Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147187810> ?p ?o ?g. }
- W2147187810 endingPage "197" @default.
- W2147187810 startingPage "182" @default.
- W2147187810 abstract "The increasing prevalence, variable pathogenesis, progressive natural history, and complications of type 2 diabetes emphasise the urgent need for new treatment strategies. Longacting (eg, once weekly) agonists of the glucagon-like-peptide-1 receptor are advanced in development, and they improve prandial insulin secretion, reduce excess glucagon production, and promote satiety. Trials of inhibitors of dipeptidyl peptidase 4, which enhance the effect of endogenous incretin hormones, are also nearing completion. Novel approaches to glycaemic regulation include use of inhibitors of the sodium-glucose cotransporter 2, which increase renal glucose elimination, and inhibitors of 11β-hydroxysteroid dehydrogenase 1, which reduce the glucocorticoid effects in liver and fat. Insulin-releasing glucokinase activators and pancreatic-G-protein-coupled fatty-acid-receptor agonists, glucagon-receptor antagonists, and metabolic inhibitors of hepatic glucose output are being assessed. Early proof of principle has been shown for compounds that enhance and partly mimic insulin action and replicate some effects of bariatric surgery." @default.
- W2147187810 created "2016-06-24" @default.
- W2147187810 creator A5023295361 @default.
- W2147187810 creator A5031933657 @default.
- W2147187810 creator A5034383160 @default.
- W2147187810 creator A5090743194 @default.
- W2147187810 date "2011-07-01" @default.
- W2147187810 modified "2023-10-18" @default.
- W2147187810 title "Management of type 2 diabetes: new and future developments in treatment" @default.
- W2147187810 cites W1584646599 @default.
- W2147187810 cites W1963557257 @default.
- W2147187810 cites W1970632332 @default.
- W2147187810 cites W1974115114 @default.
- W2147187810 cites W1975591028 @default.
- W2147187810 cites W1976503602 @default.
- W2147187810 cites W1978262109 @default.
- W2147187810 cites W1980790007 @default.
- W2147187810 cites W1981012218 @default.
- W2147187810 cites W1983718158 @default.
- W2147187810 cites W1984386737 @default.
- W2147187810 cites W1985401769 @default.
- W2147187810 cites W1994636940 @default.
- W2147187810 cites W1997024473 @default.
- W2147187810 cites W1997746154 @default.
- W2147187810 cites W1998369233 @default.
- W2147187810 cites W1999133358 @default.
- W2147187810 cites W1999414774 @default.
- W2147187810 cites W2002834562 @default.
- W2147187810 cites W2004576836 @default.
- W2147187810 cites W2005082727 @default.
- W2147187810 cites W2005230264 @default.
- W2147187810 cites W2008954563 @default.
- W2147187810 cites W2009510103 @default.
- W2147187810 cites W2013195172 @default.
- W2147187810 cites W2013481385 @default.
- W2147187810 cites W2021809976 @default.
- W2147187810 cites W2024529821 @default.
- W2147187810 cites W2038034590 @default.
- W2147187810 cites W2038961236 @default.
- W2147187810 cites W2039647212 @default.
- W2147187810 cites W2040943060 @default.
- W2147187810 cites W2044867170 @default.
- W2147187810 cites W2046188044 @default.
- W2147187810 cites W2050899637 @default.
- W2147187810 cites W2058675165 @default.
- W2147187810 cites W2059245135 @default.
- W2147187810 cites W2061865937 @default.
- W2147187810 cites W2064119981 @default.
- W2147187810 cites W2065319712 @default.
- W2147187810 cites W2069711307 @default.
- W2147187810 cites W2074014927 @default.
- W2147187810 cites W2074142099 @default.
- W2147187810 cites W2074734623 @default.
- W2147187810 cites W2075073089 @default.
- W2147187810 cites W2077372959 @default.
- W2147187810 cites W2079370062 @default.
- W2147187810 cites W2080228357 @default.
- W2147187810 cites W2081276121 @default.
- W2147187810 cites W2081614914 @default.
- W2147187810 cites W2082746738 @default.
- W2147187810 cites W2082982247 @default.
- W2147187810 cites W2084948079 @default.
- W2147187810 cites W2085073123 @default.
- W2147187810 cites W2086033777 @default.
- W2147187810 cites W2090898804 @default.
- W2147187810 cites W2092136583 @default.
- W2147187810 cites W2093587125 @default.
- W2147187810 cites W2093774827 @default.
- W2147187810 cites W2096773810 @default.
- W2147187810 cites W2097176029 @default.
- W2147187810 cites W2097543219 @default.
- W2147187810 cites W2097722989 @default.
- W2147187810 cites W2097784879 @default.
- W2147187810 cites W2104359225 @default.
- W2147187810 cites W2104401221 @default.
- W2147187810 cites W2104479115 @default.
- W2147187810 cites W2104742442 @default.
- W2147187810 cites W2105656265 @default.
- W2147187810 cites W2105812875 @default.
- W2147187810 cites W2106036385 @default.
- W2147187810 cites W2106154942 @default.
- W2147187810 cites W2109536283 @default.
- W2147187810 cites W2109728760 @default.
- W2147187810 cites W2110058008 @default.
- W2147187810 cites W2110791445 @default.
- W2147187810 cites W2114041992 @default.
- W2147187810 cites W2114276479 @default.
- W2147187810 cites W2115926243 @default.
- W2147187810 cites W2117637280 @default.
- W2147187810 cites W2118186702 @default.
- W2147187810 cites W2120312841 @default.
- W2147187810 cites W2122077393 @default.
- W2147187810 cites W2122188063 @default.
- W2147187810 cites W2122551774 @default.
- W2147187810 cites W2127125241 @default.
- W2147187810 cites W2127167047 @default.
- W2147187810 cites W2127833912 @default.
- W2147187810 cites W2129934471 @default.