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• W2147285276 abstract "Described is the synthesis of three different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90). Using fluorescence polarization anisotropy, we report the binding affinity of these fluorescein-labeled compounds to Hsp90 in its open state and ATP-dependent closed state. We show that the compounds demonstrate a conformation-dependent preference for binding to the closed state." @default.
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• W2147285276 date "2011-12-01" @default.
• W2147285276 modified "2023-09-26" @default.
• W2147285276 title "A small molecule that preferentially binds the closed conformation of Hsp90" @default.
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• W2147285276 doi "https://doi.org/10.1016/j.bmcl.2011.09.096" @default.
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