Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147175052> ?p ?o ?g. }
- W2147175052 abstract "Vibrio parahaemolyticus elicits gastroenteritis by deploying Type III Secretion Systems (TTSS) to deliver effector proteins into epithelial cells of the human intestinal tract. The bacteria must adhere to the human cells to allow colonization and operation of the TTSS translocation apparatus bridging the bacterium and the host cell. This article first reviews recent advances in identifying the molecules responsible for intercellular adherence. V. parahaemolyticus possesses two TTSS, each of which delivers an exclusive set of effectors and mediates unique effects on the host cell. TTSS effectors primarily target and alter the activation status of host cell signalling proteins, thereby bringing about changes in the regulation of cellular behaviour. TTSS1 is responsible for the cytotoxicity of V. parahaemolyticus, while TTSS2 is necessary for the enterotoxicity of the pathogen. Recent publications have elucidated the function of several TTSS effectors and their importance in the virulence of the bacterium. This review will explore the ability of the TTSS to manipulate activities of human intestinal cells and how this modification of cell function favours bacterial colonization and persistence of V. parahaemolyticus in the host." @default.
- W2147175052 created "2016-06-24" @default.
- W2147175052 creator A5061596451 @default.
- W2147175052 creator A5081183956 @default.
- W2147175052 date "2014-01-01" @default.
- W2147175052 modified "2023-10-17" @default.
- W2147175052 title "Manipulation of intestinal epithelial cell function by the cell contact-dependent type III secretion systems of Vibrio parahaemolyticus" @default.
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