FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147345799> ?p ?o ?g. }

• W2147345799 abstract "About 15 years ago it was proposed that generation of the truncated protein p25 contributes to toxicity in Alzheimer's disease (AD). p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5). The biochemical properties of p25 suggested that its generation would cause Cdk5 overactivation and tau hyperphosphorylation, a prerequisite for neurofibrillary tangle (NFT) formation. Whilst this model was appealing as it explained NFT formation, many laboratories could not confirm the finding of increased p25 generation in brain from AD patients. On the contrary, it emerged that p25 levels are reduced in AD. This reduction occurs primarily in the early stages of the disease. Further, p25 generation in the mouse hippocampus is associated with normal memory formation and p25 overexpression enhances synaptogenesis. Therefore, it transpires that p25 generation is a molecular memory mechanism that is impaired in early AD. I discuss the prospect that investigation of p25-regulated proteins will shed light into mechanisms underlying synaptic degeneration associated with memory decline in AD." @default.
• W2147345799 created "2016-06-24" @default.
• W2147345799 creator A5085793083 @default.
• W2147345799 date "2014-05-01" @default.
• W2147345799 modified "2023-09-26" @default.
• W2147345799 title "Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease" @default.
• W2147345799 cites W1496279155 @default.
• W2147345799 cites W1563116834 @default.
• W2147345799 cites W1577837690 @default.
• W2147345799 cites W1969651353 @default.
• W2147345799 cites W1972551552 @default.
• W2147345799 cites W1979014608 @default.
• W2147345799 cites W1979833059 @default.
• W2147345799 cites W1989540421 @default.
• W2147345799 cites W1989971341 @default.
• W2147345799 cites W1992491411 @default.
• W2147345799 cites W2000685126 @default.
• W2147345799 cites W2010199350 @default.
• W2147345799 cites W2016231557 @default.
• W2147345799 cites W2020460747 @default.
• W2147345799 cites W2039568351 @default.
• W2147345799 cites W2042573135 @default.
• W2147345799 cites W2082905363 @default.
• W2147345799 cites W2089141103 @default.
• W2147345799 cites W2091857357 @default.
• W2147345799 cites W2092765133 @default.
• W2147345799 cites W2102087601 @default.
• W2147345799 cites W2117333689 @default.
• W2147345799 cites W2131180711 @default.
• W2147345799 cites W2147435466 @default.
• W2147345799 cites W2159663149 @default.
• W2147345799 cites W2162583663 @default.
• W2147345799 cites W2168334242 @default.
• W2147345799 cites W2169035195 @default.
• W2147345799 cites W2169135478 @default.
• W2147345799 doi "https://doi.org/10.3389/fnmol.2014.00036" @default.
• W2147345799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4013459" @default.
• W2147345799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24822036" @default.
• W2147345799 hasPublicationYear "2014" @default.
• W2147345799 type Work @default.
• W2147345799 sameAs 2147345799 @default.
• W2147345799 citedByCount "20" @default.
• W2147345799 countsByYear W21473457992015 @default.
• W2147345799 countsByYear W21473457992016 @default.
• W2147345799 countsByYear W21473457992017 @default.
• W2147345799 countsByYear W21473457992018 @default.
• W2147345799 countsByYear W21473457992020 @default.
• W2147345799 countsByYear W21473457992021 @default.
• W2147345799 countsByYear W21473457992022 @default.
• W2147345799 countsByYear W21473457992023 @default.
• W2147345799 crossrefType "journal-article" @default.
• W2147345799 hasAuthorship W2147345799A5085793083 @default.
• W2147345799 hasBestOaLocation W21473457991 @default.
• W2147345799 hasConcept C121332964 @default.
• W2147345799 hasConcept C121738310 @default.
• W2147345799 hasConcept C142724271 @default.
• W2147345799 hasConcept C15744967 @default.
• W2147345799 hasConcept C169760540 @default.
• W2147345799 hasConcept C177738377 @default.
• W2147345799 hasConcept C184235292 @default.
• W2147345799 hasConcept C202444582 @default.
• W2147345799 hasConcept C2778198054 @default.
• W2147345799 hasConcept C2778670691 @default.
• W2147345799 hasConcept C2779134260 @default.
• W2147345799 hasConcept C2779721402 @default.
• W2147345799 hasConcept C2781161787 @default.
• W2147345799 hasConcept C33923547 @default.
• W2147345799 hasConcept C502032728 @default.
• W2147345799 hasConcept C62520636 @default.
• W2147345799 hasConcept C65232495 @default.
• W2147345799 hasConcept C68026918 @default.
• W2147345799 hasConcept C71924100 @default.
• W2147345799 hasConcept C82495950 @default.
• W2147345799 hasConcept C86803240 @default.
• W2147345799 hasConcept C89611455 @default.
• W2147345799 hasConcept C95444343 @default.
• W2147345799 hasConcept C97029542 @default.
• W2147345799 hasConceptScore W2147345799C121332964 @default.
• W2147345799 hasConceptScore W2147345799C121738310 @default.
• W2147345799 hasConceptScore W2147345799C142724271 @default.
• W2147345799 hasConceptScore W2147345799C15744967 @default.
• W2147345799 hasConceptScore W2147345799C169760540 @default.
• W2147345799 hasConceptScore W2147345799C177738377 @default.
• W2147345799 hasConceptScore W2147345799C184235292 @default.
• W2147345799 hasConceptScore W2147345799C202444582 @default.
• W2147345799 hasConceptScore W2147345799C2778198054 @default.
• W2147345799 hasConceptScore W2147345799C2778670691 @default.
• W2147345799 hasConceptScore W2147345799C2779134260 @default.
• W2147345799 hasConceptScore W2147345799C2779721402 @default.
• W2147345799 hasConceptScore W2147345799C2781161787 @default.
• W2147345799 hasConceptScore W2147345799C33923547 @default.
• W2147345799 hasConceptScore W2147345799C502032728 @default.
• W2147345799 hasConceptScore W2147345799C62520636 @default.
• W2147345799 hasConceptScore W2147345799C65232495 @default.
• W2147345799 hasConceptScore W2147345799C68026918 @default.
• W2147345799 hasConceptScore W2147345799C71924100 @default.
• W2147345799 hasConceptScore W2147345799C82495950 @default.
• W2147345799 hasConceptScore W2147345799C86803240 @default.
• W2147345799 hasConceptScore W2147345799C89611455 @default.
• W2147345799 hasConceptScore W2147345799C95444343 @default.

• next