FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147341925> ?p ?o ?g. }

• W2147341925 endingPage "234" @default.
• W2147341925 startingPage "230" @default.
• W2147341925 abstract "The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging to isoflavones are similar in the chemical structures, the inhibitory potencies for CYP1A2 were distinguished markedly between these two flavonoids. In computer-docking simulation, apigenin interacted with the same mode of cocrystallized α-naphthoflavone in the active site of CYP1A2, and then the B ring of apigenin was placed close to the heme iron of the enzyme with a single orientation. In contrast, the docked genistein conformation showed two different binding modes, and the A ring of genistein was oriented to the heme iron of CYP1A2. Furthermore, the binding free energy of apigenin was lower than that of genistein. These results demonstrate a possible mechanism that causes the differential inhibitory potencies of apigenin and genistein for CYP1A2. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:230–234, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20328" @default.
• W2147341925 created "2016-06-24" @default.
• W2147341925 creator A5007159644 @default.
• W2147341925 creator A5009161470 @default.
• W2147341925 creator A5022048163 @default.
• W2147341925 creator A5040189091 @default.
• W2147341925 creator A5043590671 @default.
• W2147341925 creator A5061634245 @default.
• W2147341925 creator A5086435132 @default.
• W2147341925 date "2010-07-01" @default.
• W2147341925 modified "2023-10-16" @default.
• W2147341925 title "Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein" @default.
• W2147341925 cites W1650427240 @default.
• W2147341925 cites W1968819739 @default.
• W2147341925 cites W1980998456 @default.
• W2147341925 cites W2001876358 @default.
• W2147341925 cites W2021232512 @default.
• W2147341925 cites W2031356430 @default.
• W2147341925 cites W2036201691 @default.
• W2147341925 cites W2042217104 @default.
• W2147341925 cites W2047254368 @default.
• W2147341925 cites W2053884244 @default.
• W2147341925 cites W2053941321 @default.
• W2147341925 cites W2071936413 @default.
• W2147341925 cites W2073655787 @default.
• W2147341925 cites W2088342692 @default.
• W2147341925 cites W2091275993 @default.
• W2147341925 cites W2092959529 @default.
• W2147341925 cites W2132629607 @default.
• W2147341925 cites W2158534713 @default.
• W2147341925 doi "https://doi.org/10.1002/jbt.20328" @default.
• W2147341925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20806393" @default.
• W2147341925 hasPublicationYear "2010" @default.
• W2147341925 type Work @default.
• W2147341925 sameAs 2147341925 @default.
• W2147341925 citedByCount "13" @default.
• W2147341925 countsByYear W21473419252012 @default.
• W2147341925 countsByYear W21473419252013 @default.
• W2147341925 countsByYear W21473419252015 @default.
• W2147341925 countsByYear W21473419252016 @default.
• W2147341925 countsByYear W21473419252017 @default.
• W2147341925 countsByYear W21473419252018 @default.
• W2147341925 countsByYear W21473419252019 @default.
• W2147341925 countsByYear W21473419252020 @default.
• W2147341925 countsByYear W21473419252021 @default.
• W2147341925 countsByYear W21473419252022 @default.
• W2147341925 crossrefType "journal-article" @default.
• W2147341925 hasAuthorship W2147341925A5007159644 @default.
• W2147341925 hasAuthorship W2147341925A5009161470 @default.
• W2147341925 hasAuthorship W2147341925A5022048163 @default.
• W2147341925 hasAuthorship W2147341925A5040189091 @default.
• W2147341925 hasAuthorship W2147341925A5043590671 @default.
• W2147341925 hasAuthorship W2147341925A5061634245 @default.
• W2147341925 hasAuthorship W2147341925A5086435132 @default.
• W2147341925 hasBestOaLocation W21473419252 @default.
• W2147341925 hasConcept C134018914 @default.
• W2147341925 hasConcept C181199279 @default.
• W2147341925 hasConcept C185592680 @default.
• W2147341925 hasConcept C2776292868 @default.
• W2147341925 hasConcept C2777302768 @default.
• W2147341925 hasConcept C2777810353 @default.
• W2147341925 hasConcept C2778004101 @default.
• W2147341925 hasConcept C2778298627 @default.
• W2147341925 hasConcept C2778609962 @default.
• W2147341925 hasConcept C2779054382 @default.
• W2147341925 hasConcept C2779478871 @default.
• W2147341925 hasConcept C43617362 @default.
• W2147341925 hasConcept C526171541 @default.
• W2147341925 hasConcept C55493867 @default.
• W2147341925 hasConcept C71240020 @default.
• W2147341925 hasConcept C86745063 @default.
• W2147341925 hasConcept C86803240 @default.
• W2147341925 hasConceptScore W2147341925C134018914 @default.
• W2147341925 hasConceptScore W2147341925C181199279 @default.
• W2147341925 hasConceptScore W2147341925C185592680 @default.
• W2147341925 hasConceptScore W2147341925C2776292868 @default.
• W2147341925 hasConceptScore W2147341925C2777302768 @default.
• W2147341925 hasConceptScore W2147341925C2777810353 @default.
• W2147341925 hasConceptScore W2147341925C2778004101 @default.
• W2147341925 hasConceptScore W2147341925C2778298627 @default.
• W2147341925 hasConceptScore W2147341925C2778609962 @default.
• W2147341925 hasConceptScore W2147341925C2779054382 @default.
• W2147341925 hasConceptScore W2147341925C2779478871 @default.
• W2147341925 hasConceptScore W2147341925C43617362 @default.
• W2147341925 hasConceptScore W2147341925C526171541 @default.
• W2147341925 hasConceptScore W2147341925C55493867 @default.
• W2147341925 hasConceptScore W2147341925C71240020 @default.
• W2147341925 hasConceptScore W2147341925C86745063 @default.
• W2147341925 hasConceptScore W2147341925C86803240 @default.
• W2147341925 hasIssue "4" @default.
• W2147341925 hasLocation W21473419251 @default.
• W2147341925 hasLocation W21473419252 @default.
• W2147341925 hasLocation W21473419253 @default.
• W2147341925 hasLocation W21473419254 @default.
• W2147341925 hasOpenAccess W2147341925 @default.
• W2147341925 hasPrimaryLocation W21473419251 @default.
• W2147341925 hasRelatedWork W1982675389 @default.
• W2147341925 hasRelatedWork W1990979855 @default.

• next