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• W2147331657 abstract "Dr. Brunella Guerra et al. need to be congratulated for the completion of their observational study [ [1] Guerra B. Ghi T. Quarta S. et al. Pregnancy outcome after early detection of bacterial vaginosis. Eur J Obstet Gynecol Reprod Biol. 2006; 128: 40-45 Abstract Full Text Full Text PDF PubMed Scopus (48) Google Scholar ]. They confirmed that early screening for bacterial vaginosis in pregnant women who experienced a preterm delivery may help in predicting the risk of adverse outcome. A few years ago, Gerber et al. showed that microbial invasion of the amniotic cavity in the early second trimester of pregnancy can identify most women at risk for subsequent preterm labor and delivery [ [2] Gerber S. Vial Y. Hohlfeld P. Witkin S.S. Detection of ureaplasma urealyticum in second-trimester amniotic fluid by polymerase chain reaction correlates with subsequent preterm labor and delivery. J Infect Dis. 2003; 187: 518-521 Crossref PubMed Scopus (200) Google Scholar ]. Together, these studies and others suggest that the inflammatory/infectious process associated with prematurity probably develops over a several weeks, starting during the first trimester and early second trimester. These data explain in part why antibiotic treatment during the second trimester of pregnancy fails to prevent the majority of preterm births in randomized controlled trials (RCTs). Response to comment on “Pregnancy outcome after early detection of bacterial vaginosis” [Eur. J. Obstet. Gynecol. Reprod. Biol. 128 (2006) 40–45]European Journal of Obstetrics and Gynecology and Reproductive BiologyVol. 132Issue 1PreviewWe really appreciate the interest shown by Dr. Morency and Dr. Bujold in commenting on our paper. As suggested by our study and further highlighted by the above-mentioned authors, the crucial time for understanding or affecting the natural history of premature labour is very early pregnancy. After the 1st trimester the inflammation pathway arising from lower genital tract infection and possibly leading to premature labour or miscarriage is on its way and it is extremely difficult to counteract. Irrespective of past experiences, we should therefore focus on the early pregnancy group to be able to detect those who are at significantly higher risk of adverse pregnancy outcome. Full-Text PDF" @default.
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• W2147331657 title "Comment on “Pregnancy outcome after early detection of bacterial vaginosis” [Eur. J. Obstet. Gynecol. Reprod. Biol. 128 (2006) 40–45]" @default.
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• W2147331657 doi "https://doi.org/10.1016/j.ejogrb.2006.11.019" @default.
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