FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147313448> ?p ?o ?g. }

• W2147313448 endingPage "1917" @default.
• W2147313448 startingPage "1906" @default.
• W2147313448 abstract "Bio-equivalents (e.g., 17β-estradiol or dioxin equivalents) are commonly employed to quantify the in vitro effects of complex human or environmental samples. However, there is no generally accepted data analysis strategy for estimating and reporting bio-equivalents. Therefore, the aims of the present study are to 1) identify common mathematical models for the derivation of bio-equivalents from the literature, 2) assess the ability of those models to correctly predict bio-equivalents, and 3) propose measures to reduce uncertainty in their calculation and reporting. We compiled a database of 234 publications that report bio-equivalents. From the database, we extracted 3 data analysis strategies commonly used to estimate bio-equivalents. These models are based on linear or nonlinear interpolation, and the comparison of effect concentrations (ECX ). To assess their accuracy, we employed simulated data sets in different scenarios. The results indicate that all models lead to a considerable misestimation of bio-equivalents if certain mathematical assumptions (e.g., goodness of fit, parallelism of dose-response curves) are violated. However, nonlinear interpolation is most suitable to predict bio-equivalents from single-point estimates. Regardless of the model, subsequent linear extrapolation of bio-equivalents generates additional inaccuracy if the prerequisite of parallel dose-response curves is not met. When all these factors are taken into consideration, it becomes clear that data analysis introduces considerable uncertainty in the derived bio-equivalents. To improve accuracy and transparency of bio-equivalents, we propose a novel data analysis strategy and a checklist for reporting Minimum Information about Bio-equivalent ESTimates (MIBEST)." @default.
• W2147313448 created "2016-06-24" @default.
• W2147313448 creator A5020842159 @default.
• W2147313448 creator A5027504618 @default.
• W2147313448 creator A5030600667 @default.
• W2147313448 creator A5041175524 @default.
• W2147313448 creator A5042814978 @default.
• W2147313448 creator A5073739090 @default.
• W2147313448 date "2013-06-25" @default.
• W2147313448 modified "2023-10-06" @default.
• W2147313448 title "Deriving bio-equivalents from in vitro bioassays: Assessment of existing uncertainties and strategies to improve accuracy and reporting" @default.
• W2147313448 cites W1544923801 @default.
• W2147313448 cites W1592898544 @default.
• W2147313448 cites W1967554341 @default.
• W2147313448 cites W1972106025 @default.
• W2147313448 cites W1972152689 @default.
• W2147313448 cites W1973402545 @default.
• W2147313448 cites W1985163984 @default.
• W2147313448 cites W1999312152 @default.
• W2147313448 cites W2000469111 @default.
• W2147313448 cites W2004671794 @default.
• W2147313448 cites W2005567261 @default.
• W2147313448 cites W2007215874 @default.
• W2147313448 cites W2008470972 @default.
• W2147313448 cites W2010222646 @default.
• W2147313448 cites W2011582760 @default.
• W2147313448 cites W2013739759 @default.
• W2147313448 cites W2015048171 @default.
• W2147313448 cites W2017369919 @default.
• W2147313448 cites W2021752630 @default.
• W2147313448 cites W2022708239 @default.
• W2147313448 cites W2022948223 @default.
• W2147313448 cites W2025260655 @default.
• W2147313448 cites W2027575018 @default.
• W2147313448 cites W2029437336 @default.
• W2147313448 cites W2036551189 @default.
• W2147313448 cites W2038522804 @default.
• W2147313448 cites W2039051068 @default.
• W2147313448 cites W2040492212 @default.
• W2147313448 cites W2045029636 @default.
• W2147313448 cites W2045717408 @default.
• W2147313448 cites W2050554833 @default.
• W2147313448 cites W2053203387 @default.
• W2147313448 cites W2056379080 @default.
• W2147313448 cites W2057148580 @default.
• W2147313448 cites W2064323908 @default.
• W2147313448 cites W2067900804 @default.
• W2147313448 cites W2073876098 @default.
• W2147313448 cites W2080232534 @default.
• W2147313448 cites W2084004037 @default.
• W2147313448 cites W2095718513 @default.
• W2147313448 cites W2103299597 @default.
• W2147313448 cites W2108680369 @default.
• W2147313448 cites W2119099961 @default.
• W2147313448 cites W2121071389 @default.
• W2147313448 cites W2131977363 @default.
• W2147313448 cites W2139685584 @default.
• W2147313448 cites W2149189609 @default.
• W2147313448 cites W2151457406 @default.
• W2147313448 cites W2166856567 @default.
• W2147313448 cites W2167070287 @default.
• W2147313448 cites W2223822401 @default.
• W2147313448 doi "https://doi.org/10.1002/etc.2256" @default.
• W2147313448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23625661" @default.
• W2147313448 hasPublicationYear "2013" @default.
• W2147313448 type Work @default.
• W2147313448 sameAs 2147313448 @default.
• W2147313448 citedByCount "25" @default.
• W2147313448 countsByYear W21473134482013 @default.
• W2147313448 countsByYear W21473134482015 @default.
• W2147313448 countsByYear W21473134482016 @default.
• W2147313448 countsByYear W21473134482017 @default.
• W2147313448 countsByYear W21473134482018 @default.
• W2147313448 countsByYear W21473134482019 @default.
• W2147313448 countsByYear W21473134482020 @default.
• W2147313448 countsByYear W21473134482021 @default.
• W2147313448 countsByYear W21473134482022 @default.
• W2147313448 countsByYear W21473134482023 @default.
• W2147313448 crossrefType "journal-article" @default.
• W2147313448 hasAuthorship W2147313448A5020842159 @default.
• W2147313448 hasAuthorship W2147313448A5027504618 @default.
• W2147313448 hasAuthorship W2147313448A5030600667 @default.
• W2147313448 hasAuthorship W2147313448A5041175524 @default.
• W2147313448 hasAuthorship W2147313448A5042814978 @default.
• W2147313448 hasAuthorship W2147313448A5073739090 @default.
• W2147313448 hasConcept C104114177 @default.
• W2147313448 hasConcept C105795698 @default.
• W2147313448 hasConcept C124101348 @default.
• W2147313448 hasConcept C131857375 @default.
• W2147313448 hasConcept C132459708 @default.
• W2147313448 hasConcept C137800194 @default.
• W2147313448 hasConcept C154945302 @default.
• W2147313448 hasConcept C185592680 @default.
• W2147313448 hasConcept C33923547 @default.
• W2147313448 hasConcept C41008148 @default.
• W2147313448 hasConcept C55493867 @default.
• W2147313448 hasConceptScore W2147313448C104114177 @default.
• W2147313448 hasConceptScore W2147313448C105795698 @default.

• next