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• W2147200956 abstract "textabstractHematopoiesis is the process of formation of new blood cells.1 During embryonic development,the process starts in the yolk sac, in so called blood islands. As development of theembryo progresses, blood cell formation continues predominantly in the liver, and afterbirth the bone marrow takes over the process of hematopoiesis.New blood cells continuously need to be generated throughout life, as the majority of matureblood cells have a limited life-span. In a healthy adult, this results in the estimated productionof approximately 1010 new blood cells per hour.1 All different types of mature bloodcells originate from a pool of self-renewing hematopoietic stem cells (HSC’s) that residesin the bone marrow. In a strictly regulated process, the multipotent HSC’s can differentiateinto either a common myeloid or common lymphoid progenitor cells (Figure 1). While thelymphoid progenitor cells will differentiate and mature into either B-lymphocytes, T-lymphocytes,or natural killer cells, the myeloid progenitor cells will give rise to the other whiteblood cells (leukocytes) such as granulocytes (i.e. neutrophils, basophils and eosinophils),monocytes/macrophages and mast cells, but also to the red blood cells (erythrocytes) andthe platelets (thrombocytes)." @default.
• W2147200956 created "2016-06-24" @default.
• W2147200956 creator A5032463262 @default.
• W2147200956 date "2011-11-16" @default.
• W2147200956 modified "2023-09-28" @default.
• W2147200956 title "Molecular Genetic Insights in Cytogenetically-Normal Pediatric Acute Myeloid Leukemia" @default.
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