Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147317502> ?p ?o ?g. }
- W2147317502 endingPage "1475" @default.
- W2147317502 startingPage "1463" @default.
- W2147317502 abstract "The role of genetic factors has been hypothesized in the pathogenesis of a number of chronic inflammatory lung diseases. The genes of the major histocompatibility complex (MHC) locus on human chromosome 6 have been identified as important determinants in diseases caused both by inorganic and organic compounds such as beryllium, gold, acid anhydrides, isocyanates and grass pollens. Since many environmental factors are the determinants of the immunopathogenesis of asthma, pulmonary granulomatous disorders, hypersensitivity pneumonitis and fibrotic lung disorders, an understanding of the interaction between environmental factors is crucial to epidemiology, prevention and treatment of these disorders. Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts. A human leukocyte antigen class II marker (HLA-DP Glu69) has been found to be strongly associated with the disease. In in vitro studies, the gene has been shown to play a direct role in the immunopathogenesis of the disease. In human studies, the gene has been shown to confer increased susceptibility to beryllium in exposed workers, thus suggesting that HLA gene markers may be used as epidemiological probes to identify population groups at higher risk of environmental lung diseases, to identify environmental levels of lung immunotoxicants that would be safe for the entire population and to prevent disease risk associated with occupation, manufactured products and the environment. Studies on the associations between human leukocyte antigens and chronic inflammatory lung disorders are reviewed in the context of the berylliosis model." @default.
- W2147317502 created "2016-06-24" @default.
- W2147317502 creator A5000321654 @default.
- W2147317502 creator A5010690912 @default.
- W2147317502 creator A5019441565 @default.
- W2147317502 creator A5032263266 @default.
- W2147317502 creator A5043696677 @default.
- W2147317502 date "1998-12-01" @default.
- W2147317502 modified "2023-09-26" @default.
- W2147317502 title "Immunogenetic basis of environmental lung disease: lessons from the berylliosis model" @default.
- W2147317502 cites W148039946 @default.
- W2147317502 cites W1530234560 @default.
- W2147317502 cites W1591607269 @default.
- W2147317502 cites W1603122134 @default.
- W2147317502 cites W1812230610 @default.
- W2147317502 cites W1830456127 @default.
- W2147317502 cites W1842021509 @default.
- W2147317502 cites W1913737854 @default.
- W2147317502 cites W1922570445 @default.
- W2147317502 cites W1925788296 @default.
- W2147317502 cites W1953563746 @default.
- W2147317502 cites W1964364706 @default.
- W2147317502 cites W1966311044 @default.
- W2147317502 cites W1968234573 @default.
- W2147317502 cites W1968339417 @default.
- W2147317502 cites W1968408709 @default.
- W2147317502 cites W1968425675 @default.
- W2147317502 cites W1969622408 @default.
- W2147317502 cites W1975441789 @default.
- W2147317502 cites W1975939071 @default.
- W2147317502 cites W1976908748 @default.
- W2147317502 cites W1979528118 @default.
- W2147317502 cites W1980849339 @default.
- W2147317502 cites W1984509744 @default.
- W2147317502 cites W1986021950 @default.
- W2147317502 cites W1993343804 @default.
- W2147317502 cites W1994820490 @default.
- W2147317502 cites W1995976781 @default.
- W2147317502 cites W1997021233 @default.
- W2147317502 cites W1998761843 @default.
- W2147317502 cites W1998954170 @default.
- W2147317502 cites W2004919680 @default.
- W2147317502 cites W2005418895 @default.
- W2147317502 cites W2011220564 @default.
- W2147317502 cites W2011753513 @default.
- W2147317502 cites W2013487276 @default.
- W2147317502 cites W2014033568 @default.
- W2147317502 cites W2014051384 @default.
- W2147317502 cites W2015841533 @default.
- W2147317502 cites W2020345490 @default.
- W2147317502 cites W2020940152 @default.
- W2147317502 cites W2024543747 @default.
- W2147317502 cites W2026728536 @default.
- W2147317502 cites W2028367753 @default.
- W2147317502 cites W2031503626 @default.
- W2147317502 cites W2032470503 @default.
- W2147317502 cites W2034450203 @default.
- W2147317502 cites W2034530900 @default.
- W2147317502 cites W2035527847 @default.
- W2147317502 cites W2037950940 @default.
- W2147317502 cites W2038894107 @default.
- W2147317502 cites W2039748840 @default.
- W2147317502 cites W2040041671 @default.
- W2147317502 cites W2043053756 @default.
- W2147317502 cites W2045294108 @default.
- W2147317502 cites W2046553092 @default.
- W2147317502 cites W2052985308 @default.
- W2147317502 cites W2055185485 @default.
- W2147317502 cites W2055976862 @default.
- W2147317502 cites W2057144438 @default.
- W2147317502 cites W2058074749 @default.
- W2147317502 cites W2059324987 @default.
- W2147317502 cites W2062785119 @default.
- W2147317502 cites W2063381183 @default.
- W2147317502 cites W2063410606 @default.
- W2147317502 cites W2064157939 @default.
- W2147317502 cites W2072120170 @default.
- W2147317502 cites W2072447587 @default.
- W2147317502 cites W2074222872 @default.
- W2147317502 cites W2074444844 @default.
- W2147317502 cites W2074764005 @default.
- W2147317502 cites W2077122437 @default.
- W2147317502 cites W2077932793 @default.
- W2147317502 cites W2080490002 @default.
- W2147317502 cites W2080956086 @default.
- W2147317502 cites W2087698079 @default.
- W2147317502 cites W2088930672 @default.
- W2147317502 cites W2097641185 @default.
- W2147317502 cites W2100169779 @default.
- W2147317502 cites W2102726541 @default.
- W2147317502 cites W2108446467 @default.
- W2147317502 cites W2108710359 @default.
- W2147317502 cites W2114651938 @default.
- W2147317502 cites W2127795037 @default.
- W2147317502 cites W2130722817 @default.
- W2147317502 cites W2138037717 @default.
- W2147317502 cites W2139624980 @default.
- W2147317502 cites W2139757224 @default.