Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147207812> ?p ?o ?g. }
- W2147207812 endingPage "5582" @default.
- W2147207812 startingPage "5574" @default.
- W2147207812 abstract "The liver tolerance effect has been attributed to a unique potential of liver-resident nonprofessional APCs including hepatocytes (HCs) to suppress T cell responses. The exact molecular mechanism of T cell suppression by liver APCs is still largely unknown. In mice, IL-10-dependent T cell suppression is observed after Th1-mediated hepatitis induced by Con A. In this study, we show that HCs, particularly those from regenerating livers of Con A-pretreated mice, induced a regulatory phenotype in naive CD4(+) T cells in vitro. Using reporter mice, we observed that these T regulatory cells released substantial amounts of IL-10, produced IFN-γ, failed to express Foxp3, but suppressed proliferation of responder T cells upon restimulation with anti-CD3 mAb. Hence, these regulatory cells feature a similar phenotype as the recently described IL-10-producing Th1 cells, which are generated upon activation of Notch signaling. Indeed, inhibition of γ-secretase and a disintegrin and metalloproteinase 17 but not a disintegrin and metalloproteinase 10, respectively, which blocked Notch activation, prevented IL-10 secretion. HCs from Con A-pretreated mice showed enhanced expression of the Notch ligand Jagged1 and significantly increased receptor density of Notch1 on CD4(+) T cells. However, HCs from Con A-pretreated IFN regulatory factor 1(-/-) mice, which cannot respond to IFN-γ, as well as those from IFN-γ(-/-) mice failed to augment IL-10 production by CD4(+) T cells. In conclusion, it seems that HCs fine-tune liver inflammation by upregulation of Jagged1 and activation of Notch signaling in Th1 cells. This mechanism might be of particular importance in the regenerating liver subsequent to Th1-mediated hepatitis." @default.
- W2147207812 created "2016-06-24" @default.
- W2147207812 creator A5005787669 @default.
- W2147207812 creator A5006634561 @default.
- W2147207812 creator A5011261251 @default.
- W2147207812 creator A5019214841 @default.
- W2147207812 creator A5026441514 @default.
- W2147207812 creator A5038146893 @default.
- W2147207812 creator A5040160488 @default.
- W2147207812 creator A5048928035 @default.
- W2147207812 creator A5065372486 @default.
- W2147207812 creator A5089057275 @default.
- W2147207812 creator A5091016746 @default.
- W2147207812 date "2013-10-18" @default.
- W2147207812 modified "2023-10-14" @default.
- W2147207812 title "Hepatocytes Contribute to Immune Regulation in the Liver by Activation of the Notch Signaling Pathway in T Cells" @default.
- W2147207812 cites W1498929362 @default.
- W2147207812 cites W1506645874 @default.
- W2147207812 cites W1509909867 @default.
- W2147207812 cites W1575083490 @default.
- W2147207812 cites W1964156956 @default.
- W2147207812 cites W1965696997 @default.
- W2147207812 cites W1966731849 @default.
- W2147207812 cites W1968627142 @default.
- W2147207812 cites W1971890973 @default.
- W2147207812 cites W1973323884 @default.
- W2147207812 cites W1974781378 @default.
- W2147207812 cites W1984475127 @default.
- W2147207812 cites W1985761442 @default.
- W2147207812 cites W1986337007 @default.
- W2147207812 cites W1987116953 @default.
- W2147207812 cites W1989105929 @default.
- W2147207812 cites W1994262539 @default.
- W2147207812 cites W2004071897 @default.
- W2147207812 cites W2015898002 @default.
- W2147207812 cites W2019215354 @default.
- W2147207812 cites W2026647673 @default.
- W2147207812 cites W2034890422 @default.
- W2147207812 cites W2038661420 @default.
- W2147207812 cites W2042005033 @default.
- W2147207812 cites W2054973241 @default.
- W2147207812 cites W2056716376 @default.
- W2147207812 cites W2064707212 @default.
- W2147207812 cites W2069220094 @default.
- W2147207812 cites W2074576643 @default.
- W2147207812 cites W2075816687 @default.
- W2147207812 cites W2087257930 @default.
- W2147207812 cites W2088985230 @default.
- W2147207812 cites W2090427489 @default.
- W2147207812 cites W2095804489 @default.
- W2147207812 cites W2098320221 @default.
- W2147207812 cites W2121100040 @default.
- W2147207812 cites W2121209580 @default.
- W2147207812 cites W2124621398 @default.
- W2147207812 cites W2130487791 @default.
- W2147207812 cites W2136097155 @default.
- W2147207812 cites W2145738273 @default.
- W2147207812 cites W2148300725 @default.
- W2147207812 cites W2152404236 @default.
- W2147207812 cites W2162819001 @default.
- W2147207812 cites W57402234 @default.
- W2147207812 doi "https://doi.org/10.4049/jimmunol.1300826" @default.
- W2147207812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24140644" @default.
- W2147207812 hasPublicationYear "2013" @default.
- W2147207812 type Work @default.
- W2147207812 sameAs 2147207812 @default.
- W2147207812 citedByCount "46" @default.
- W2147207812 countsByYear W21472078122014 @default.
- W2147207812 countsByYear W21472078122015 @default.
- W2147207812 countsByYear W21472078122016 @default.
- W2147207812 countsByYear W21472078122017 @default.
- W2147207812 countsByYear W21472078122018 @default.
- W2147207812 countsByYear W21472078122019 @default.
- W2147207812 countsByYear W21472078122020 @default.
- W2147207812 countsByYear W21472078122021 @default.
- W2147207812 countsByYear W21472078122022 @default.
- W2147207812 countsByYear W21472078122023 @default.
- W2147207812 crossrefType "journal-article" @default.
- W2147207812 hasAuthorship W2147207812A5005787669 @default.
- W2147207812 hasAuthorship W2147207812A5006634561 @default.
- W2147207812 hasAuthorship W2147207812A5011261251 @default.
- W2147207812 hasAuthorship W2147207812A5019214841 @default.
- W2147207812 hasAuthorship W2147207812A5026441514 @default.
- W2147207812 hasAuthorship W2147207812A5038146893 @default.
- W2147207812 hasAuthorship W2147207812A5040160488 @default.
- W2147207812 hasAuthorship W2147207812A5048928035 @default.
- W2147207812 hasAuthorship W2147207812A5065372486 @default.
- W2147207812 hasAuthorship W2147207812A5089057275 @default.
- W2147207812 hasAuthorship W2147207812A5091016746 @default.
- W2147207812 hasBestOaLocation W21472078121 @default.
- W2147207812 hasConcept C104317684 @default.
- W2147207812 hasConcept C127561419 @default.
- W2147207812 hasConcept C161879069 @default.
- W2147207812 hasConcept C185592680 @default.
- W2147207812 hasConcept C203014093 @default.
- W2147207812 hasConcept C2776090121 @default.
- W2147207812 hasConcept C2776914184 @default.
- W2147207812 hasConcept C2779727006 @default.