FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147295384> ?p ?o ?g. }

• W2147295384 endingPage "61" @default.
• W2147295384 startingPage "61" @default.
• W2147295384 abstract "Mechanical stresses are known to play important roles in atherosclerotic plaque initiation, progression and rupture. It has been well-accepted that atherosclerosis initiation and early progression correlate negatively with flow wall shear stresses (FSS). However, mechanisms governing advanced plaque progression are not well understood. In vivo serial MRI data (patient follow-up) were acquired from 14 patients after informed consent. Each patient had 2-4 scans (scan interval: 18 months). Thirty-two scan pairs (baseline and follow-up scans) were formed with slices matched for model construction and analysis. Each scan pair had 4-10 matched slices which gave 400-1000 data points for analysis (100 points per slice on lumen). Point-wise plaque progression was defined as the wall thickness increase (WTI) at each data point. 3D computational models with fluid-structure interactions were constructed based on in vivo serial MRI data to extract flow shear stress and plaque wall stress (PWS) on all data points to quantify correlations between plaque progression and mechanical stresses (FSS and PWS). FSS and PWS data corresponding to both maximum and minimum flow rates in a cardiac cycle were used to investigate the impact of flow rates on those correlations. Using follow-up scans and maximum flow rates, 19 out of 32 scan pairs showed a significant positive correlation between WTI and FSS (positive/negative/no significance correlation ratio = 19/9/4), and 26 out of 32 scan pairs showed a significant negative correlation between WTI and PWS (correlation ratio = 2/26/4). Corresponding to minimum flow rates, the correlation ratio for WTI vs. FSS and WTI vs. PWS were (20/7/5) and (2/26/4), respectively. Using baseline scans, the correlation ratios for WTI vs. FSS were (10/12/10) and (9/13/10) for maximum and minimum flow rates, respectively. The correlation ratios for WTI vs. PWS were the same (18/5/9), corresponding to maximum and minimum flow rates. Flow shear stress corresponding to the minimum flow rates in a cardiac cycle had slightly better correlation with WTI, compared to FSS corresponding to maximum flow rates. Choice of maximum or minimum flow rates had no impact on PWS correlations. Advanced plaque progression correlated positively with flow shear stress and negatively with plaque wall stress using follow-up scans. Correlation results using FSS at the baseline scan were inconclusive." @default.
• W2147295384 created "2016-06-24" @default.
• W2147295384 creator A5008769328 @default.
• W2147295384 creator A5014812404 @default.
• W2147295384 creator A5028936361 @default.
• W2147295384 creator A5033321028 @default.
• W2147295384 creator A5042360828 @default.
• W2147295384 creator A5083704908 @default.
• W2147295384 date "2011-01-01" @default.
• W2147295384 modified "2023-10-18" @default.
• W2147295384 title "Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress" @default.
• W2147295384 cites W1979098422 @default.
• W2147295384 cites W2027316849 @default.
• W2147295384 cites W2062747807 @default.
• W2147295384 cites W2065591461 @default.
• W2147295384 cites W2066233510 @default.
• W2147295384 cites W2069852059 @default.
• W2147295384 cites W2079466279 @default.
• W2147295384 cites W2082593218 @default.
• W2147295384 cites W2103398651 @default.
• W2147295384 cites W2134688511 @default.
• W2147295384 cites W2164365545 @default.
• W2147295384 cites W2396817 @default.
• W2147295384 doi "https://doi.org/10.1186/1475-925x-10-61" @default.
• W2147295384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3158559" @default.
• W2147295384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21771293" @default.
• W2147295384 hasPublicationYear "2011" @default.
• W2147295384 type Work @default.
• W2147295384 sameAs 2147295384 @default.
• W2147295384 citedByCount "5" @default.
• W2147295384 countsByYear W21472953842013 @default.
• W2147295384 countsByYear W21472953842014 @default.
• W2147295384 countsByYear W21472953842015 @default.
• W2147295384 countsByYear W21472953842023 @default.
• W2147295384 crossrefType "journal-article" @default.
• W2147295384 hasAuthorship W2147295384A5008769328 @default.
• W2147295384 hasAuthorship W2147295384A5014812404 @default.
• W2147295384 hasAuthorship W2147295384A5028936361 @default.
• W2147295384 hasAuthorship W2147295384A5033321028 @default.
• W2147295384 hasAuthorship W2147295384A5042360828 @default.
• W2147295384 hasAuthorship W2147295384A5083704908 @default.
• W2147295384 hasBestOaLocation W21472953841 @default.
• W2147295384 hasConcept C117220453 @default.
• W2147295384 hasConcept C126322002 @default.
• W2147295384 hasConcept C136229726 @default.
• W2147295384 hasConcept C159985019 @default.
• W2147295384 hasConcept C164705383 @default.
• W2147295384 hasConcept C192562407 @default.
• W2147295384 hasConcept C21141959 @default.
• W2147295384 hasConcept C2524010 @default.
• W2147295384 hasConcept C33923547 @default.
• W2147295384 hasConcept C71924100 @default.
• W2147295384 hasConcept C99398487 @default.
• W2147295384 hasConceptScore W2147295384C117220453 @default.
• W2147295384 hasConceptScore W2147295384C126322002 @default.
• W2147295384 hasConceptScore W2147295384C136229726 @default.
• W2147295384 hasConceptScore W2147295384C159985019 @default.
• W2147295384 hasConceptScore W2147295384C164705383 @default.
• W2147295384 hasConceptScore W2147295384C192562407 @default.
• W2147295384 hasConceptScore W2147295384C21141959 @default.
• W2147295384 hasConceptScore W2147295384C2524010 @default.
• W2147295384 hasConceptScore W2147295384C33923547 @default.
• W2147295384 hasConceptScore W2147295384C71924100 @default.
• W2147295384 hasConceptScore W2147295384C99398487 @default.
• W2147295384 hasIssue "1" @default.
• W2147295384 hasLocation W21472953841 @default.
• W2147295384 hasLocation W21472953842 @default.
• W2147295384 hasLocation W21472953843 @default.
• W2147295384 hasLocation W21472953844 @default.
• W2147295384 hasOpenAccess W2147295384 @default.
• W2147295384 hasPrimaryLocation W21472953841 @default.
• W2147295384 hasRelatedWork W2008851126 @default.
• W2147295384 hasRelatedWork W2011347913 @default.
• W2147295384 hasRelatedWork W2049397185 @default.
• W2147295384 hasRelatedWork W2073151595 @default.
• W2147295384 hasRelatedWork W2074833529 @default.
• W2147295384 hasRelatedWork W2125804349 @default.
• W2147295384 hasRelatedWork W2159512267 @default.
• W2147295384 hasRelatedWork W2304633692 @default.
• W2147295384 hasRelatedWork W2399063111 @default.
• W2147295384 hasRelatedWork W2899084033 @default.
• W2147295384 hasVolume "10" @default.
• W2147295384 isParatext "false" @default.
• W2147295384 isRetracted "false" @default.
• W2147295384 magId "2147295384" @default.
• W2147295384 workType "article" @default.