Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147251978> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2147251978 endingPage "359" @default.
- W2147251978 startingPage "352" @default.
- W2147251978 abstract "Summary-level longitudinal data on the clinical efficacy of drugs for rheumatoid arthritis (RA) are available in the literature. This information can be used to optimize the clinical development of new drugs for RA. The aim of this study was twofold: first, to quantify the time course of the ACR20 score across approved drugs and patient populations, and second, to apply this knowledge in the decision-making process for a specific compound, canakinumab. The integrated analysis included data from 37 phase II–III studies describing 13,474 patients. It showed that, with the tested doses/regimens of canakinumab, there was only a low probability that this drug would be better than the most effective current treatments. This finding supported the decision not to continue with clinical development of canakinumab in RA. This paper presents the first longitudinal model-based meta-analysis of ACR20. The framework can be applied to any other compound targeting RA, thereby supporting internal and external decision making at all clinical development stages. Clinical Pharmacology & Therapeutics (2012); 92 3, 352–359. doi:10.1038/clpt.2012.69" @default.
- W2147251978 created "2016-06-24" @default.
- W2147251978 creator A5016028680 @default.
- W2147251978 creator A5048890354 @default.
- W2147251978 creator A5060396305 @default.
- W2147251978 creator A5065075350 @default.
- W2147251978 creator A5072841901 @default.
- W2147251978 date "2012-07-04" @default.
- W2147251978 modified "2023-09-23" @default.
- W2147251978 title "Longitudinal Model-Based Meta-Analysis in Rheumatoid Arthritis: An Application Toward Model-Based Drug Development" @default.
- W2147251978 cites W1517555081 @default.
- W2147251978 cites W1972359429 @default.
- W2147251978 cites W1975404751 @default.
- W2147251978 cites W1980731415 @default.
- W2147251978 cites W2006566716 @default.
- W2147251978 cites W2007567206 @default.
- W2147251978 cites W2031210704 @default.
- W2147251978 cites W2067121689 @default.
- W2147251978 cites W2079359234 @default.
- W2147251978 cites W2097341637 @default.
- W2147251978 cites W2122152368 @default.
- W2147251978 cites W2133556574 @default.
- W2147251978 cites W2159106700 @default.
- W2147251978 cites W2166204514 @default.
- W2147251978 doi "https://doi.org/10.1038/clpt.2012.69" @default.
- W2147251978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22760002" @default.
- W2147251978 hasPublicationYear "2012" @default.
- W2147251978 type Work @default.
- W2147251978 sameAs 2147251978 @default.
- W2147251978 citedByCount "43" @default.
- W2147251978 countsByYear W21472519782012 @default.
- W2147251978 countsByYear W21472519782013 @default.
- W2147251978 countsByYear W21472519782014 @default.
- W2147251978 countsByYear W21472519782015 @default.
- W2147251978 countsByYear W21472519782016 @default.
- W2147251978 countsByYear W21472519782017 @default.
- W2147251978 countsByYear W21472519782018 @default.
- W2147251978 countsByYear W21472519782019 @default.
- W2147251978 countsByYear W21472519782020 @default.
- W2147251978 countsByYear W21472519782021 @default.
- W2147251978 countsByYear W21472519782022 @default.
- W2147251978 countsByYear W21472519782023 @default.
- W2147251978 crossrefType "journal-article" @default.
- W2147251978 hasAuthorship W2147251978A5016028680 @default.
- W2147251978 hasAuthorship W2147251978A5048890354 @default.
- W2147251978 hasAuthorship W2147251978A5060396305 @default.
- W2147251978 hasAuthorship W2147251978A5065075350 @default.
- W2147251978 hasAuthorship W2147251978A5072841901 @default.
- W2147251978 hasConcept C126322002 @default.
- W2147251978 hasConcept C177713679 @default.
- W2147251978 hasConcept C19527891 @default.
- W2147251978 hasConcept C2777575956 @default.
- W2147251978 hasConcept C2779134260 @default.
- W2147251978 hasConcept C2779725882 @default.
- W2147251978 hasConcept C2780035454 @default.
- W2147251978 hasConcept C2781228260 @default.
- W2147251978 hasConcept C535046627 @default.
- W2147251978 hasConcept C63433958 @default.
- W2147251978 hasConcept C64903051 @default.
- W2147251978 hasConcept C71924100 @default.
- W2147251978 hasConcept C98274493 @default.
- W2147251978 hasConceptScore W2147251978C126322002 @default.
- W2147251978 hasConceptScore W2147251978C177713679 @default.
- W2147251978 hasConceptScore W2147251978C19527891 @default.
- W2147251978 hasConceptScore W2147251978C2777575956 @default.
- W2147251978 hasConceptScore W2147251978C2779134260 @default.
- W2147251978 hasConceptScore W2147251978C2779725882 @default.
- W2147251978 hasConceptScore W2147251978C2780035454 @default.
- W2147251978 hasConceptScore W2147251978C2781228260 @default.
- W2147251978 hasConceptScore W2147251978C535046627 @default.
- W2147251978 hasConceptScore W2147251978C63433958 @default.
- W2147251978 hasConceptScore W2147251978C64903051 @default.
- W2147251978 hasConceptScore W2147251978C71924100 @default.
- W2147251978 hasConceptScore W2147251978C98274493 @default.
- W2147251978 hasIssue "3" @default.
- W2147251978 hasLocation W21472519781 @default.
- W2147251978 hasLocation W21472519782 @default.
- W2147251978 hasOpenAccess W2147251978 @default.
- W2147251978 hasPrimaryLocation W21472519781 @default.
- W2147251978 hasRelatedWork W1603416295 @default.
- W2147251978 hasRelatedWork W188266097 @default.
- W2147251978 hasRelatedWork W2080081537 @default.
- W2147251978 hasRelatedWork W2088663266 @default.
- W2147251978 hasRelatedWork W211573666 @default.
- W2147251978 hasRelatedWork W2329258414 @default.
- W2147251978 hasRelatedWork W2372770165 @default.
- W2147251978 hasRelatedWork W2566747388 @default.
- W2147251978 hasRelatedWork W3202735287 @default.
- W2147251978 hasRelatedWork W4206732464 @default.
- W2147251978 hasVolume "92" @default.
- W2147251978 isParatext "false" @default.
- W2147251978 isRetracted "false" @default.
- W2147251978 magId "2147251978" @default.
- W2147251978 workType "article" @default.