FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147284000> ?p ?o ?g. }

• W2147284000 endingPage "E102" @default.
• W2147284000 startingPage "E87" @default.
• W2147284000 abstract "It was reported previously that isolated human islets from individuals with type 2 diabetes mellitus (T2DM) show reduced glucose-stimulated insulin release. To assess the possibility that impaired bioenergetics may contribute to this defect, glucose-stimulated respiration (Vo(2)), glucose usage and oxidation, intracellular Ca(2+), and insulin secretion (IS) were measured in pancreatic islets isolated from three healthy and three type 2 diabetic organ donors. Isolated mouse and rat islets were studied for comparison. Islets were exposed to a staircase glucose stimulus, whereas IR and Vo(2) were measured. Vo(2) of human islets from normals and diabetics increased sigmoidally from equal baselines of 0.25 nmol/100 islets/min as a function of glucose concentration. Maximal Vo(2) of normal islets at 24 mM glucose was 0.40 ± 0.02 nmol·min(-1)·100 islets(-1), and the glucose S(0.5) was 4.39 ± 0.10 mM. The glucose stimulation of respiration of islets from diabetics was lower, V(max) of 0.32 ± 0.01 nmol·min(-1)·100 islets(-1), and the S(0.5) shifted to 5.43 ± 0.13 mM. Glucose-stimulated IS and the rise of intracellular Ca(2+) were also reduced in diabetic islets. A clinically effective glucokinase activator normalized the defective Vo(2), IR, and free calcium responses during glucose stimulation in islets from type 2 diabetics. The body of data shows that there is a clear relationship between the pancreatic islet energy (ATP) production rate and IS. This relationship was similar for normal human, mouse, and rat islets and the data for all species fitted a single sigmoidal curve. The shared threshold rate for IS was ∼13 pmol·min(-1)·islet(-1). Exendin-4, a GLP-1 analog, shifted the ATP production-IS curve to the left and greatly potentiated IS with an ATP production rate threshold of ∼10 pmol·min(-1)·islet(-1). Our data suggest that impaired β-cell bioenergetics resulting in greatly reduced ATP production is critical in the molecular pathogenesis of type 2 diabetes mellitus." @default.
• W2147284000 created "2016-06-24" @default.
• W2147284000 creator A5001074686 @default.
• W2147284000 creator A5033457901 @default.
• W2147284000 creator A5034021483 @default.
• W2147284000 creator A5039017686 @default.
• W2147284000 creator A5050182252 @default.
• W2147284000 creator A5054559935 @default.
• W2147284000 creator A5056119357 @default.
• W2147284000 creator A5068459012 @default.
• W2147284000 creator A5077901895 @default.
• W2147284000 creator A5084966112 @default.
• W2147284000 creator A5085663161 @default.
• W2147284000 creator A5085887181 @default.
• W2147284000 creator A5087837146 @default.
• W2147284000 creator A5091783433 @default.
• W2147284000 date "2012-01-01" @default.
• W2147284000 modified "2023-10-16" @default.
• W2147284000 title "Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics" @default.
• W2147284000 cites W102407095 @default.
• W2147284000 cites W119361254 @default.
• W2147284000 cites W1480222818 @default.
• W2147284000 cites W1492056314 @default.
• W2147284000 cites W1556984994 @default.
• W2147284000 cites W1582699060 @default.
• W2147284000 cites W1589981664 @default.
• W2147284000 cites W1699718277 @default.
• W2147284000 cites W1809874884 @default.
• W2147284000 cites W1966895543 @default.
• W2147284000 cites W1968368398 @default.
• W2147284000 cites W1969165259 @default.
• W2147284000 cites W1970431025 @default.
• W2147284000 cites W1970958676 @default.
• W2147284000 cites W1979689320 @default.
• W2147284000 cites W1982600501 @default.
• W2147284000 cites W1986946948 @default.
• W2147284000 cites W1990092556 @default.
• W2147284000 cites W1993378987 @default.
• W2147284000 cites W1994924615 @default.
• W2147284000 cites W2001827575 @default.
• W2147284000 cites W2002834562 @default.
• W2147284000 cites W2004014076 @default.
• W2147284000 cites W2012137033 @default.
• W2147284000 cites W2013481385 @default.
• W2147284000 cites W2013658326 @default.
• W2147284000 cites W2022228039 @default.
• W2147284000 cites W2037857580 @default.
• W2147284000 cites W2050605495 @default.
• W2147284000 cites W2055791664 @default.
• W2147284000 cites W2067674453 @default.
• W2147284000 cites W2067962261 @default.
• W2147284000 cites W2071189759 @default.
• W2147284000 cites W2076270562 @default.
• W2147284000 cites W2077032611 @default.
• W2147284000 cites W2081276121 @default.
• W2147284000 cites W2083850806 @default.
• W2147284000 cites W2089258801 @default.
• W2147284000 cites W2089569296 @default.
• W2147284000 cites W2090632954 @default.
• W2147284000 cites W2094177994 @default.
• W2147284000 cites W2094813557 @default.
• W2147284000 cites W2096773810 @default.
• W2147284000 cites W2100236190 @default.
• W2147284000 cites W2101359494 @default.
• W2147284000 cites W2104864428 @default.
• W2147284000 cites W2110015701 @default.
• W2147284000 cites W2112662561 @default.
• W2147284000 cites W2114124488 @default.
• W2147284000 cites W2126461698 @default.
• W2147284000 cites W2128167237 @default.
• W2147284000 cites W2130890592 @default.
• W2147284000 cites W2132557269 @default.
• W2147284000 cites W2137672956 @default.
• W2147284000 cites W2140255871 @default.
• W2147284000 cites W2141225315 @default.
• W2147284000 cites W2143840921 @default.
• W2147284000 cites W2148097161 @default.
• W2147284000 cites W2158213282 @default.
• W2147284000 cites W2159570963 @default.
• W2147284000 cites W2161641259 @default.
• W2147284000 cites W2164306929 @default.
• W2147284000 cites W2165796078 @default.
• W2147284000 cites W2166755525 @default.
• W2147284000 cites W2166949410 @default.
• W2147284000 cites W2169715407 @default.
• W2147284000 cites W2171224724 @default.
• W2147284000 cites W2171345965 @default.
• W2147284000 cites W2199557803 @default.
• W2147284000 cites W2218148748 @default.
• W2147284000 cites W2247538616 @default.
• W2147284000 cites W2292249586 @default.
• W2147284000 cites W2403578638 @default.
• W2147284000 cites W4241034232 @default.
• W2147284000 doi "https://doi.org/10.1152/ajpendo.00218.2011" @default.
• W2147284000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3328091" @default.
• W2147284000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21952036" @default.
• W2147284000 hasPublicationYear "2012" @default.
• W2147284000 type Work @default.

• next