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- W2147199361 abstract "AIM: The present study was aimed to evaluate the antioxidant property of Hemidesmus indicus (L.) R. Br.var. pubescens (W. & A.) Hk.f. leaf, by in vivo methods.METHODS: The protective effect of methanol extract of H. indicus var. pubescens leaves (at doses 200, 400 and 600 mg/kg) on CCl4 induced hepatotoxicity was studied in albino Wistar rats and the effects were compared with that of standard antioxidant silymarin. The parameters evaluated were hepatic levels of superoxide dismutase, catalase, peroxidase, reduced glutathione, total proteins and malondialdehyde (MDA).RESULTS: All three doses exhibited significant increase in the levels of SOD, peroxidase and a significant decrease in lipid peroxidation; reduced glutathione and catalase levels were significantly increased only with 600mg/kg dose of the extract.CONCLUSIONS: The study revealed that leaf of H. indicus var. pubescens possesses equipotent antioxidant effects with the standard antioxidant silymarin. Further work is required to isolate and evaluate the active principle(s) and elucidate the exact mechanism of action." @default.
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- W2147199361 date "2011-01-01" @default.
- W2147199361 modified "2023-09-24" @default.
- W2147199361 title "Antioxidant activity of leaf of <i>Hemidesmus indicus</i> (L.) R. Br. var. <i>pubescens</i> (W. A.) Hk.f. (Periplocaceae)- an in vivo analysis" @default.
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- W2147199361 doi "https://doi.org/10.5455/spatula.20110524114752" @default.
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