Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147322409> ?p ?o ?g. }
- W2147322409 endingPage "213" @default.
- W2147322409 startingPage "193" @default.
- W2147322409 abstract "Steroid hormone biosynthesis is acutely regulated by pituitary trophic hormones and other steroidogenic stimuli. This regulation requires the synthesis of a protein whose function is to translocate cholesterol from the outer to the inner mitochondrial membrane in steroidogenic cells, the rate-limiting step in steroid hormone formation. The steroidogenic acute regulatory (StAR) protein is an indispensable component in this process and is the best candidate to fill the role of the putative regulator. StAR is expressed in steroidogenic tissues in response to agents that stimulate steroid production, and mutations in the StAR gene result in the disease congenital lipoid adrenal hyperplasia, in which steroid hormone biosynthesis is severely compromised. The StAR null mouse has a phenotype that is essentially identical to the human disease. The positive and negative expression of StAR is sensitive to agents that increase and inhibit steroid biosynthesis respectively. The mechanism by which StAR mediates cholesterol transfer in the mitochondria has not been fully characterized. However, the tertiary structure of the START domain of a StAR homolog has been solved, and identification of a cholesterol-binding hydrophobic tunnel within this domain raises the possibility that StAR acts as a cholesterol-shuttling protein." @default.
- W2147322409 created "2016-06-24" @default.
- W2147322409 creator A5032054949 @default.
- W2147322409 date "2001-03-01" @default.
- W2147322409 modified "2023-10-18" @default.
- W2147322409 title "StAR Protein and the Regulation of Steroid Hormone Biosynthesis" @default.
- W2147322409 cites W145641687 @default.
- W2147322409 cites W1479988478 @default.
- W2147322409 cites W1480527955 @default.
- W2147322409 cites W1512269360 @default.
- W2147322409 cites W15176748 @default.
- W2147322409 cites W1518437590 @default.
- W2147322409 cites W1537167627 @default.
- W2147322409 cites W1578908619 @default.
- W2147322409 cites W1610204701 @default.
- W2147322409 cites W1636822060 @default.
- W2147322409 cites W1651094673 @default.
- W2147322409 cites W1660177314 @default.
- W2147322409 cites W179357761 @default.
- W2147322409 cites W182877500 @default.
- W2147322409 cites W1963805664 @default.
- W2147322409 cites W1964037813 @default.
- W2147322409 cites W1964899257 @default.
- W2147322409 cites W1965727701 @default.
- W2147322409 cites W1966080912 @default.
- W2147322409 cites W1966090719 @default.
- W2147322409 cites W1967838762 @default.
- W2147322409 cites W1968624316 @default.
- W2147322409 cites W1971590500 @default.
- W2147322409 cites W1974635112 @default.
- W2147322409 cites W1975363999 @default.
- W2147322409 cites W1976472536 @default.
- W2147322409 cites W1977505173 @default.
- W2147322409 cites W1979318851 @default.
- W2147322409 cites W1980419069 @default.
- W2147322409 cites W1980602751 @default.
- W2147322409 cites W1981405811 @default.
- W2147322409 cites W1984396356 @default.
- W2147322409 cites W1985257301 @default.
- W2147322409 cites W1987658122 @default.
- W2147322409 cites W1988170155 @default.
- W2147322409 cites W1990095295 @default.
- W2147322409 cites W1991711276 @default.
- W2147322409 cites W1999522505 @default.
- W2147322409 cites W2003129236 @default.
- W2147322409 cites W2003590725 @default.
- W2147322409 cites W2004031738 @default.
- W2147322409 cites W2005235866 @default.
- W2147322409 cites W2009443375 @default.
- W2147322409 cites W2010597703 @default.
- W2147322409 cites W2012311114 @default.
- W2147322409 cites W2015339229 @default.
- W2147322409 cites W2019771407 @default.
- W2147322409 cites W2021326860 @default.
- W2147322409 cites W2021994993 @default.
- W2147322409 cites W2023771004 @default.
- W2147322409 cites W2024500009 @default.
- W2147322409 cites W2027002237 @default.
- W2147322409 cites W2027032504 @default.
- W2147322409 cites W2027128457 @default.
- W2147322409 cites W2027996712 @default.
- W2147322409 cites W2029828300 @default.
- W2147322409 cites W2031091378 @default.
- W2147322409 cites W2033271492 @default.
- W2147322409 cites W2035325415 @default.
- W2147322409 cites W2036495761 @default.
- W2147322409 cites W2036638367 @default.
- W2147322409 cites W2038061749 @default.
- W2147322409 cites W2038220184 @default.
- W2147322409 cites W2039490460 @default.
- W2147322409 cites W2040544725 @default.
- W2147322409 cites W2041645257 @default.
- W2147322409 cites W2042051730 @default.
- W2147322409 cites W2042820631 @default.
- W2147322409 cites W2044204798 @default.
- W2147322409 cites W2050555395 @default.
- W2147322409 cites W2051843585 @default.
- W2147322409 cites W2051890768 @default.
- W2147322409 cites W2053497150 @default.
- W2147322409 cites W2055675927 @default.
- W2147322409 cites W2056353546 @default.
- W2147322409 cites W2057529735 @default.
- W2147322409 cites W2059619149 @default.
- W2147322409 cites W2061819574 @default.
- W2147322409 cites W2061933315 @default.
- W2147322409 cites W2066217148 @default.
- W2147322409 cites W2069513152 @default.
- W2147322409 cites W2071028118 @default.
- W2147322409 cites W2071047616 @default.
- W2147322409 cites W2074427038 @default.
- W2147322409 cites W2075184035 @default.
- W2147322409 cites W2075855675 @default.
- W2147322409 cites W2079687705 @default.
- W2147322409 cites W2080044263 @default.
- W2147322409 cites W2081249104 @default.
- W2147322409 cites W2081500836 @default.
- W2147322409 cites W2083447043 @default.
- W2147322409 cites W2083532749 @default.