Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147249379> ?p ?o ?g. }
- W2147249379 endingPage "e00233" @default.
- W2147249379 startingPage "e00233" @default.
- W2147249379 abstract "The Valsalva maneuver (VM) produces large and abrupt increases in mean arterial pressure (MAP) at the onset of strain (Phase I), however, hypotension, sufficient to induce syncope, occurs upon VM release (phase III). We examined the effect of VM intensity and duration on middle cerebral artery blood velocity (MCAv) responses. Healthy men (n = 10; mean ± SD: 26 ± 4 years) completed 30%, 60%, and 90% of their maximal VM mouth pressure, for 5 and 10 sec (order randomized) while standing. Beat-to-beat MCAv and MAP during phase I (peak), at nadir (phase III), and recovery are reported as the change from standing baseline. During phase I, MCAv rose 15 ± 6 cm·s−1 (P < 0.001), which was not reliably different between intensities (P = 0.11), despite graded increases in MAP (P < 0.001; e.g., +12 ± 9 mmHg vs. +35 ± 14 for 5 sec 30% and 90% VM, respectively). During Phase III, the MCAv response was duration- (P = 0.045) and intensity dependent (P < 0.001), with the largest decrease observed following the 90% VM (e.g., −19 ± 13 and −15 ± 11 cm·s−1 for 5 and 10 sec VM, respectively) with a concomitant decrease in MAP (P < 0.001, −23 ± 11 and −23 ± 9 mmHg). This asymmetric response may be attributable to the differential modulators of MCAv throughout the VM. The mechanical effects of the elevated intrathoracic pressure during phase I may restrain increases in cerebral perfusion via related increases in intracranial pressure; however, during phase III the decrease in MCAv arises from an abrupt hypotension, the extent of which is dependent upon both the duration and intensity of the VM." @default.
- W2147249379 created "2016-06-24" @default.
- W2147249379 creator A5026966406 @default.
- W2147249379 creator A5052093082 @default.
- W2147249379 creator A5059435889 @default.
- W2147249379 creator A5077474283 @default.
- W2147249379 creator A5084812288 @default.
- W2147249379 date "2014-02-01" @default.
- W2147249379 modified "2023-10-16" @default.
- W2147249379 title "The cerebrovascular response to graded Valsalva maneuvers while standing" @default.
- W2147249379 cites W1565894869 @default.
- W2147249379 cites W1582532974 @default.
- W2147249379 cites W1852307386 @default.
- W2147249379 cites W1966071826 @default.
- W2147249379 cites W1966355383 @default.
- W2147249379 cites W1967961674 @default.
- W2147249379 cites W1984509277 @default.
- W2147249379 cites W1986772215 @default.
- W2147249379 cites W1987990823 @default.
- W2147249379 cites W1993057582 @default.
- W2147249379 cites W2004149336 @default.
- W2147249379 cites W2006840981 @default.
- W2147249379 cites W2028869710 @default.
- W2147249379 cites W2032656032 @default.
- W2147249379 cites W2040679672 @default.
- W2147249379 cites W2042622458 @default.
- W2147249379 cites W2043938462 @default.
- W2147249379 cites W2044310549 @default.
- W2147249379 cites W2047431474 @default.
- W2147249379 cites W2096365100 @default.
- W2147249379 cites W2099592577 @default.
- W2147249379 cites W2101077152 @default.
- W2147249379 cites W2102282914 @default.
- W2147249379 cites W2107075065 @default.
- W2147249379 cites W2114919659 @default.
- W2147249379 cites W2121903024 @default.
- W2147249379 cites W2121934251 @default.
- W2147249379 cites W2135541716 @default.
- W2147249379 cites W2136078346 @default.
- W2147249379 cites W2144553814 @default.
- W2147249379 cites W2156579478 @default.
- W2147249379 cites W2159631883 @default.
- W2147249379 cites W2161790639 @default.
- W2147249379 cites W2163498887 @default.
- W2147249379 cites W2166769055 @default.
- W2147249379 cites W2175159617 @default.
- W2147249379 cites W2260591796 @default.
- W2147249379 cites W2337655483 @default.
- W2147249379 cites W2341223505 @default.
- W2147249379 doi "https://doi.org/10.1002/phy2.233" @default.
- W2147249379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3966248" @default.
- W2147249379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24744902" @default.
- W2147249379 hasPublicationYear "2014" @default.
- W2147249379 type Work @default.
- W2147249379 sameAs 2147249379 @default.
- W2147249379 citedByCount "13" @default.
- W2147249379 countsByYear W21472493792014 @default.
- W2147249379 countsByYear W21472493792015 @default.
- W2147249379 countsByYear W21472493792016 @default.
- W2147249379 countsByYear W21472493792017 @default.
- W2147249379 countsByYear W21472493792018 @default.
- W2147249379 countsByYear W21472493792020 @default.
- W2147249379 countsByYear W21472493792022 @default.
- W2147249379 crossrefType "journal-article" @default.
- W2147249379 hasAuthorship W2147249379A5026966406 @default.
- W2147249379 hasAuthorship W2147249379A5052093082 @default.
- W2147249379 hasAuthorship W2147249379A5059435889 @default.
- W2147249379 hasAuthorship W2147249379A5077474283 @default.
- W2147249379 hasAuthorship W2147249379A5084812288 @default.
- W2147249379 hasBestOaLocation W21472493791 @default.
- W2147249379 hasConcept C126322002 @default.
- W2147249379 hasConcept C146957229 @default.
- W2147249379 hasConcept C164705383 @default.
- W2147249379 hasConcept C2775841333 @default.
- W2147249379 hasConcept C2776452961 @default.
- W2147249379 hasConcept C2777953023 @default.
- W2147249379 hasConcept C42219234 @default.
- W2147249379 hasConcept C541997718 @default.
- W2147249379 hasConcept C71924100 @default.
- W2147249379 hasConcept C84393581 @default.
- W2147249379 hasConceptScore W2147249379C126322002 @default.
- W2147249379 hasConceptScore W2147249379C146957229 @default.
- W2147249379 hasConceptScore W2147249379C164705383 @default.
- W2147249379 hasConceptScore W2147249379C2775841333 @default.
- W2147249379 hasConceptScore W2147249379C2776452961 @default.
- W2147249379 hasConceptScore W2147249379C2777953023 @default.
- W2147249379 hasConceptScore W2147249379C42219234 @default.
- W2147249379 hasConceptScore W2147249379C541997718 @default.
- W2147249379 hasConceptScore W2147249379C71924100 @default.
- W2147249379 hasConceptScore W2147249379C84393581 @default.
- W2147249379 hasIssue "2" @default.
- W2147249379 hasLocation W21472493791 @default.
- W2147249379 hasLocation W21472493792 @default.
- W2147249379 hasLocation W21472493793 @default.
- W2147249379 hasLocation W21472493794 @default.
- W2147249379 hasOpenAccess W2147249379 @default.
- W2147249379 hasPrimaryLocation W21472493791 @default.
- W2147249379 hasRelatedWork W1667504103 @default.