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• W2147151936 abstract "To investigate the effect of opiates on human immunodeficiency virus type 1 (HIV-1)-related neuronal apoptosis, primary human fetal neuronal/glial cell cultures were exposed to gp120(IIIB) in the absence and the presence of morphine. Although morphine by itself had little effect on neuronal survival, the combination of morphine (>/=10(-7) mol/L) and gp120(IIIB) (1 nmol/L) significantly increased neuronal apoptosis. The mechanism whereby morphine potentiates gp120(IIIB)-induced neuronal apoptosis appears to involve activation of the p38 mitogen-activated protein kinase intracellular signaling pathway and microglial cells dispersed within the neuronal/glial cell cultures. These results provide additional insight into the molecular basis whereby opiate abuse could promote HIV-1-associated dementia." @default.
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• W2147151936 date "2005-03-15" @default.
• W2147151936 modified "2023-10-07" @default.
• W2147151936 title "Morphine Potentiates HIV‐1 gp120–Induced Neuronal Apoptosis" @default.
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• W2147151936 doi "https://doi.org/10.1086/427830" @default.
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