FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147270292> ?p ?o ?g. }

• W2147270292 endingPage "178" @default.
• W2147270292 startingPage "177" @default.
• W2147270292 abstract "A 20-year-old obese man was referred to our hospital with 1-year hypertension and mild hypokalaemia (potassium, 3.3 mmol/l). The ratio of postcaptopril plasma aldosterone concentration (PAC) to plasma renin activity (PRA) was high [25.8 (ng/dl)/0.33 (ng/ml/h) = 77.4]. The PAC postsaline loading test remained high (28.1 ng/dl). The 24-h urinary catecholamines and VMA (vanillyl mandelic acid) were within normal limits. Primary aldosteronism was diagnosed, and a computed tomography disclosed an isodense mass with a maximal diameter of 4 cm over the right adrenal gland (Figure ​(Figure1).1). The patient then underwent right laparoscopic adrenalectomy. Grossly, a well-encapsulated 4.5 × 4.0 × 3.5 cm yellowish tumour with central necrosis was noted. Histologically, the tumour was composed of pleomorphic cells with high-grade nuclei, prominent nucleoli, and >1/3 of the tumour presenting patternless sheets of cells. Furthermore, the mitotic count was >5 in 50 high power fields with atypical mitotic figures (Figure ​(Figure2a2a and b). Adrenocortical carcinoma (ACC) was diagnosed according to the modified Weiss classification system [1]. Subsequent immunohistochemical studies confirmed that the tumour was aldosterone producing (Figure ​(Figure2c2c and d). Two months after the operation, PAC and PRA were 32.7 ng/dl and 25.45 ng/ml/h, respectively, and the patient became normotensive.Fig. 1Adrenal tumour. Non-contrast CT scan shows an oval tumour, 4 cm in diameter, in the right adrenal region.Fig. 2Histopathology of adrenocortical carcinoma. (a) Pleomorphic tumour cells form patternless sheets of cells. (b) Tumour cells with eosinophilic cytoplasm, high nuclear grade and atypical mitotic figures (arrows) (haematoxylin and eosin stain, 100×; ...ACCs are rare and account for an estimated 0.05–0.2% of all malignancies [2]. Hormonally functioning tumours occur in ∼50% of ACC patients. Nevertheless, the aldosterone-producing ACC are even rarer. There is a bimodal occurrence by age, with a peak incidence at 4 cm should raise clinical suspicion of adrenocortical malignancy, even at a young age." @default.
• W2147270292 created "2016-06-24" @default.
• W2147270292 creator A5010105028 @default.
• W2147270292 creator A5026131228 @default.
• W2147270292 creator A5032376286 @default.
• W2147270292 creator A5050677639 @default.
• W2147270292 creator A5072730535 @default.
• W2147270292 creator A5085605445 @default.
• W2147270292 date "2009-01-28" @default.
• W2147270292 modified "2023-09-27" @default.
• W2147270292 title "A rare cause of secondary hypertension" @default.
• W2147270292 cites W2006223990 @default.
• W2147270292 cites W2040642687 @default.
• W2147270292 cites W2319220638 @default.
• W2147270292 doi "https://doi.org/10.1093/ndtplus/sfn213" @default.
• W2147270292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4421360" @default.
• W2147270292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25949323" @default.
• W2147270292 hasPublicationYear "2009" @default.
• W2147270292 type Work @default.
• W2147270292 sameAs 2147270292 @default.
• W2147270292 citedByCount "2" @default.
• W2147270292 countsByYear W21472702922014 @default.
• W2147270292 countsByYear W21472702922019 @default.
• W2147270292 crossrefType "journal-article" @default.
• W2147270292 hasAuthorship W2147270292A5010105028 @default.
• W2147270292 hasAuthorship W2147270292A5026131228 @default.
• W2147270292 hasAuthorship W2147270292A5032376286 @default.
• W2147270292 hasAuthorship W2147270292A5050677639 @default.
• W2147270292 hasAuthorship W2147270292A5072730535 @default.
• W2147270292 hasAuthorship W2147270292A5085605445 @default.
• W2147270292 hasBestOaLocation W21472702921 @default.
• W2147270292 hasConcept C126322002 @default.
• W2147270292 hasConcept C2777581072 @default.
• W2147270292 hasConcept C71924100 @default.
• W2147270292 hasConcept C84393581 @default.
• W2147270292 hasConceptScore W2147270292C126322002 @default.
• W2147270292 hasConceptScore W2147270292C2777581072 @default.
• W2147270292 hasConceptScore W2147270292C71924100 @default.
• W2147270292 hasConceptScore W2147270292C84393581 @default.
• W2147270292 hasIssue "2" @default.
• W2147270292 hasLocation W21472702921 @default.
• W2147270292 hasLocation W21472702922 @default.
• W2147270292 hasLocation W21472702923 @default.
• W2147270292 hasLocation W21472702924 @default.
• W2147270292 hasOpenAccess W2147270292 @default.
• W2147270292 hasPrimaryLocation W21472702921 @default.
• W2147270292 hasRelatedWork W1506200166 @default.
• W2147270292 hasRelatedWork W1995515455 @default.
• W2147270292 hasRelatedWork W2039318446 @default.
• W2147270292 hasRelatedWork W2048182022 @default.
• W2147270292 hasRelatedWork W2080531066 @default.
• W2147270292 hasRelatedWork W2748952813 @default.
• W2147270292 hasRelatedWork W2899084033 @default.
• W2147270292 hasRelatedWork W3000489793 @default.
• W2147270292 hasRelatedWork W3032375762 @default.
• W2147270292 hasRelatedWork W3108674512 @default.
• W2147270292 hasVolume "2" @default.
• W2147270292 isParatext "false" @default.
• W2147270292 isRetracted "false" @default.
• W2147270292 magId "2147270292" @default.
• W2147270292 workType "article" @default.