FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147249280> ?p ?o ?g. }

• W2147249280 endingPage "3015" @default.
• W2147249280 startingPage "3006" @default.
• W2147249280 abstract "Visceral glomerular epithelial cells (GEC) are critical for normal permselectivity of the kidney. Nephrin is a molecule that is expressed specifically in GEC in a structure called the slit diaphragm and is required for normal morphology and permselectivity of GEC. However, the mechanisms of action of nephrin are not understood precisely. The intracellular domain of nephrin has six conserved tyrosine residues. It was hypothesized that these tyrosine residues are phosphorylated by Src-family kinases and that this phosphorylation modulates the function of nephrin. A transient transfection system was used to study the role of tyrosine phosphorylation of the cytoplasmic domain of nephrin in its function. When nephrin was co-transfected with Src-family kinases Fyn or Src in Cos-1 cells, nephrin was strongly tyrosine phosphorylated by Fyn and less so by Src. The results with tyrosine-to-phenylalanine mutations suggested that multiple tyrosine residues contribute to phosphorylation mediated by Src-family kinases. The intracellular domain of nephrin is known to interact with another slit diaphragm protein, podocin. When nephrin and podocin were transfected with Fyn, the interaction between nephrin and podocin was augmented significantly. Podocin was not tyrosine phosphorylated by Fyn; thus, the increased interaction is likely to be secondary to tyrosine phosphorylation of nephrin. Fyn also significantly augmented the activation of the AP-1 promoter induced by nephrin and podocin. In summary, Fyn phosphorylates the cytoplasmic domain of nephrin on tyrosine, leading to enhanced association with podocin and downstream signaling of nephrin." @default.
• W2147249280 created "2016-06-24" @default.
• W2147249280 creator A5024023421 @default.
• W2147249280 creator A5035050685 @default.
• W2147249280 creator A5057301328 @default.
• W2147249280 creator A5057779986 @default.
• W2147249280 creator A5087742625 @default.
• W2147249280 date "2004-12-01" @default.
• W2147249280 modified "2023-10-08" @default.
• W2147249280 title "Src-Family Kinase Fyn Phosphorylates the Cytoplasmic Domain of Nephrin and Modulates Its Interaction with Podocin" @default.
• W2147249280 cites W1565536510 @default.
• W2147249280 cites W1573317982 @default.
• W2147249280 cites W1887837461 @default.
• W2147249280 cites W1972845034 @default.
• W2147249280 cites W1993961434 @default.
• W2147249280 cites W2014154395 @default.
• W2147249280 cites W2019286212 @default.
• W2147249280 cites W2024431713 @default.
• W2147249280 cites W2038163496 @default.
• W2147249280 cites W2052675962 @default.
• W2147249280 cites W2062271737 @default.
• W2147249280 cites W2070193928 @default.
• W2147249280 cites W2093862824 @default.
• W2147249280 cites W2099365070 @default.
• W2147249280 cites W2101257013 @default.
• W2147249280 cites W2110230080 @default.
• W2147249280 cites W2114889093 @default.
• W2147249280 cites W2121977177 @default.
• W2147249280 cites W2129416468 @default.
• W2147249280 cites W2131252883 @default.
• W2147249280 cites W2133992677 @default.
• W2147249280 cites W2134983755 @default.
• W2147249280 cites W2135679847 @default.
• W2147249280 cites W2161873278 @default.
• W2147249280 cites W2165581077 @default.
• W2147249280 cites W2168517908 @default.
• W2147249280 cites W2411336130 @default.
• W2147249280 cites W53296430 @default.
• W2147249280 doi "https://doi.org/10.1097/01.asn.0000146689.88078.80" @default.
• W2147249280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15579503" @default.
• W2147249280 hasPublicationYear "2004" @default.
• W2147249280 type Work @default.
• W2147249280 sameAs 2147249280 @default.
• W2147249280 citedByCount "136" @default.
• W2147249280 countsByYear W21472492802012 @default.
• W2147249280 countsByYear W21472492802013 @default.
• W2147249280 countsByYear W21472492802014 @default.
• W2147249280 countsByYear W21472492802015 @default.
• W2147249280 countsByYear W21472492802016 @default.
• W2147249280 countsByYear W21472492802017 @default.
• W2147249280 countsByYear W21472492802018 @default.
• W2147249280 countsByYear W21472492802019 @default.
• W2147249280 countsByYear W21472492802020 @default.
• W2147249280 countsByYear W21472492802021 @default.
• W2147249280 countsByYear W21472492802022 @default.
• W2147249280 crossrefType "journal-article" @default.
• W2147249280 hasAuthorship W2147249280A5024023421 @default.
• W2147249280 hasAuthorship W2147249280A5035050685 @default.
• W2147249280 hasAuthorship W2147249280A5057301328 @default.
• W2147249280 hasAuthorship W2147249280A5057779986 @default.
• W2147249280 hasAuthorship W2147249280A5087742625 @default.
• W2147249280 hasBestOaLocation W21472492801 @default.
• W2147249280 hasConcept C108636557 @default.
• W2147249280 hasConcept C11960822 @default.
• W2147249280 hasConcept C134018914 @default.
• W2147249280 hasConcept C185592680 @default.
• W2147249280 hasConcept C197153747 @default.
• W2147249280 hasConcept C2776165026 @default.
• W2147249280 hasConcept C2776855237 @default.
• W2147249280 hasConcept C2777146197 @default.
• W2147249280 hasConcept C2777553839 @default.
• W2147249280 hasConcept C2779561371 @default.
• W2147249280 hasConcept C2780091579 @default.
• W2147249280 hasConcept C2780819817 @default.
• W2147249280 hasConcept C3018201436 @default.
• W2147249280 hasConcept C37686147 @default.
• W2147249280 hasConcept C42362537 @default.
• W2147249280 hasConcept C502942594 @default.
• W2147249280 hasConcept C55493867 @default.
• W2147249280 hasConcept C62478195 @default.
• W2147249280 hasConcept C86803240 @default.
• W2147249280 hasConcept C95444343 @default.
• W2147249280 hasConceptScore W2147249280C108636557 @default.
• W2147249280 hasConceptScore W2147249280C11960822 @default.
• W2147249280 hasConceptScore W2147249280C134018914 @default.
• W2147249280 hasConceptScore W2147249280C185592680 @default.
• W2147249280 hasConceptScore W2147249280C197153747 @default.
• W2147249280 hasConceptScore W2147249280C2776165026 @default.
• W2147249280 hasConceptScore W2147249280C2776855237 @default.
• W2147249280 hasConceptScore W2147249280C2777146197 @default.
• W2147249280 hasConceptScore W2147249280C2777553839 @default.
• W2147249280 hasConceptScore W2147249280C2779561371 @default.
• W2147249280 hasConceptScore W2147249280C2780091579 @default.
• W2147249280 hasConceptScore W2147249280C2780819817 @default.
• W2147249280 hasConceptScore W2147249280C3018201436 @default.
• W2147249280 hasConceptScore W2147249280C37686147 @default.
• W2147249280 hasConceptScore W2147249280C42362537 @default.
• W2147249280 hasConceptScore W2147249280C502942594 @default.

• next