Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147272885> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2147272885 endingPage "727" @default.
- W2147272885 startingPage "719" @default.
- W2147272885 abstract "Epoprostenol is a first-line therapy for patients with pulmonary arterial hypertension (PAH) in World Health Organization functional class IV who often have low cardiac output and hypotension. However, initiation of epoprostenol can cause hemodynamic collapse in these vulnerable patients. Inotropic agent support may prevent the hemodynamic instability caused by initiation of epoprostenol; however, a protocol for supportive therapy has not been established.To assess the reliability and prognostic effects of dobutamine and dopamine support at the initiation of epoprostenol therapy in patients with PAH.We initiated epoprostenol therapy in 71 patients with PAH. Hemodynamics at the initiation of epoprostenol were measured by right heart catheterization. We initiated dobutamine when a patient's mixed venous oxygen saturation was less than 60% or cardiac index was less than 2.0 L/min/m(2) or when right ventricular failure was clinically suspected. We initiated dopamine when a patient's systolic blood pressure was less than 90 mm Hg or urine volume was less than 20 ml/h.At the initiation of epoprostenol, dobutamine and/or dopamine were required to support 46 patients according to protocol. Eight patients died during the hospitalization and one patient received a living-donor lobar lung transplant after the initiation of epoprostenol therapy. Neither inotropic agent was an independent risk factor for short-term mortality (dobutamine: hazard ratio, 1.63; 95% confidence interval, 0.33-8.11; dopamine: hazard ratio, 0.22; 95% confidence interval, 0.03-1.70). Sixty-two patients were discharged for home infusion of epoprostenol. Transplant-free survival rates at 5 years were 80.0% for patients who did not require inotropic support at the start of epoprostenol and 76.6% for patients with who did require dopamine and/or dobutamine support (P = 0.45).Temporary use of dobutamine and dopamine appears to be safe for hemodynamic support at the initiation of epoprostenol therapy for selected patients with PAH with low cardiac output and hypotension. The protocol presented here requires validation at other centers." @default.
- W2147272885 created "2016-06-24" @default.
- W2147272885 creator A5023400259 @default.
- W2147272885 creator A5044544721 @default.
- W2147272885 creator A5048936597 @default.
- W2147272885 creator A5064721178 @default.
- W2147272885 creator A5068411660 @default.
- W2147272885 creator A5069940779 @default.
- W2147272885 date "2014-06-01" @default.
- W2147272885 modified "2023-09-27" @default.
- W2147272885 title "Catecholamine Support at the Initiation of Epoprostenol Therapy in Pulmonary Arterial Hypertension" @default.
- W2147272885 cites W1991638901 @default.
- W2147272885 cites W1994219663 @default.
- W2147272885 cites W2001017350 @default.
- W2147272885 cites W2003524712 @default.
- W2147272885 cites W2010087170 @default.
- W2147272885 cites W2021237750 @default.
- W2147272885 cites W2021363362 @default.
- W2147272885 cites W2023893179 @default.
- W2147272885 cites W2037502378 @default.
- W2147272885 cites W2046129904 @default.
- W2147272885 cites W2075630317 @default.
- W2147272885 cites W2079822517 @default.
- W2147272885 cites W2108168787 @default.
- W2147272885 cites W2113439927 @default.
- W2147272885 cites W2121032694 @default.
- W2147272885 cites W2136203952 @default.
- W2147272885 cites W2142743112 @default.
- W2147272885 cites W2155117262 @default.
- W2147272885 doi "https://doi.org/10.1513/annalsats.201308-268oc" @default.
- W2147272885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24716663" @default.
- W2147272885 hasPublicationYear "2014" @default.
- W2147272885 type Work @default.
- W2147272885 sameAs 2147272885 @default.
- W2147272885 citedByCount "9" @default.
- W2147272885 countsByYear W21472728852015 @default.
- W2147272885 countsByYear W21472728852017 @default.
- W2147272885 countsByYear W21472728852019 @default.
- W2147272885 countsByYear W21472728852022 @default.
- W2147272885 crossrefType "journal-article" @default.
- W2147272885 hasAuthorship W2147272885A5023400259 @default.
- W2147272885 hasAuthorship W2147272885A5044544721 @default.
- W2147272885 hasAuthorship W2147272885A5048936597 @default.
- W2147272885 hasAuthorship W2147272885A5064721178 @default.
- W2147272885 hasAuthorship W2147272885A5068411660 @default.
- W2147272885 hasAuthorship W2147272885A5069940779 @default.
- W2147272885 hasConcept C126322002 @default.
- W2147272885 hasConcept C139940330 @default.
- W2147272885 hasConcept C155710745 @default.
- W2147272885 hasConcept C164705383 @default.
- W2147272885 hasConcept C178853913 @default.
- W2147272885 hasConcept C207103383 @default.
- W2147272885 hasConcept C2777953023 @default.
- W2147272885 hasConcept C2778198053 @default.
- W2147272885 hasConcept C2780930700 @default.
- W2147272885 hasConcept C2781185063 @default.
- W2147272885 hasConcept C31861589 @default.
- W2147272885 hasConcept C35207712 @default.
- W2147272885 hasConcept C42219234 @default.
- W2147272885 hasConcept C44249647 @default.
- W2147272885 hasConcept C71924100 @default.
- W2147272885 hasConcept C84393581 @default.
- W2147272885 hasConceptScore W2147272885C126322002 @default.
- W2147272885 hasConceptScore W2147272885C139940330 @default.
- W2147272885 hasConceptScore W2147272885C155710745 @default.
- W2147272885 hasConceptScore W2147272885C164705383 @default.
- W2147272885 hasConceptScore W2147272885C178853913 @default.
- W2147272885 hasConceptScore W2147272885C207103383 @default.
- W2147272885 hasConceptScore W2147272885C2777953023 @default.
- W2147272885 hasConceptScore W2147272885C2778198053 @default.
- W2147272885 hasConceptScore W2147272885C2780930700 @default.
- W2147272885 hasConceptScore W2147272885C2781185063 @default.
- W2147272885 hasConceptScore W2147272885C31861589 @default.
- W2147272885 hasConceptScore W2147272885C35207712 @default.
- W2147272885 hasConceptScore W2147272885C42219234 @default.
- W2147272885 hasConceptScore W2147272885C44249647 @default.
- W2147272885 hasConceptScore W2147272885C71924100 @default.
- W2147272885 hasConceptScore W2147272885C84393581 @default.
- W2147272885 hasIssue "5" @default.
- W2147272885 hasLocation W21472728851 @default.
- W2147272885 hasLocation W21472728852 @default.
- W2147272885 hasOpenAccess W2147272885 @default.
- W2147272885 hasPrimaryLocation W21472728851 @default.
- W2147272885 hasRelatedWork W169204514 @default.
- W2147272885 hasRelatedWork W2045565486 @default.
- W2147272885 hasRelatedWork W2054298503 @default.
- W2147272885 hasRelatedWork W2082401116 @default.
- W2147272885 hasRelatedWork W2088254657 @default.
- W2147272885 hasRelatedWork W2258088479 @default.
- W2147272885 hasRelatedWork W2403704471 @default.
- W2147272885 hasRelatedWork W2413668657 @default.
- W2147272885 hasRelatedWork W2419750755 @default.
- W2147272885 hasRelatedWork W4293757447 @default.
- W2147272885 hasVolume "11" @default.
- W2147272885 isParatext "false" @default.
- W2147272885 isRetracted "false" @default.
- W2147272885 magId "2147272885" @default.
- W2147272885 workType "article" @default.