FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147339968> ?p ?o ?g. }

• W2147339968 endingPage "642" @default.
• W2147339968 startingPage "632" @default.
• W2147339968 abstract "The influence of 2-methoxyestradiol (2ME) was investigated on cell growth, morphology and spindle formation in a tumorigenic (MCF-7) and non-tumorigenic (MCF-12A) epithelial breast cell line. Inhibition of cell growth was more pronounced in the MCF-7 cells compared to the MCF-12A cells following 2ME treatment. Dose-dependent studies (10(-5)-10(-9) M) revealed that 10(-6) M 2ME inhibited cell growth by 44% in MCF-12A cells and by 84% in MCF-7 cells (p-value < 0.05). 2ME-treated MCF-7 cells showed abnormal metaphase cells, membrane blebbing, apoptotic cells and disrupted spindle formation. These observations were either absent or less prominent in MCF-12A cells. 2ME had no effect on the length of the cell cycle between S-phase and the time a mitotic peak was reached in either cell line but MCF-7 cells were blocked in mitosis with no statistically significant alterations in the phosphorylation status of Cdc25C. Nevertheless, Cdc2 activity was significantly increased in MCF-7 cells compared to MCF-12A cells (p-value < 0.05). The results indicate that 2ME disrupts mitotic spindle formation and enhances Cdc2 kinase activity, leading to persistence of the spindle checkpoint and thus prolonged metaphase arrest that may result in the induction of apoptosis. The tumorigenic MCF-7 cells were especially sensitive to 2ME treatment compared to the normal MCF-12A cells. Therefore, differential mechanism(s) of growth inhibition are evident between the normal and tumorigenic cells." @default.
• W2147339968 created "2016-06-24" @default.
• W2147339968 creator A5032988630 @default.
• W2147339968 creator A5037555113 @default.
• W2147339968 creator A5045288794 @default.
• W2147339968 creator A5058448027 @default.
• W2147339968 date "2008-07-01" @default.
• W2147339968 modified "2023-10-17" @default.
• W2147339968 title "<i>In vitro</i>effects of 2‐methoxyestradiol on MCF‐12A and MCF‐7 cell growth, morphology and mitotic spindle formation" @default.
• W2147339968 cites W1969875009 @default.
• W2147339968 cites W1970825176 @default.
• W2147339968 cites W1975949315 @default.
• W2147339968 cites W1983964043 @default.
• W2147339968 cites W1984119235 @default.
• W2147339968 cites W1997788361 @default.
• W2147339968 cites W1998948981 @default.
• W2147339968 cites W2001787486 @default.
• W2147339968 cites W2007896773 @default.
• W2147339968 cites W2013142209 @default.
• W2147339968 cites W2015404852 @default.
• W2147339968 cites W2016473260 @default.
• W2147339968 cites W2021797949 @default.
• W2147339968 cites W2030736038 @default.
• W2147339968 cites W2034426069 @default.
• W2147339968 cites W2038809726 @default.
• W2147339968 cites W2039289003 @default.
• W2147339968 cites W2042215748 @default.
• W2147339968 cites W2047817078 @default.
• W2147339968 cites W2052162735 @default.
• W2147339968 cites W2072720547 @default.
• W2147339968 cites W2088370046 @default.
• W2147339968 cites W2098535272 @default.
• W2147339968 cites W2101173071 @default.
• W2147339968 cites W2107932490 @default.
• W2147339968 cites W2108499288 @default.
• W2147339968 cites W2119619939 @default.
• W2147339968 cites W2123820544 @default.
• W2147339968 cites W2139149338 @default.
• W2147339968 cites W2150836292 @default.
• W2147339968 cites W2154559260 @default.
• W2147339968 cites W2158054014 @default.
• W2147339968 cites W2169385461 @default.
• W2147339968 cites W2171386133 @default.
• W2147339968 cites W2313934125 @default.
• W2147339968 cites W2330248224 @default.
• W2147339968 cites W2332678957 @default.
• W2147339968 cites W2404021914 @default.
• W2147339968 cites W322972368 @default.
• W2147339968 cites W4293247451 @default.
• W2147339968 doi "https://doi.org/10.1002/cbf.1489" @default.
• W2147339968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18508385" @default.
• W2147339968 hasPublicationYear "2008" @default.
• W2147339968 type Work @default.
• W2147339968 sameAs 2147339968 @default.
• W2147339968 citedByCount "38" @default.
• W2147339968 countsByYear W21473399682012 @default.
• W2147339968 countsByYear W21473399682013 @default.
• W2147339968 countsByYear W21473399682014 @default.
• W2147339968 countsByYear W21473399682015 @default.
• W2147339968 countsByYear W21473399682017 @default.
• W2147339968 countsByYear W21473399682018 @default.
• W2147339968 countsByYear W21473399682019 @default.
• W2147339968 countsByYear W21473399682020 @default.
• W2147339968 countsByYear W21473399682021 @default.
• W2147339968 countsByYear W21473399682022 @default.
• W2147339968 crossrefType "journal-article" @default.
• W2147339968 hasAuthorship W2147339968A5032988630 @default.
• W2147339968 hasAuthorship W2147339968A5037555113 @default.
• W2147339968 hasAuthorship W2147339968A5045288794 @default.
• W2147339968 hasAuthorship W2147339968A5058448027 @default.
• W2147339968 hasBestOaLocation W21473399682 @default.
• W2147339968 hasConcept C104317684 @default.
• W2147339968 hasConcept C105696609 @default.
• W2147339968 hasConcept C109541995 @default.
• W2147339968 hasConcept C121608353 @default.
• W2147339968 hasConcept C1491633281 @default.
• W2147339968 hasConcept C190283241 @default.
• W2147339968 hasConcept C29537977 @default.
• W2147339968 hasConcept C2994423619 @default.
• W2147339968 hasConcept C30481170 @default.
• W2147339968 hasConcept C3453395 @default.
• W2147339968 hasConcept C47432576 @default.
• W2147339968 hasConcept C502942594 @default.
• W2147339968 hasConcept C54355233 @default.
• W2147339968 hasConcept C55493867 @default.
• W2147339968 hasConcept C62112901 @default.
• W2147339968 hasConcept C70278784 @default.
• W2147339968 hasConcept C81885089 @default.
• W2147339968 hasConcept C85813293 @default.
• W2147339968 hasConcept C86803240 @default.
• W2147339968 hasConcept C93304396 @default.
• W2147339968 hasConcept C95444343 @default.
• W2147339968 hasConcept C96232424 @default.
• W2147339968 hasConceptScore W2147339968C104317684 @default.
• W2147339968 hasConceptScore W2147339968C105696609 @default.
• W2147339968 hasConceptScore W2147339968C109541995 @default.
• W2147339968 hasConceptScore W2147339968C121608353 @default.
• W2147339968 hasConceptScore W2147339968C1491633281 @default.

• next