Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147279426> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2147279426 endingPage "389" @default.
- W2147279426 startingPage "377" @default.
- W2147279426 abstract "Inhibitors of carboxylesterases were used to determine the importance of enzymatic hydrolysis in the production of liver injury by esters of allyl alcohol. Hydrolysis of the esters allyl acetate, allyl cinnamate, and allyl phenoxyacetate by homogenates of liver from rats treated with 125 mg/kg triorthotolyl phosphate (TOTP) was almost completely inhibited compared to that of control livers. Allyl acetate, allyl cinnamate, and allyl phenoxyacetate were administered orally to rats 18 hr after pretreatment with 125 mg/kg TOTP or 0.5 to 10 mg/kg of the defoliant S,S,S-tributylphosphorotrithioate (DEF). TOTP pretreatment significantly inhibited the rise in plasma alanine-α-ketoglutarate transaminase (AKT) activity and prevented changes in liver morphology produced by 60 to 150 mg/kg allyl acetate. DEF pretreatment protected against the hepatotoxicity of 60 mg/kg allyl acetate. This protective effect was maximal after treatment with 1 mg/kg DEF, which inhibited liver esterase 56%. TOTP prevented the elevation of plasma AKT activity induced by 250, 400, or 600 mg/kg allyl cinnamate. TOTP exerted only a slight protective effect against allyl phenoxyacetate hepatic necrosis, in that it prevented the injury produced by 200 mg/kg but not that produced by 250 or 400 mg/kg allyl phenoxyacetate. Pretreatment of rats with 375 mg/kg pyrazole, an inhibitor of alcohol dehydrogenase, completely prevented the elevation of plasma AKT activity after 90 mg/kg allyl acetate or 250 mg/kg allyl cinnamate. These studies demonstrate that, while it is likely that all three allyl esters share a common mechanism of hepatotoxic action, enzymatic hydrolysis is a necessary step in the activation of allyl acetate and allyl cinnamate to hepatotoxins but is less important in the activation of allyl phenoxyacetate." @default.
- W2147279426 created "2016-06-24" @default.
- W2147279426 creator A5036042977 @default.
- W2147279426 creator A5052096534 @default.
- W2147279426 date "1978-08-01" @default.
- W2147279426 modified "2023-10-09" @default.
- W2147279426 title "Effect of carboxylesterase inhibitors on the acute hepatotoxicity of esters of allyl alcohol*1, *2" @default.
- W2147279426 cites W1938591059 @default.
- W2147279426 cites W1976680424 @default.
- W2147279426 cites W2021044205 @default.
- W2147279426 cites W2040387051 @default.
- W2147279426 cites W2053450369 @default.
- W2147279426 cites W2071625060 @default.
- W2147279426 cites W2090672985 @default.
- W2147279426 cites W2095410242 @default.
- W2147279426 cites W2212189306 @default.
- W2147279426 cites W2256405346 @default.
- W2147279426 cites W2268754477 @default.
- W2147279426 cites W2318756724 @default.
- W2147279426 cites W2318874590 @default.
- W2147279426 cites W2405214017 @default.
- W2147279426 cites W2413057338 @default.
- W2147279426 cites W3126716280 @default.
- W2147279426 doi "https://doi.org/10.1016/0041-008x(78)90102-3" @default.
- W2147279426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/705781" @default.
- W2147279426 hasPublicationYear "1978" @default.
- W2147279426 type Work @default.
- W2147279426 sameAs 2147279426 @default.
- W2147279426 citedByCount "27" @default.
- W2147279426 countsByYear W21472794262012 @default.
- W2147279426 countsByYear W21472794262013 @default.
- W2147279426 countsByYear W21472794262014 @default.
- W2147279426 countsByYear W21472794262016 @default.
- W2147279426 countsByYear W21472794262021 @default.
- W2147279426 countsByYear W21472794262022 @default.
- W2147279426 countsByYear W21472794262023 @default.
- W2147279426 crossrefType "journal-article" @default.
- W2147279426 hasAuthorship W2147279426A5036042977 @default.
- W2147279426 hasAuthorship W2147279426A5052096534 @default.
- W2147279426 hasConcept C161790260 @default.
- W2147279426 hasConcept C181199279 @default.
- W2147279426 hasConcept C185592680 @default.
- W2147279426 hasConcept C2776637226 @default.
- W2147279426 hasConcept C2777344606 @default.
- W2147279426 hasConcept C2778325069 @default.
- W2147279426 hasConcept C2779672685 @default.
- W2147279426 hasConcept C2781066024 @default.
- W2147279426 hasConcept C55493867 @default.
- W2147279426 hasConcept C86803240 @default.
- W2147279426 hasConcept C94412978 @default.
- W2147279426 hasConcept C98274493 @default.
- W2147279426 hasConceptScore W2147279426C161790260 @default.
- W2147279426 hasConceptScore W2147279426C181199279 @default.
- W2147279426 hasConceptScore W2147279426C185592680 @default.
- W2147279426 hasConceptScore W2147279426C2776637226 @default.
- W2147279426 hasConceptScore W2147279426C2777344606 @default.
- W2147279426 hasConceptScore W2147279426C2778325069 @default.
- W2147279426 hasConceptScore W2147279426C2779672685 @default.
- W2147279426 hasConceptScore W2147279426C2781066024 @default.
- W2147279426 hasConceptScore W2147279426C55493867 @default.
- W2147279426 hasConceptScore W2147279426C86803240 @default.
- W2147279426 hasConceptScore W2147279426C94412978 @default.
- W2147279426 hasConceptScore W2147279426C98274493 @default.
- W2147279426 hasIssue "2" @default.
- W2147279426 hasLocation W21472794261 @default.
- W2147279426 hasLocation W21472794262 @default.
- W2147279426 hasOpenAccess W2147279426 @default.
- W2147279426 hasPrimaryLocation W21472794261 @default.
- W2147279426 hasRelatedWork W2012446325 @default.
- W2147279426 hasRelatedWork W2031866561 @default.
- W2147279426 hasRelatedWork W2048018162 @default.
- W2147279426 hasRelatedWork W2061138506 @default.
- W2147279426 hasRelatedWork W2074052481 @default.
- W2147279426 hasRelatedWork W2088249402 @default.
- W2147279426 hasRelatedWork W2118357880 @default.
- W2147279426 hasRelatedWork W2380507668 @default.
- W2147279426 hasRelatedWork W2388882889 @default.
- W2147279426 hasRelatedWork W2412724792 @default.
- W2147279426 hasVolume "45" @default.
- W2147279426 isParatext "false" @default.
- W2147279426 isRetracted "false" @default.
- W2147279426 magId "2147279426" @default.
- W2147279426 workType "article" @default.