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- W2147221623 abstract "Hepatitis B virus (HBV) variants with amino acid mutations in the a epitope of the major surface protein have been identified, and questions have been raised regarding their biologic properties. Dilutions of serum that contained the first such describedHBVmutant, with an Arg-for-Glysubstitution at codon 145 of the S gene, were inoculated into 6 seronegative chimpanzees. Five of the animals developed serologicand/or biochemical evidence of hepatitis B. A polymerase chain reaction-based assay that discriminated between the wild type and mutant viral genomes revealed that a pure population of the mutant genome was present in the 10−6 and 10−7 dilutions of the index serum, resulting in infection of the chimpanzees receiving these dilutions only with the mutant virus. A clone of the mutant virus replicated normally following transfection in vitro. Thus, this HBV surface gene mutant is viable, infectious, and pathogenic in chimpanzees." @default.
- W2147221623 created "2016-06-24" @default.
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- W2147221623 date "1997-03-01" @default.
- W2147221623 modified "2023-10-14" @default.
- W2147221623 title "Infectivity and Pathogenicity in Chimpanzees of a Surface Gene Mutant of Hepatitis B Virus that Emerged in a Vaccinated Infant" @default.
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- W2147221623 doi "https://doi.org/10.1093/infdis/175.3.511" @default.
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