FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147169794> ?p ?o ?g. }

• W2147169794 endingPage "6261" @default.
• W2147169794 startingPage "6256" @default.
• W2147169794 abstract "A combined forward and reverse genetic approach was undertaken to test the candidacy of IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor for systemic lupus erythematosus (SLE). In studying approximately 5,000 subjects and healthy controls, 5 SNPs spanning the IRAK1 gene showed disease association (P values reaching 10(-10), odds ratio >1.5) in both adult- and childhood-onset SLE, in 4 different ethnic groups, with a 4 SNP haplotype (GGGG) being strongly associated with the disease. The functional role of IRAK1 was next examined by using congenic mouse models bearing the disease loci: Sle1 or Sle3. IRAK1 deficiency abrogated all lupus-associated phenotypes, including IgM and IgG autoantibodies, lymphocytic activation, and renal disease in both models. In addition, the absence of IRAK1 reversed the dendritic cell hyperactivity associated with Sle3. Collectively, the forward genetic studies in human SLE and the mechanistic studies in mouse models establish IRAK1 as a disease gene in lupus, capable of modulating at least 2 key checkpoints in disease development. This demonstration of an X chromosome gene as a disease susceptibility factor in human SLE raises the possibility that the gender difference in SLE may in part be attributed to sex chromosome genes." @default.
• W2147169794 created "2016-06-24" @default.
• W2147169794 creator A5000728225 @default.
• W2147169794 creator A5002980083 @default.
• W2147169794 creator A5007862965 @default.
• W2147169794 creator A5010072602 @default.
• W2147169794 creator A5014962817 @default.
• W2147169794 creator A5015249906 @default.
• W2147169794 creator A5025774056 @default.
• W2147169794 creator A5028394360 @default.
• W2147169794 creator A5030650722 @default.
• W2147169794 creator A5032199338 @default.
• W2147169794 creator A5038569452 @default.
• W2147169794 creator A5041270389 @default.
• W2147169794 creator A5042585597 @default.
• W2147169794 creator A5047679905 @default.
• W2147169794 creator A5050920027 @default.
• W2147169794 creator A5051736959 @default.
• W2147169794 creator A5052053321 @default.
• W2147169794 creator A5053013933 @default.
• W2147169794 creator A5056255167 @default.
• W2147169794 creator A5057881013 @default.
• W2147169794 creator A5061226924 @default.
• W2147169794 creator A5062742878 @default.
• W2147169794 creator A5066335093 @default.
• W2147169794 creator A5068498766 @default.
• W2147169794 creator A5072603878 @default.
• W2147169794 creator A5082041460 @default.
• W2147169794 creator A5082669927 @default.
• W2147169794 creator A5088258614 @default.
• W2147169794 creator A5090500376 @default.
• W2147169794 date "2009-04-14" @default.
• W2147169794 modified "2023-10-16" @default.
• W2147169794 title "Identification of<i>IRAK1</i>as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus" @default.
• W2147169794 cites W1549853453 @default.
• W2147169794 cites W1562508597 @default.
• W2147169794 cites W166442226 @default.
• W2147169794 cites W1964895626 @default.
• W2147169794 cites W1970195004 @default.
• W2147169794 cites W1975891070 @default.
• W2147169794 cites W1977835740 @default.
• W2147169794 cites W1991500494 @default.
• W2147169794 cites W1996626475 @default.
• W2147169794 cites W2014688976 @default.
• W2147169794 cites W2018412076 @default.
• W2147169794 cites W2026255377 @default.
• W2147169794 cites W2026441976 @default.
• W2147169794 cites W2040459416 @default.
• W2147169794 cites W2061446718 @default.
• W2147169794 cites W2063819412 @default.
• W2147169794 cites W2070527591 @default.
• W2147169794 cites W2071889908 @default.
• W2147169794 cites W2072687150 @default.
• W2147169794 cites W2073527744 @default.
• W2147169794 cites W2074292775 @default.
• W2147169794 cites W2088449391 @default.
• W2147169794 cites W2100706488 @default.
• W2147169794 cites W2111483667 @default.
• W2147169794 cites W2157752701 @default.
• W2147169794 cites W2160344319 @default.
• W2147169794 cites W2161633633 @default.
• W2147169794 cites W2162530578 @default.
• W2147169794 cites W2163889822 @default.
• W2147169794 cites W2166907718 @default.
• W2147169794 cites W2168781986 @default.
• W2147169794 cites W4313335875 @default.
• W2147169794 cites W54413410 @default.
• W2147169794 doi "https://doi.org/10.1073/pnas.0901181106" @default.
• W2147169794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2669395" @default.
• W2147169794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19329491" @default.
• W2147169794 hasPublicationYear "2009" @default.
• W2147169794 type Work @default.
• W2147169794 sameAs 2147169794 @default.
• W2147169794 citedByCount "231" @default.
• W2147169794 countsByYear W21471697942012 @default.
• W2147169794 countsByYear W21471697942013 @default.
• W2147169794 countsByYear W21471697942014 @default.
• W2147169794 countsByYear W21471697942015 @default.
• W2147169794 countsByYear W21471697942016 @default.
• W2147169794 countsByYear W21471697942017 @default.
• W2147169794 countsByYear W21471697942018 @default.
• W2147169794 countsByYear W21471697942019 @default.
• W2147169794 countsByYear W21471697942020 @default.
• W2147169794 countsByYear W21471697942021 @default.
• W2147169794 countsByYear W21471697942022 @default.
• W2147169794 countsByYear W21471697942023 @default.
• W2147169794 crossrefType "journal-article" @default.
• W2147169794 hasAuthorship W2147169794A5000728225 @default.
• W2147169794 hasAuthorship W2147169794A5002980083 @default.
• W2147169794 hasAuthorship W2147169794A5007862965 @default.
• W2147169794 hasAuthorship W2147169794A5010072602 @default.
• W2147169794 hasAuthorship W2147169794A5014962817 @default.
• W2147169794 hasAuthorship W2147169794A5015249906 @default.
• W2147169794 hasAuthorship W2147169794A5025774056 @default.
• W2147169794 hasAuthorship W2147169794A5028394360 @default.
• W2147169794 hasAuthorship W2147169794A5030650722 @default.
• W2147169794 hasAuthorship W2147169794A5032199338 @default.
• W2147169794 hasAuthorship W2147169794A5038569452 @default.

• next