149882 cites W1592356287 @default.
• W2147149882 cites W1595702727 @default.
• W2147149882 cites W1596380237 @default.
• W2147149882 cites W1599435087 @default.
• W2147149882 cites W1648909091 @default.
• W2147149882 cites W1673653510 @default.
• W2147149882 cites W1676741499 @default.
• W2147149882 cites W1848146283 @default.
• W2147149882 cites W1883812525 @default.
• W2147149882 cites W1915447707 @default.
• W2147149882 cites W1943372705 @default.
• W2147149882 cites W1965759870 @default.
• W2147149882 cites W1966429662 @default.
• W2147149882 cites W1968558643 @default.
• W2147149882 cites W1969484981 @default.
• W2147149882 cites W1969825843 @default.
• W2147149882 cites W1970726343 @default.
• W2147149882 cites W1971082648 @default.
• W2147149882 cites W1971099877 @default.
• W2147149882 cites W1972221158 @default.
• W2147149882 cites W1973945485 @default.
• W2147149882 cites W1976055256 @default.
• W2147149882 cites W1976085354 @default.
• W2147149882 cites W1977577386 @default.
• W2147149882 cites W1981527579 @default.
• W2147149882 cites W1983706728 @default.
• W2147149882 cites W1988694194 @default.
• W2147149882 cites W1989215365 @default.
• W2147149882 cites W1989544026 @default.
• W2147149882 cites W1991612185 @default.
• W2147149882 cites W1994119394 @default.
• W2147149882 cites W1995284123 @default.
• W2147149882 cites W1996380626 @default.
• W2147149882 cites W1997777936 @default.
• W2147149882 cites W2001840412 @default.
• W2147149882 cites W2001863162 @default.
• W2147149882 cites W2003235764 @default.
• W2147149882 cites W2003600929 @default.
• W2147149882 cites W2006110932 @default.
• W2147149882 cites W2006391153 @default.
• W2147149882 cites W2006417813 @default.
• W2147149882 cites W2006756269 @default.
• W2147149882 cites W2007744451 @default.
• W2147149882 cites W2008000048 @default.
• W2147149882 cites W2010787777 @default.
• W2147149882 cites W2011574434 @default.
• W2147149882 cites W2011877182 @default.
• W2147149882 cites W2012565545 @default.
• W2147149882 cites W2012670550 @default.
• W2147149882 cites W2012962528 @default.
• W2147149882 cites W2013060968 @default.
• W2147149882 cites W2013439046 @default.
• W2147149882 cites W2014453292 @default.
• W2147149882 cites W2015629167 @default.
• W2147149882 cites W2015631023 @default.
• W2147149882 cites W2016211620 @default.
• W2147149882 cites W2017302711 @default.
• W2147149882 cites W2017369170 @default.
• W2147149882 cites W2017541340 @default.
• W2147149882 cites W2017800571 @default.
• W2147149882 cites W2017905322 @default.
• W2147149882 cites W2018366596 @default.
• W2147149882 cites W2018948641 @default.
• W2147149882 cites W2019922918 @default.
• W2147149882 cites W2022162825 @default.
• W2147149882 cites W2025196468 @default.
• W2147149882 cites W2026556168 @default.
• W2147149882 cites W2026789634 @default.
• W2147149882 cites W2026902356 @default.
• W2147149882 cites W2027156422 @default.
• W2147149882 cites W2027442509 @default.

• next