FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147347457> ?p ?o ?g. }

• W2147347457 endingPage "1135" @default.
• W2147347457 startingPage "1128" @default.
• W2147347457 abstract "Background & Aims: To examine the involvement of EP3 receptors in physiological regulation of duodenal HCO3− secretion, we disrupted the gene encoding EP receptors in mice by homologous recombination and evaluated acid-induced HCO3− secretion, which is physiologically important in the mucosal defense against acid injury, using EP1- and EP3-receptor knockout mice. Methods: The experiments were performed in the following 3 groups of mice after 18 hours of fasting: wild-type [WT (+/+)] mice, EP1-receptor knockout [EP1 (−/−)] mice, and EP3-receptor knockout [EP3 (−/−)] mice. Under urethane anesthesia, the proximal duodenal loop was perfused with saline that was gassed with 100% O2, heated at 37°C, and kept in a reservoir, and HCO3− secretion was measured at pH 7.0 using a pH-stat method and by adding 5 mmol/L HCl. Results: The duodenum of WT (+/+) mice increased HCO3− secretion in response to luminal perfusion of prostaglandin E2 and forskolin as well as mucosal acidification. The latter effect was significantly inhibited by prior administration of indomethacin. HCO3− response to acid was observed in EP1 (−/−) mice but disappeared totally in EP3 (−/−) animals, although the acidification increased mucosal PGE2 generation by similar degrees in all groups. The HCO3− stimulatory action of PGE2 was also absent in EP3 (−/−) but not EP1 (−/−) mice, but forskolin effect was observed in both groups of animals, similar to WT (+/+) mice. Perfusion of the duodenum with 20 mmol/L HCl for 4 hours caused severe damage in EP3 (−/−) mice and WT (+/+) animals pretreated with indomethacin, but not in EP1 (−/−) mice. Conclusions: The presence of EP3-receptors is essential for maintaining duodenal HCO3− secretion and mucosal integrity against luminal acid.GASTROENTEROLOGY 1999;117:1128-1135" @default.
• W2147347457 created "2016-06-24" @default.
• W2147347457 creator A5016507067 @default.
• W2147347457 creator A5024624058 @default.
• W2147347457 creator A5036661698 @default.
• W2147347457 creator A5044168175 @default.
• W2147347457 creator A5044801477 @default.
• W2147347457 creator A5046173978 @default.
• W2147347457 creator A5053545534 @default.
• W2147347457 creator A5058119453 @default.
• W2147347457 creator A5090713682 @default.
• W2147347457 date "1999-11-01" @default.
• W2147347457 modified "2023-10-03" @default.
• W2147347457 title "Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E–receptor subtype EP3" @default.
• W2147347457 cites W1460228636 @default.
• W2147347457 cites W1575388506 @default.
• W2147347457 cites W1607540395 @default.
• W2147347457 cites W1647648618 @default.
• W2147347457 cites W1652980032 @default.
• W2147347457 cites W1780148870 @default.
• W2147347457 cites W1856590789 @default.
• W2147347457 cites W1913770988 @default.
• W2147347457 cites W1970523811 @default.
• W2147347457 cites W1971434151 @default.
• W2147347457 cites W2009342363 @default.
• W2147347457 cites W2034679499 @default.
• W2147347457 cites W2038976766 @default.
• W2147347457 cites W2053226669 @default.
• W2147347457 cites W2056635601 @default.
• W2147347457 cites W2069665342 @default.
• W2147347457 cites W2075063025 @default.
• W2147347457 cites W2081688069 @default.
• W2147347457 cites W2087405164 @default.
• W2147347457 cites W2142980049 @default.
• W2147347457 cites W2323425329 @default.
• W2147347457 cites W2473547252 @default.
• W2147347457 doi "https://doi.org/10.1016/s0016-5085(99)70398-7" @default.
• W2147347457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10535876" @default.
• W2147347457 hasPublicationYear "1999" @default.
• W2147347457 type Work @default.
• W2147347457 sameAs 2147347457 @default.
• W2147347457 citedByCount "107" @default.
• W2147347457 countsByYear W21473474572012 @default.
• W2147347457 countsByYear W21473474572013 @default.
• W2147347457 countsByYear W21473474572014 @default.
• W2147347457 countsByYear W21473474572015 @default.
• W2147347457 countsByYear W21473474572016 @default.
• W2147347457 countsByYear W21473474572017 @default.
• W2147347457 countsByYear W21473474572019 @default.
• W2147347457 countsByYear W21473474572021 @default.
• W2147347457 crossrefType "journal-article" @default.
• W2147347457 hasAuthorship W2147347457A5016507067 @default.
• W2147347457 hasAuthorship W2147347457A5024624058 @default.
• W2147347457 hasAuthorship W2147347457A5036661698 @default.
• W2147347457 hasAuthorship W2147347457A5044168175 @default.
• W2147347457 hasAuthorship W2147347457A5044801477 @default.
• W2147347457 hasAuthorship W2147347457A5046173978 @default.
• W2147347457 hasAuthorship W2147347457A5053545534 @default.
• W2147347457 hasAuthorship W2147347457A5058119453 @default.
• W2147347457 hasAuthorship W2147347457A5090713682 @default.
• W2147347457 hasBestOaLocation W21473474571 @default.
• W2147347457 hasConcept C126322002 @default.
• W2147347457 hasConcept C134018914 @default.
• W2147347457 hasConcept C146957229 @default.
• W2147347457 hasConcept C170493617 @default.
• W2147347457 hasConcept C178592051 @default.
• W2147347457 hasConcept C182704531 @default.
• W2147347457 hasConcept C185592680 @default.
• W2147347457 hasConcept C2776809568 @default.
• W2147347457 hasConcept C2777198256 @default.
• W2147347457 hasConcept C2777956040 @default.
• W2147347457 hasConcept C2778938600 @default.
• W2147347457 hasConcept C2779276759 @default.
• W2147347457 hasConcept C2780664492 @default.
• W2147347457 hasConcept C2781112554 @default.
• W2147347457 hasConcept C49039625 @default.
• W2147347457 hasConcept C71924100 @default.
• W2147347457 hasConcept C86803240 @default.
• W2147347457 hasConceptScore W2147347457C126322002 @default.
• W2147347457 hasConceptScore W2147347457C134018914 @default.
• W2147347457 hasConceptScore W2147347457C146957229 @default.
• W2147347457 hasConceptScore W2147347457C170493617 @default.
• W2147347457 hasConceptScore W2147347457C178592051 @default.
• W2147347457 hasConceptScore W2147347457C182704531 @default.
• W2147347457 hasConceptScore W2147347457C185592680 @default.
• W2147347457 hasConceptScore W2147347457C2776809568 @default.
• W2147347457 hasConceptScore W2147347457C2777198256 @default.
• W2147347457 hasConceptScore W2147347457C2777956040 @default.
• W2147347457 hasConceptScore W2147347457C2778938600 @default.
• W2147347457 hasConceptScore W2147347457C2779276759 @default.
• W2147347457 hasConceptScore W2147347457C2780664492 @default.
• W2147347457 hasConceptScore W2147347457C2781112554 @default.
• W2147347457 hasConceptScore W2147347457C49039625 @default.
• W2147347457 hasConceptScore W2147347457C71924100 @default.
• W2147347457 hasConceptScore W2147347457C86803240 @default.
• W2147347457 hasIssue "5" @default.
• W2147347457 hasLocation W21473474571 @default.
• W2147347457 hasLocation W21473474572 @default.

• next