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• W2147258942 abstract "The basic helix-loop-helix (bHLH) eukaryotic transcription factors have the ability to form multiple dimer combinations. This property, together with limited DNA-binding specificity for the E box (CANNTG), makes them ideally suited for combinatorial control of gene expression. We tested the ability of all nine Saccharomyces cerevisiae bHLH proteins to regulate the enolase-encoding gene ENO1. ENO1 was known to be activated by the bHLH protein Sgc1p. Here we show that expression of an ENO1-lacZ reporter was also regulated by the other eight bHLH proteins, namely, Ino2p, Ino4p, Cbf1p, Rtg1p, Rtg3p, Pho4p, Hms1p, and Ygr290wp. ENO1-lacZ expression was also repressed by growth in inositol-choline-containing medium. Epistatic analysis and chromatin immunoprecipitation experiments showed that regulation by Sgc1p, Ino2p, Ino4p, and Cbf1p and repression by inositol-choline required three distal E boxes, E1, E2, and E3. The pattern of bHLH binding to the three E boxes and experiments with two dominant-negative mutant alleles of INO4 and INO2 support the model that bHLH dimer selection affects ENO1-lacZ expression. These results support the general model that bHLH proteins can coordinate different biological pathways via multiple mechanisms." @default.
• W2147258942 created "2016-06-24" @default.
• W2147258942 creator A5024845093 @default.
• W2147258942 creator A5028530805 @default.
• W2147258942 date "2007-05-01" @default.
• W2147258942 modified "2023-10-15" @default.
• W2147258942 title "Multiple Basic Helix-Loop-Helix Proteins Regulate Expression of the ENO1 Gene of Saccharomyces cerevisiae" @default.
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• W2147258942 doi "https://doi.org/10.1128/ec.00383-06" @default.
• W2147258942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1899243" @default.
• W2147258942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17351075" @default.
• W2147258942 hasPublicationYear "2007" @default.
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